Phytotherapy for Polycystic Ovarian Syndrome: A review of the literature and evaluation of practitioners’ experiences

Rooney, Sara; Pendry, Barbara

doi:10.1016/j.hermed.2014.05.001

Cited by 13 publications

(7 citation statements)

References 66 publications

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“…Polycystic ovarian syndrome (PCOS) is a prevalent endocrine condition with important endocrine, cardiovascular, and metabolic consequences (Rooney & Pendry, ). Hyperinsulinemia and insulin resistance have a key role in the pathogenesis of PCOS that is characterized by ovulatory dysfunction, hyperandrogenism, and presence of polycystic ovaries (Li et al, ).…”

Section: Endocrinementioning

confidence: 99%

Berberine and barberry (Berberis vulgaris): A clinical review

Imenshahidi

Hosseinzadeh

2019

Phytotherapy Research

255

134

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Barberry (Berberis vulgaris L.) has different medicinal applications in folk medicine of Iran. Berberine, an alkaloid constituent of this plant, is present in the roots, rhizomes, stem, and bark of B. vulgaris and many other plants. There have been many clinical trials conducted that suggested a wide range of therapeutic applications. Here, we investigated the clinical uses of berberine and B. vulgaris in the treatment of different diseases in humans. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences and Science Direct) was used to identify the clinical trials on B. vulgaris and berberine. Lipid‐lowering and insulin‐resistance improving actions are the most studied properties of berberine in numerous randomized clinical trials. There are also clinical trials regarding cardiovascular, anticancer, gastrointestinal, CNS, endocrine, and so on. Berberine has very low toxicity in usual doses and reveals clinical benefits without major side effects. Only mild gastrointestinal reactions may occur in some patients. The purpose of this review is to provide a summary concerning the clinical trials conducted on berberine to improve the clinical application of this nutraceutical in different diseases. In this review article, we used 77 clinical studies on human subjects.

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Section: Endocrinementioning

confidence: 99%

Berberine and barberry (Berberis vulgaris): A clinical review

Imenshahidi

Hosseinzadeh

2019

Phytotherapy Research

255

134

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“…Participants were included if they 1 were women aged 18–44, 2 presented with oligomenorrhoea or amenorrhoea and 3 received a diagnosis of PCOS consistent with Rotterdam criteria. 28 Women were excluded if they 1 presented with other causes of hyperandrogenism or menstrual irregularities, 2 were currently or suspected to be pregnant, or actively trying to conceive, 3 had been breast feeding in the past 6 months, 4 were receiving prohibited treatments such as hormonal contraceptives, 5 had a history of liver or kidney pathologies, 6 had a history of psychotic illness or eating disorders, 7 had currently active major depression, 8 were at risk of harmful and hazardous drinking, 9 reported known allergies to herbal ingredients within standardised CHM, 10 did not possess spoken or written language skills necessary to participate, 11 were unable to attend proposed study visits, 12 presented with abnormal liver and/or kidney function at screening. Diagnosis of PCOS was confirmed through participants providing medical letters and reports from previous medical investigations.…”

Section: Methodsmentioning

confidence: 99%

“…Complementary medicines such as multiherb Chinese herbal medicines (CHMs) are reportedly used by over 70% of women with PCOS and is a commonly encountered condition among herbal practitioners. 11 12 Previous studies have demonstrated the potential for certain herbs for PCOS through mechanisms such as increasing granulosa production of oestradiol and progesterone, increasing aromatisation of testosterone to 17-β oestradiol and reducing levels of luteinising hormone. 13–15 There is also emerging evidence from randomised controlled trials (RCTs) conducted in China and a pilot study conducted recently in the USA highlights the potential for CHM in the management of symptoms such as oligomenorrhoea and amenorrhoea.…”

Section: Introductionmentioning

confidence: 99%

Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK

et al. 2017

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ObjectivesTo explore feasibility of a randomised study using standardised or individualised multiherb Chinese herbal medicine (CHM) for oligomenorrhoea and amenorrhoea in women with polycystic ovary syndrome (PCOS), to pilot study methods and to obtain clinical data to support sample size calculations.DesignProspective, pragmatic, randomised feasibility and pilot study with participant and practitioner blinding.Setting2 private herbal practices in the UK.Participants40 women diagnosed with PCOS and oligomenorrhoea or amenorrhoea following Rotterdam criteria.Intervention6 months of either standardised CHM or individualised CHM, 16 g daily taken orally as a tea.Main outcome measuresOur primary objective was to determine whether oligomenorrhoea and amenorrhoea were appropriate as the primary outcome measures for the main study. Estimates of treatment effects were obtained for menstrual rate, body mass index (BMI), weight and hirsutism. Data were collected regarding safety, feasibility and acceptability.ResultsOf the 40 participants recruited, 29 (72.5%) completed the study. The most frequently cited symptoms of concern were hirsutism, weight and menstrual irregularity. Statistically significant improvements in menstrual rates were found at 6 months within group for both standardised CHM (mean difference (MD) 0.18±0.06, 95% CI 0.06 to 0.29; p=0.0027) and individualised CHM (MD 0.27±0.06, 95% CI 0.15 to 0.39; p<0.001), though not between group (p=0.26). No improvements were observed for BMI nor for weight in either group. Improvements in hirsutism scores found within group for both groups were not statistically significant between group (p=0.09). Liver and kidney function and adverse events data were largely normal. Participant feedback suggests changing to tablet administration could facilitate adherence.ConclusionsA CHM randomised controlled trial for PCOS is feasible and preliminary data suggest that both individualised and standardised multiherb CHMs have similar safety profiles and clinical effects on promoting menstrual regularity. These data will inform the design of a study in primary care that will incorporate an appropriate control.Trial registration numberISRCTN 31072075; Results.

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“…One particular form of HM, herbal formula, involves the use of some herbs in a formula to improve a set of problems or a syndrome. Herbal formula and single herb were reportedly used by over 70% of women with PCOS and are a commonly encountered condition among traditional Chinese doctors [ 8 , 9 ]. Many studies showed that both herbal formula and single herb are helpful for fertility, menstrual health, and other aspects of PCOS.…”

Section: The Utilization Of Herbal Medicine In Women With Pcosmentioning

confidence: 99%

The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

Shen

Jin

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovary syndrome (PCOS) is a touchy clinical and public health problem worldwide, which adversely affects women’s health and health-related comorbidities for lifetime, and represents a tremendous burden for both the family of the patient and for society. According to the diagnostic criteria used and the population studied, the prevalence rate of PCOS is between 6% and 21%. However, current conventional modern medicines for PCOS are only moderately effective at controlling the signs and symptoms, while they are not thoroughly able to prevent complications. Therefore, many patients have turned to complementary and alternative medical (CAM) treatments. CAM use is wide spread among patients with PCOS, and more than 70% of patients use CAM at one point during their diseases. The patients’ primary motivations include dissatisfaction with available medications, perceive higher risk of drug side effects and crushing health burden and economic costs, desire for symptom relief, pursuit of shortening the course of disease, and the belief that CAM therapy is in accordance with the patients’ values and beliefs. At present, several CAM methods have been used in women with PCOS, which has achieved obvious effects. However, biologically plausible mechanisms of the action of traditional Chinese medicine- (TCM-) associated CAM for PCOS have not been systematically reviewed. This review briefly summarizes the current progress of the impact of herbal medicine on the outcomes of PCOS and introduces the mechanisms.

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Phytotherapy for Polycystic Ovarian Syndrome: A review of the literature and evaluation of practitioners’ experiences

Abstract: Abstract:Background: Polycystic Ovarian Syndrome (PCOS) is a common, complex,

Cited by 13 publications

References 66 publications

Berberine and barberry (Berberis vulgaris): A clinical review

Berberine and barberry (Berberis vulgaris): A clinical review

Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK

The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

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