Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Pagano, Ester; Laudato, Massimiliano; Griffo, Michele; Capasso, Raffaele

doi:10.1002/ptr.5084

Cited by 83 publications

(78 citation statements)

References 52 publications

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“…However, they may cause adverse effects such as loss or reduced libido, erectile dysfunction, orgasmic, ejaculatory dysfunction, development of high‐grade prostate cancers, potential negative cardiovascular events, and depression (Edwards, ). As a substitute, phytotherapeutics have been playing an important role in the treatment of BPH for over decades as they are well tolerated by most users and are not associated, contrarily to conventional medicine, with serious adverse events, including herb–drug interactions (Pagano et al , ).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice

Zou

Aboshora

et al. 2017

Phytother. Res.

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The inhibitory effect of maca extractant, lycopene, and their combination was evaluated in benign prostatic hyperplasia (BPH) mice induced by testosterone propionate. Mice were divided into a saline group, solvent control group and testosterone propionate-induced BPH mice [BPH model group, solvent BPH model group, benzyl glucosinolate group (1.44 mg/kg), maca group (60 mg/kg), lycopene treated (15, 5, and 2.5 mg/kg), maca (30 mg/kg) combine lycopene treated (7.5, 2.5, and 1.25 mg/kg), and finasteride treated]. Benzyl glucosinolate was used in order to evaluate its pharmacological activity on BPH to find out whether it is the major active component of maca aqueous extract. Finasteride was used as positive control. The compounds were administered once for 30 successive days. Compared with solvent BPH model group, BPH mice fed with maca (30 mg/kg) and lycopene (7.5 mg/kg) combination exhibited significant reductions in the prostatic index, prostatic acid phospatase, estradiol, testosterone, and dihydrotestosterone levels in serum. They also had similar histological compared with those aspects observed in the mice in the solvent control group. The results indicated that combination of maca and lycopene synergistically inhibits BPH in mice. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice

Zou

Aboshora

et al. 2017

Phytother. Res.

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“…An earlier study confirmed the potential role of β-sitosterol to manage BPH in human and animal models. Pagano et al [47] reported that β-sitosterol could improve urological symptoms and urine flow rate in BHP men. The relaxant effect of phytosterols from flaxseed, fruits of saw palmetto, and red clover on isolated prostate strips have been demonstrated [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips

Buncharoen

Saenphet

2019

JPRI

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Aims: To determine the relaxant activity of various extracts from the stems of Uraria rufa Blume and Caesalpinia sappan L. on rats’ prostate strips in vitro. Study Design: The relaxant efficacies of ethyl acetate and ethanolic extracts from the stems of U. rufa (UEA and UEOH) and C. sappan (CEA and CEOH) were tested on isolated rats’ prostate tissue pre-contracted by adrenaline. Place and Duration of Study: Department of Biology, Faculty of Science, Chiang Mai University, between February and September 2018. Methodology: A prostate strip was isolated, mounted in an organ bath filled with Krebs-Henseleit solution and induced to contract by adrenaline. The contracted strip was then exposed to each extract at 250 µg/mL for 30 minutes. The tension was recorded. Relaxant efficacies of various extracts were determined in prostate strips pre-contracted by adrenaline at 10 µM. All extracts were also determined for their bioactive components and the contents of total phenolics and total flavonoids. Results: The results showed that all of the extracts, as well as tamsulosin, a synthetic drug, exhibited relaxant effects (P < 0.001) on prostate smooth muscles. The UEA exhibited the most potency in relaxing the prostate smooth muscle with a maximal effect of 72.09 ± 2.15 %. The half-maximal effective concentration (EC50) values of the UEA, CEOH, UEOH and CEA were 140.23 ± 9.74, 226.35 ± 7.16, 235.35 ± 24.96 and 236.24 ± 5.05 µg/ml respectively, while tamsulosin was 86.83 ± 8.96 µg/ml. All extracts contained flavonoids, phenolics, sterols, tannins, phlobatannins, terpenoids, cardiac glycosides, alkaloids and reducing sugars. The highest contents of phenolics and flavonoids were found in CEOH and CEA respectively. Conclusion: We concluded that the ethyl acetate from the stems of U. rufa was the most potent in relaxing the prostate smooth muscles, and it may be useful to relieve the urological symptoms caused by benign prostatic hyperplasia (BPH).

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“…) (Ho et al , ; Rosner, 2012; Elamin and Montori, 2012; Varoni et al , 2014). For this reason, although traditional, narrative review articles on the efficacy and the safety of herbal medicine continue to be published (for example, Bella and Shamloul, ;Gulati, ; Pagano et al , ; Stohs, ; Stohs, ; Chingwaru et al , ; Gulati, ; Stohs and Hartman, ), systematic reviews increasingly are replacing them.…”

Section: The Clinical Efficacy Of Herbal Remediesmentioning

confidence: 99%

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

Izzo

Hoon-Kim

Radhakrishnan

et al. 2016

Phytotherapy Research

462

422

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Systematic reviews and meta-analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension, feverfew (Tanacetum partenium) for migraine prevention, ginger (Zingiber officinalis) for pregnancy-induced nausea, ginseng (Panax ginseng) for improving fasting glucose levels as well as phytoestrogens and St John's wort (Hypericum perforatum) for the relief of some symptoms in menopause. However, firm conclusions of efficacy cannot be generally drawn. On the other hand, inconclusive evidence of efficacy or contradictory results have been reported for Aloe vera in the treatment of psoriasis, cranberry (Vaccinium macrocarpon) in cystitis prevention, ginkgo (Ginkgo biloba) for tinnitus and intermittent claudication, echinacea (Echinacea spp.) for the prevention of common cold and pomegranate (Punica granatum) for the prevention/treatment of cardiovascular diseases. A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications. Nevertheless, potentially serious adverse events, including herb-drug interactions, have been described. This suggests the need to be vigilant when using herbal remedies, particularly in specific conditions, such as during pregnancy and in the paediatric population. Copyright © 2016 John Wiley & Sons, Ltd.

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Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Cited by 83 publications

References 52 publications

Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice

Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice

Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

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