2019
DOI: 10.1016/j.cbi.2019.108754
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Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy

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Cited by 75 publications
(66 citation statements)
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“…In the present study, significant upregulation of WBC counts implicated the immunopotentiation of C. nasus in response to salinity stress. Research studies of Nrf2 on mice and human beings indicated that Nrf2 also played a vital role in protection against inflammation [49][50][51]. Likewise, in this study, the C. nasus Nrf2-mediated antioxidant pathway was activated and further stimulated the upregulation of immune enzymes and molecules, indicating the regulatory role that Nrf2 plays in immunopotentiation in response to salinity stress (Figure 7).…”
Section: Antioxidant Regulation and Immunopotentiation Of C Nasus Nrsupporting
confidence: 60%
“…In the present study, significant upregulation of WBC counts implicated the immunopotentiation of C. nasus in response to salinity stress. Research studies of Nrf2 on mice and human beings indicated that Nrf2 also played a vital role in protection against inflammation [49][50][51]. Likewise, in this study, the C. nasus Nrf2-mediated antioxidant pathway was activated and further stimulated the upregulation of immune enzymes and molecules, indicating the regulatory role that Nrf2 plays in immunopotentiation in response to salinity stress (Figure 7).…”
Section: Antioxidant Regulation and Immunopotentiation Of C Nasus Nrsupporting
confidence: 60%
“…Importantly, in diabetic cardiomyopathy, piceatannol alleviates inflammation and oxidative stress by regulating the Nrf2/HO-1 and NF-kB pathways. Knockdown of Nrf2 suppressed PIC-induced enhancement of HO-1 expression and abolished the anti-inflammatory effects of PIC [ 15 ]. Moreover, piceatannol attenuates homocysteine-induced apoptosis, oxidative stress, and endoplasmic reticulum stress via Nrf2-dependent HO-1 expression in endothelial cells [ 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Nrf-2 has been considered as an effective regulator of antioxidative genes expression, for example, HO-1 and NQO-1, and in modulating ROS-eliminating enzymes 34 . Many natural compounds with antioxidative properties, such as honokiol 35 , notoginsenoside 36 , and piceatannol 37 , could facilitate the treatment of diabetic complications by activating Nrf-2-mediated signaling pathway. Recently, Yerra et al 16 demonstrated that promoting Nrf-2mediated antioxidative response could mediate the protective effects of ISL on diabetic neuropathy.…”
Section: Discussionmentioning
confidence: 99%