Piceatannol and resveratrol share inhibitory effects on hydrogen peroxide release, monoamine oxidase and lipogenic activities in adipose tissue, but differ in their antilipolytic properties

Les, Francisco; Deleruyelle, Simon; Cassagnes, Laure‐Estelle; Boutin, Jean A.; Balogh, Balázs; Arbonés-Mainar, José M.; Biron, Simon; Marceau, Picard; Richard, Denis; Nepveu, Françoise; Mauriège, Pascale; Carpéné, Christian

doi:10.1016/j.cbi.2016.07.014

Cited by 32 publications

(35 citation statements)

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“…This was definitively not the case in the present study because in none of the tested conditions (mouse or human fat cells, basal or stimulated levels) resveratrol and pterostilbene were clearly able to trigger or to reinforce lipolytic activity. Pterostilbene exhibited only a weak tendency to increase isoprenaline lipolytic action in mouse fat cells, somewhat reproducing the previously reported resveratrol effects (Szkudelska et al , ; Lasa et al , ; Les et al , ). Resveratrol used as a reference polyphenol in our studies even became antilipolytic in mouse adipocytes at the highest tested millimolar dose.…”

Section: Discussionsupporting

confidence: 89%

“…The same vials were used for 120‐min incubation, for lipid extraction in an organic mixture for liquid scintillation that is non‐miscible with water (InstaFluorPlus, PerkinElmer, Waltham, USA), and for counting the neo‐synthesized radioactive lipids. The radiolabelled glucose that remained non‐metabolized by the cells was restrained to the lower phase of the tubes and did not trigger any excitation of the non‐water miscible scintillation cocktail as previously described (Les et al , ).…”

Section: Methodsmentioning

confidence: 99%

“…Pterostilbene (3,5‐dimethoxy‐4′‐hydroxystilbene) was obtained from Sigma‐Aldrich, as it was the case for trans‐resveratrol, caffeine, isoprenaline (also known as isoproterenol) and other reagents, except otherwise stated. Phytochemicals were dissolved in dimethyl sulfoxide (DMSO, from Sigma‐Aldrich) (Les et al , ).…”

Section: Methodsmentioning

confidence: 99%

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Pterostilbene Inhibits Lipogenic Activity similar to Resveratrol or Caffeine but Differently Modulates Lipolysis in Adipocytes

et al. 2017

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The anti-obesity effects of resveratrol shown in rodents are not transposed into an efficient therapy of human obesity. Consequently, the search for molecules mimicking or surpassing resveratrol actions is ongoing. The natural phenolic compound pterostilbene exhibits beneficial health effects and has the capacity to limit fat mass in animal models. In this study, we tested whether pterostilbene modulates triacylglycerol accumulation/breakdown. Prolonged exposure to pterostilbene or resveratrol inhibited adipocyte differentiation in 3T3-F442A preadipocytes. Acute effects on lipolysis, antilipolysis and lipogenesis were determined for pterostilbene in mouse adipocytes, and compared with resveratrol. Pterostilbene was also tested on glycerol release and glucose uptake in subcutaneous human adipocytes. Dose-response analyses did not reveal a clear lipolytic effect in both species. The antilipolytic effect of insulin was improved by pterostilbene at 1-10 μM in mouse fat cells only, while at 1 mM, the phenolic compound was antilipolytic in human fat cells in a manner not additive to insulin. Pterostilbene dose-dependently inhibited glucose incorporation into lipids similarly to resveratrol and caffeine. However, only the former did not inhibit insulin-stimulated glucose uptake. Indeed, pterostilbene abolished the insulin lipogenic effect without inhibiting its antilipolytic action and rapid activation of glucose uptake. Pterostilbene therefore exhibits a unique panel of direct interactions with adipocytes that relies on its reported anti-obesity and antidiabetic properties. Copyright © 2017 John Wiley& Sons, Ltd.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

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Pterostilbene Inhibits Lipogenic Activity similar to Resveratrol or Caffeine but Differently Modulates Lipolysis in Adipocytes

et al. 2017

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“…Incubations were stopped by placing the incubation tubes on ice. As already documented, lipolytic activity was determined by using glycerol release as an index[20], since FFA release follows parallel variations in our experimental conditions[21]. Once the buoyant adipocytes were frosted, 150 μL of medium were removed for glycerol spectrophotometric measurement at 340 nm, after addition of 1.5 mL of chromogenic mixture (0.6 mmol/L NAD, 1.4 mmol/L ATP, 0.2 mol/L glycine, 1 mol/L hydrazine, with 15 unit/mL glycerol phosphate dehydrogenase, and 0.6 unit/mL glycerokinase, pH 9.8), as previously described[22].…”

Section: Methodsmentioning

confidence: 99%

“…De novo lipogenic activity was determined by quantifying the D-[3- 3 H]-glucose incorporation into lipids in mouse fat cells, according to[21]. They were incubated at 37 °C for 120 min in the same incubation medium as above, only containing only 0.6 mmol/L of isotopic glucose dilution as source of carbohydrates.…”

Section: Methodsmentioning

confidence: 99%

Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells

Carpéné

García-Vicente

Serrano

et al. 2017

WJD

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AIMTo assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate (B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids (FFA) and glucose circulating levels.METHODSAdipose tissue (AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents (insulin, benzylamine, vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTSIn all the species studied, B6V10 exhibited a dose-dependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but - similarly to benzylamine - without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells.CONCLUSIONB6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance.

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Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

Jalali

Firouzabadi

Zarshenas

2021

Phytotherapy Research

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Depression is one of the most common mental disorders worldwide. The genetic factors are linked to depression and anti‐depressant outcomes. Traditional Persian medicine (TPM) manuscripts have provided various anti‐depressant remedies, which may be useful in depression management. This review has studied the bioactive compounds, underlying mechanisms, and treatment outcomes of the medicinal plants traditionally mentioned effective for depression from “The storehouse of medicament” (a famous pharmacopeia of TPM) to merge those with the novel genetics science and serve new scope in depression prevention and management. This review paper has been conducted in two sections: (1) Collecting medicinal plants and their bioactive components from “The storehouse of medicament,” “Physician's Desk Reference (PDR) for Herbal Medicines,” and “Google scholar” database. (2) The critical key factors and genes in depression pathophysiology, prevention, and treatment were clarified. Subsequently, the association between bioactive components' underlying mechanism and depression treatment outcomes via considering polymorphisms in related genes was derived. Taken together, α‐Mangostin, β‐carotene, β‐pinene, apigenin, caffeic acid, catechin, chlorogenic acid, citral, ellagic acid, esculetin, ferulic acid, gallic acid, gentiopicroside, hyperoside, kaempferol, limonene, linalool, lycopene, naringin, protocatechuic acid, quercetin, resveratrol, rosmarinic acid, and umbelliferone are suitable for future pharmacogenetics‐based studies in the management of depression.

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Piceatannol and resveratrol share inhibitory effects on hydrogen peroxide release, monoamine oxidase and lipogenic activities in adipose tissue, but differ in their antilipolytic properties

Cited by 32 publications

References 67 publications

Pterostilbene Inhibits Lipogenic Activity similar to Resveratrol or Caffeine but Differently Modulates Lipolysis in Adipocytes

Pterostilbene Inhibits Lipogenic Activity similar to Resveratrol or Caffeine but Differently Modulates Lipolysis in Adipocytes

Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells

Pharmacogenetic‐based management of depression: Role of traditional Persian medicine

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