Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway

Li, Xungang; Zhang, Wensheng; Yan, Xiaoping

doi:10.14715/cmb/2020.66.3.29

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Similarly, TDRG1 elevates cell proliferation and invasion by enhancing PI3K/AKT signal in osteosarcoma [43]. Meanwhile, the study conducted by Li et al ., [44] revealed that piceatannol represses cell proliferation while improves apoptosis through regulation of phosphatase and tensin homolog (PTEN)/AKT signaling in bladder cancer. It is also noteworthy that miR-210, an miRNA, was previously illustrated to stimulate NSCLC migration and invasion by PTEN/PI3K/AKT signal in exosomes [45].…”

Section: Discussionmentioning

confidence: 99%

Heat shock protein 47 promotes cell migration and invasion through AKT signal in non-small cell lung cancer

Xiong

et al. 2021

Anti-Cancer Drugs

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Lung cancer is one of the most lethal malignancies, with the highest number of cases and deaths. Non-small cell lung cancer (NSCLC) is the most ordinary type of pathology in lung cancer. Meanwhile, various researchers have reported that heat shock protein 47 (HSP47) plays a vital regulatory role in cancer. However, the role of HSP47 in NSCLC is not clear. Consequently, the current study set out to investigate the role of HSP47 in the pathogenesis of NSCLC. First, we evaluated the expression patterns of HSP47 in NSCLC cell lines related to human normal lung epithelial cells, and HSP47 was found to be highly expressed in NSCLC cell lines. In addition, inhibiting the expression of HSP47 brought about marked repression in cell proliferation, migration and invasion in PC-9 cells. On the contrary, cell proliferation, migration and invasion were all elevated after over-expression of HSP47. Mechanistical experimentation further illustrated that protein kinase B (AKT) signal was repressed after inhibition of HSP47, and the influence of sh-HSP47 on cell proliferation, migration and invasion was countered by epidermal growth factor. Lastly, in-vivo animal models demonstrated that inhibition of HSP47 repressed cell tumorigenesis and AKT signal. Collectively, our findings illustrated that HSP47 was highly expressed in NSCLC cell lines, whereas inhibition of HSP47 repressed cell migration and invasion by diminishing the AKT signal. Inhibition of HSP47 also exhibited strong therapeutic effects on NSCLC in vivo

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Section: Discussionmentioning

confidence: 99%

Heat shock protein 47 promotes cell migration and invasion through AKT signal in non-small cell lung cancer

Xiong

et al. 2021

Anti-Cancer Drugs

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“…For instance, Peng et al (110) reported the effects of ferulic acid on T24 bladder cancer cells in two-dimensional (2D) and 3D cell culture systems where they found that it dramatically increased apoptosis, and induced much higher cytotoxicity in 3D than in 2D culture systems. Ferulic acid also upregulates anti-oxidative enzymes such as superoxide dismutase, catalase, and pro-apoptotic proteins such as caspase3, cleaved caspase 9, and Bax (111).…”

Section: Cinnamatementioning

confidence: 99%

“…Piceatannol inhibits EJ bladder cancer cell proliferation by arresting the cell cycle in the G0/G1 phase. Moreover, piceatannol induces EJ cell apoptosis through a mechanism associated with the increases in protein expression of phosphatase and tensin homolog in concert with a decrease in the phosphorylation of AKT (111).…”

Section: Stilbenesmentioning

confidence: 99%

Natural Phytochemicals in Bladder Cancer Prevention and Therapy

Xia

Chen

et al. 2021

Front. Oncol.

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Phytochemicals are natural small-molecule compounds derived from plants that have attracted attention for their anticancer activities. Some phytochemicals have been developed as first-line anticancer drugs, such as paclitaxel and vincristine. In addition, several phytochemicals show good tumor suppression functions in various cancer types. Bladder cancer is a malignant tumor of the urinary system. To date, few specific phytochemicals have been used for bladder cancer therapy, although many have been studied in bladder cancer cells and mouse models. Therefore, it is important to collate and summarize the available information on the role of phytochemicals in the prevention and treatment of bladder cancer. In this review, we summarize the effects of several phytochemicals including flavonoids, steroids, nitrogen compounds, and aromatic substances with anticancer properties and classify the mechanism of action of phytochemicals in bladder cancer. This review will contribute to facilitating the development of new anticancer drugs and strategies for the treatment of bladder cancer using phytochemicals.

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Piceatannol induces caspase‐dependent apoptosis by modulating intracellular reactive oxygen species/mitochondrial membrane potential and enhances autophagy in neuroblastoma cells

Güçlü,

Ayan,

Çetinkaya

et al. 2024

J of Applied Toxicology

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The aim of this study was to evaluate the anticancer effects of piceatannol, a natural stilbenoid, on human neuroblastoma cells. In order to accomplish this goal, we performed various cellular assays, including the XTT cell proliferation assay for cell viability, colony formation assay for colony formation capacity, FITC Annexin V and cell death detection kit for apoptosis, matrigel invasion assay for invasion capacity, intracellular reactive oxygen species (ROS) red dye for intracellular ROS levels, TMRM staining method for mitochondrial membrane potential (MMP), and the CYTO‐ID autophagy detection kit for autophagy. Furthermore, we analyzed the expression levels of genes associated with apoptosis and autophagy using RT‐qPCR. Based on our findings, piceatannol exhibited cytotoxic effects on neuroblastoma cells. Besides, treatment with piceatannol at both 50 and 100 μM concentrations for 72 h decreased colony formation, induced apoptosis and autophagy, inhibited cell invasion, decreased MMP, and increased ROS levels in SH‐SY5Y cells. In addition, we observed significant upregulation in the expression levels of CASP8, BECLIN, ATG5, ATG7, and MAPILC3A genes between the two doses. These results suggest that piceatannol enhances autophagic activity and induces caspase‐dependent apoptosis, indicating its potential as a therapeutic agent against neuroblastoma cells.

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Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway

Cited by 5 publications

References 27 publications

Heat shock protein 47 promotes cell migration and invasion through AKT signal in non-small cell lung cancer

Heat shock protein 47 promotes cell migration and invasion through AKT signal in non-small cell lung cancer

Natural Phytochemicals in Bladder Cancer Prevention and Therapy

Piceatannol induces caspase‐dependent apoptosis by modulating intracellular reactive oxygen species/mitochondrial membrane potential and enhances autophagy in neuroblastoma cells

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