Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review

Shah, Naheed Sidiq; Thotathil, Vandana; Zaidi, Shabi Abbas; Sheikh, Hanan; Mohamed, Maimoona; Qureshi, Ahmadyar; Sadasivuni, Kishor Kumar

doi:10.3390/bios12121107

Cited by 18 publications

(8 citation statements)

References 91 publications

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“…Molecular identification constitutes a pivotal event with profound implications across diverse applications. For instance, antibodies and enzymes, quintessential biomolecules, harbor specific recognition sites facilitating interactions with their corresponding antigens and substrates [43][44][45]. These interactions, serving as inspiration, have catalyzed the development of various recognition materials, among which molecularly imprinted polymers (MIPs) hold a significant position.…”

Section: Molecular Imprinting Methodsmentioning

confidence: 99%

Biosensing Applications of Molecularly Imprinted-Polymer-Based Nanomaterials

Saylan,

Kılıç,

Denizli

2024

Processes

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In the realm of sensing technologies, the appeal of sensors lies in their exceptional detection ability, high selectivity, sensitivity, cost-effectiveness, and minimal sample usage. Notably, molecularly imprinted polymer (MIP)-based sensors have emerged as focal points of interest spanning from clinical to environmental applications. These sensors offer a promising avenue for rapid, selective, reusable, and real-time screening of diverse molecules. The preparation technologies employed in crafting various polymer formats, ranging from microparticles to nanomaterials, wield a profound influence. These techniques significantly impact the assembly of simplified sensing systems, showcasing remarkable compatibility with other technologies. Moreover, they are poised to play a pivotal role in the realization of next-generation platforms, streamlining the fabrication of sensing systems tailored for diverse objectives. This review serves as a comprehensive exploration, offering concise insights into sensors, the molecular imprinting method, and the burgeoning domain of MIP-based sensors along with their applications. Delving into recent progress, this review provides a detailed summary of advances in imprinted-particle- and gel-based sensors, illuminating the creation of novel sensing systems. Additionally, a thorough examination of the distinctive properties of various types of MIP-based sensors across different applications enriches the understanding of their versatility. In the concluding sections, this review highlights the most recent experiments from cutting-edge studies on MIP-based sensors targeting various molecules. By encapsulating the current state of research, this review acts as a valuable resource, offering a snapshot of the dynamic landscape of MIP-based sensor development and its potential impact on diverse scientific and technological domains.

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Section: Molecular Imprinting Methodsmentioning

confidence: 99%

Biosensing Applications of Molecularly Imprinted-Polymer-Based Nanomaterials

Saylan,

Kılıç,

Denizli

2024

Processes

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Section: Figurementioning

confidence: 99%

“…Several polymerization methods have been used to fabricate MIPs, among which are free radical polymerization (FRP), controlled radical polymerization (CRP), sol-gel process, electropolymerization, and photopolymerization [ 25 ]. Free radical polymerization is a common method used to fabricate MIPs and requires the use of a radical initiator with a template and monomer [ 26 , 27 ]. However, the control of the reactions of propagation and termination is difficult, resulting in different polymer chain lengths and branching.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Ostrovidov

Ramalingam

Bae

et al. 2023

Sensors

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Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives.

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“…At present, electrochemical sensors are some of the most effectively used MIP-based devices [41][42][43][44][45][46][47][48][49][50][51], and different strategies have been proposed for integrating MIPs with the electrodes. Surface imprinting is, so far, the most commonly used approach.…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid Sensing by Molecularly Imprinted Electrosynthesized Polymer (e-MIP) on Screen-Printed Electrodes

et al. 2023

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This paper presents the development of a cheap and rapid electrochemical sensor for ascorbic acid detection. In particular, the graphite ink working electrode of screen-printed cells was covered by a film of elecrosynthesized molecularly imprinted polypyrrole (e-MIP); differential pulse voltammetry (DPV) was the selected method for the analyte detection. The ascorbic acid molecules were successfully entrapped in the polypyrrole film, creating the recognition sites. The best results were obtained after polypyrrole overoxidation and performing the measurements in phosphate buffer solution 0.05 M/KCl 0.1 M at pH 7.5. A comparison with the bare and the not-imprinted polypyrrole-modified electrodes showed that the e-MIP-based sensor had the highest selectivity and reproducibility. The developed method was applied to assess ascorbic acid in farmaceutical products, obtaining values not significantly different from the declared content.

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Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review

Cited by 18 publications

References 91 publications

Biosensing Applications of Molecularly Imprinted-Polymer-Based Nanomaterials

Biosensing Applications of Molecularly Imprinted-Polymer-Based Nanomaterials

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Ascorbic Acid Sensing by Molecularly Imprinted Electrosynthesized Polymer (e-MIP) on Screen-Printed Electrodes

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