Picornarvirus Receptors in Pathogenesis

Crowell, Richard L.; Landau, Burton J.; Siak, J S

doi:10.1007/978-94-011-8022-1_9

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…The interactions of FMDV with cells have been extensively studied for many years. It is generally accepted that FMDV receptors, as well as other picornavirus receptors, play a role in tissue and organ tropism which leads to disease pathogenesis (112,151,429,476). FMDV binds rapidly to cells in culture at both 4 and 37°C by using a limited number of receptor sites, which has measured at between 10 3 and 10 4 per cell (39).…”

Section: Infectious Cyclementioning

confidence: 99%

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Foot-and-Mouth Disease

2004

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Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. The disease was initially described in the 16th century and was the first animal pathogen identified as a virus. Recent FMD outbreaks in developed countries and their significant economic impact have increased the concern of governments worldwide. This review describes the reemergence of FMD in developed countries that had been disease free for many years and the effect that this has had on disease control strategies. The etiologic agent, FMD virus (FMDV), a member of the Picornaviridae family, is examined in detail at the genetic, structural, and biochemical levels and in terms of its antigenic diversity. The virus replication cycle, including virus-receptor interactions as well as unique aspects of virus translation and shutoff of host macromolecular synthesis, is discussed. This information has been the basis for the development of improved protocols to rapidly identify disease outbreaks, to differentiate vaccinated from infected animals, and to begin to identify and test novel vaccine candidates. Furthermore, this knowledge, coupled with the ability to manipulate FMDV genomes at the molecular level, has provided the framework for examination of disease pathogenesis and the development of a more complete understanding of the virus and host factors involved

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Section: Infectious Cyclementioning

confidence: 99%

“…It has been recognized for many years that viral receptors play a role in tissue tropism and disease pathogenesis (112,151,429,476). In "Early interactions: adsorption, penetration, and uncoating" above, we discussed the viral integrin receptors that have been identified and the ability of FMDV to utilize alternative receptors.…”

Section: Virulence Factorsmentioning

confidence: 99%

Foot-and-Mouth Disease

2004

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“…The group B coxsackieviruses and especially CB4 are of particular interest in that they have been associated with type I juvenile onset or insulin-dependent diabetes mellitus (Yoon et al, 1979;King et al, 1983;BarretConnor, 1985;Frisk et al, 1985). The molecular basis of the tissue tropism of these viruses is not well understood, although there is some evidence to suggest that for the picornaviruses generally, a major determinant is the affinity of the viruses for a specific cellular receptor on the surface of the target cell (see Crowell et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

The Complete Nucleotide Sequence of Coxsackievirus B4 and Its Comparison to Other Members of the Picornaviridae

Jenkins

Booth

Minor

et al. 1987

Journal of General Virology

200

112

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SUMMARYThe genome of the prototype strain of coxsackievirus B4 (J.V.B. Benschoten) has been cloned in Escherichia coil and its complete nucleotide sequence determined. Excluding the poly(A) tract, the RNA genome is 7395 nucleotides in length and appears to encode a single polyprotein of 2183 amino acids. The predicted amino acid sequence of the polyprotein shows close homology (88~) to that of the previously sequenced coxsackievirus B3 and to certain regions of the polyproteins of the polioviruses and human rhinovirus 14. This allows identification of putative polyprotein cleavage signals, antigenic domains and other structural features likely to be important to the biological integrity of the virus.

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“…The polioviruses provide an example of this type of specific virus-host cell interaction. Normally, polioviruses infect only primates, and can replicate in all cells of primate origin growing in cell culture (for review, see Crowell et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Production of a Monoclonal Antibody against an Epitope on HeLa Cells that Is the Functional Poliovirus Binding Site

Nobis

Zibirre

Meyer

et al. 1985

Journal of General Virology

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SUMMARYCell lines of primate origin carry receptors on their plasma membrane which are responsible for the specific binding of poliovirus.This paper describes the isolation and characterization of a monoclonal antibody reacting with the plasma membrane of HeLa ceils. The antibody (D171) was selected for its protection of HeLa cells against the cytopathic effect of poliovirus type 1. This protection was found to extend to all three viral serotypes, while the replication of five other viruses in HeLa cells was not affected. The 125i_labelled purified antibody did not react with cell lines derived from pig, dog or rodents but bound specifically to all lines of human or primate origin. Immunoglobulin or Fab fragments of DI71 prevented the binding of 35S-labelled poliovirus to HeLa cells. Conversely, nearly all binding sites of 125I-labelled D171 immunoglobulins or Fab fragments could be blocked after preincubation of HeLa cells with poliovirus. These results indicate that D 171 recognizes the poliovirus receptor site on different susceptible cells and that practically all D171 binding sites are involved in the specific attachment of poliovirus to the plasma membrane. To determine whether the epitope recognized by D171 could be separated from the receptor for poliovirus, human-mouse cell hybrids were prepared and analysed. In all 40 clones tested, the susceptibility to poliovirus correlated with the binding of D171.

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Picornarvirus Receptors in Pathogenesis

Cited by 8 publications

References 57 publications

Foot-and-Mouth Disease

Foot-and-Mouth Disease

The Complete Nucleotide Sequence of Coxsackievirus B4 and Its Comparison to Other Members of the Picornaviridae

Production of a Monoclonal Antibody against an Epitope on HeLa Cells that Is the Functional Poliovirus Binding Site

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