2014
DOI: 10.3892/ijmm.2014.2009
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Picroside II inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by ameliorating mitochondrial function through a mechanism involving a decrease in reactive oxygen species production

Abstract: Reactive oxygen species (ROS)‑induced mitochondrial dysfunction plays an important role in cardiomyocyte apoptosis during myocardial ischemia/reperfusion (I/R) injury. Picroside Ⅱ, isolated from Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been reported to protect cardiomyocytes from hypoxia/reoxygenation (H/R)‑induced apoptosis, but the exact mechanism is not fully clear. The aim of the present study was to explore the protective effects of picroside Ⅱ on H/R‑induced cardiomyocyte apoptosis an… Show more

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Cited by 14 publications
(6 citation statements)
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“…The roots of this plant are of benefit, and as a traditional medicine, it is used for a number of conditions . Picroside II (P‐II), one of the main active components of scrophularia extract, has shown its anti‐oxidative, anti‐inflammatory effects . However, whether P‐II could inhibit HHcy‐induced endothelial injuries has not been studied.…”
Section: Introductionmentioning
confidence: 99%
“…The roots of this plant are of benefit, and as a traditional medicine, it is used for a number of conditions . Picroside II (P‐II), one of the main active components of scrophularia extract, has shown its anti‐oxidative, anti‐inflammatory effects . However, whether P‐II could inhibit HHcy‐induced endothelial injuries has not been studied.…”
Section: Introductionmentioning
confidence: 99%
“…These studies suggested that picroside II has an anti-inflammation property. Furthermore, studies from our laboratory (Central South University, Changsha, China) and others have demonstrated that picroside II has a protective effect on H/R- or I/R-induced cardiomyocyte injury (17,18), however, the exact mechanism remains unclear. Due to the important role of the inflammatory response in the pathogenesis of myocardial I/R injury and the anti-inflammatory property of picroside II, we hypothesize that the protective mechanism of picroside II on myocardial I/R injury may be associated with the inhibition of the inflammatory response.…”
Section: Discussionmentioning
confidence: 98%
“…Recently, it has been reported that picroside II has a protective effect on myocardial I/R injury in rats (17). Furthermore, our previous investigation also demonstrated that picroside II was able to inhibit hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis (18); however, the exact mechanism underlying the cardioprotective effects of picroside II in myocardial I/R injury is not fully understood.…”
Section: Introductionmentioning
confidence: 99%
“…The loss of functional cardiomyocyte leads to secondary damages that interfere with recovery from myocardial infraction. Previous studies showed that the mechanisms underlying myocardial I/R injury might be associated with calcium overload and mitochondrial dysfunction [25], an increase in reactive oxygen species [26], activation and adhesion of neutrophils [27], or cellular apoptosis [28]. Others have reported that NGF delivered during reperfusion protects the heart from MIRI [23, 29, 30], but the mechanism by which NGF regulates cardiomyocyte survival and function remains to be elucidated.…”
Section: Discussionmentioning
confidence: 99%