Piebaldism

Disorders of pigmentation

“…6,15 The chalk-white areas of hypomelanosis involve the anterior part of the trunk, the mid-region of the extremities, the forehead, and the mid-frontal area of the scalp beneath a white forelock. 16 Regression of the white forelock has also been reported. 16 Regression of the white forelock has also been reported.…”

“…123 Many cases of depigmentation, some resembling vitiligo, have been reported following the use of the tyrosine kinase inhibitor imatinib, used in the treatment of chronic myeloid leukemia. 16,35,36 The successful use of autologous grafts to repigment the affected areas is not inconsistent with these theories. It appears to be required, in humans, for melanocyte proliferation.…”

Piebaldism: an autonomous autosomal dominant entity

“…It has been suggested that a defect in migration or differentiation of melanocytes is responsible (Comings & Odland 1966). Histological and ultrastructural abnormalities documented in both piebaldism and the Waardenburg syndrome are replacement of melanocytes and melanosomes by Langerhans cells (Comings & Odland 1966, Mosher & Fitzpatrick 1988, although Hayashibe & Mishima (1988) have found that regularly placed junction melanocytes may be cvident in the hypomelanotic skin. Histopathological studies in our patients confirmed the classical view; melanocytic activity was reduced in the areas of lesser pigmentation and absent in the totally depigmented areas.…”

Hereditary hypo/de‐pigmented dermatoses: An overview

“…Piebaldism is a rare disorder with congenital hypomelanosis transmitted by the widely distributed autosomal dominant gene which affect the differentiation and migration of melanoblasts 5,61–64 . Clinically, depigmented skin lesions are present at birth which remain unchanged throughout life.…”