Pielonefritis xantogranulomatosa: Estudio retrospectivo de 8 casos

Abstract

Introducción La pielonefritis xantogranulomatosa (PNX) fue descrita por primera vez en 1916 por Schlagenhaufer (4). Se trata de una forma infrecuente de infección crónica renal que afecta principalmente de forma difusa y en escasas ocasiones con distribución focal (1-3) , siendo necesario en estos casos realizar el diagnóstico diferencial con las neoplasias renales. Se ha asociado a distintos mecanismos etiopatogénicos como son la obstrucción crónica del tracto urinario, hemorragia, insuficiencia arterial, obstrucción venosa, alteración del sistema inmune, alteración del metabolismo de los lípidos, hiperparatiroidismo y diabetes mellitus (2,3,5-7). La entidad es más prevalente entre la quinta y séptima década de la vida y más frecuente en mujeres (70%), a excepción de aquellas que se producen a edades tempranas que no presentan diferencia entre sexos (2,3). La clínica es inespecífica y de evolución tórpida, destacando síntomas como astenia, pérdida de peso, dolor en fosa renal y febrícula recurrente. En la ex

Xanthogranulomatous Pyelonephritis, a Great Imitator: Case Report

“…In agreement with other publications [5][6][7] the paraclinical tests showed altered liver function, with hypoalbuminemia, decreased total proteins, slight prolongation of PT, elevation of alkaline phosphatase, TGO and direct bilirubin, which returned to normal once the pathology was treated.…”

“…For this therapy to be effective, it is of vital importance to have the bacterial agents well identified through a urine culture with its respective antibiogram. However, the final treatment is always surgical, performing total or partial nephrectomy as appropriate [2,5,7].…”

“…Anemia, leukocytosis, hematuria, and pyuria are the most frequent laboratory findings in the majority of published case series [2,5,7].…”

“…Confirmation diagnosis is histological, characterized by poor corticomedullary differentiation on cut, at the microscopic level it shows an acute inflammatory infiltration with a predominance of polymorphonuclear cells with intracytoplasmic lipid-laden macrophages (foamy macrophages or xanthogranulomatous cells) and multinucleated giant cells, a characteristic histopathological image that name the entity [7,8].…”

Combination of Texture and Shape Features Using Machine and Deep Learning Algorithms for Breast Cancer Diagnosis

“…The main disadvantage of CLAHE method is the tendency to over-amplify noise in homogeneous regions in the case of mammographic images, so, the proposed algorithm do not perform very well. Besides, in Soriano et al [6] a comparison of two different schemes of mammogram classification based on CNN was developed. The main difference between these two schemes is based on the number of bits per image pixel, and the proposed feature extraction approaches.…”