Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

Abstract

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity of nanozymes and improve the therapeutic effect of nanozyme catalytic therapy. Piezoelectric materials, which are capable of generating a built-in electric field under ultrasound (US), not only improve the activity of nanozymes but also enable piezoelectric sonodynamic therapy (SDT). In this study, a sonosensitizer based on a Hf-based metal−organic framework (UIO-66) and Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate a built-in electric field inside the materials, which promotes electron− hole separation and produces reactive oxygen species (ROS). The introduction of Au NPs facilitated the electron transfer, which inhibited the recombination of the electron−hole pairs and improved the piezoelectric properties of UIO-66. The value of the piezoelectric constant (d 33 ) increased from 71 to 122 pmV −1 after the deposition of Au NPs. In addition, the intrinsic catalase and peroxidase activities of the Au NPs were increased 2-fold after the stimulation from the built-in electric field induced through US exposure. In vivo and in vitro experiments revealed that the proposed sonosensitizer can kill cancer cells and inhibit tumor growth in mice through the enhanced piezoelectric SDT and nanozyme catalytic therapy. The piezoelectric sensitizer proposed in this work proved to be an efficient candidate that can be used for multiple therapeutic modalities in tumor therapy.

Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

“…Reproduced with permission. [102] Copyright 2023, American Chemical Society. c) rGO@UIO-66/PCL scaffolds and the mechanism of immunometabolism reprogramming.…”

The rational design of nanozymes for imaging-monitored cancer therapy

“…Nanozymes are widely used as nanotheranostics in tumor therapy that utilizes the high catalytic activity. 115–117 The unique tumor microenvironment (high H 2 O 2 and GSH concentration, low pH, etc. ) endows the nanozymes with activatable catalytic ability.…”

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

“…It should be emphasized that the intrinsic nanozyme activity is another crucial factor in the DFU treatment. By introducing an external field, the nanozyme activity can be considerably boosted and precisely regulated through coupling nanozyme involved catalysis and external field driven catalysis. − Ultrasound (US) is widely utilized in clinical practice for diagnosis and treatment because of its noninvasive nature, low energy attenuation, and high penetration ability into tissues. − Recently, some ultrasound-augmented nanozymes for infection treatment have been reported, − which can absorb a large amount of energy released from cavitation bubbles, induce carrier separation and energy band bending in nanozyme surfaces to enhance the nanozyme activity. In addition, ultrasound triggers the formation of transient pores in biofilm matrix, which increases the diffusion of nanozymes into biofilms and improves treatment efficacy. , To reinforce the delivery efficiency, nanozymes can be encapsulated in hydrogel, , which provides a moist microenvironment and fills irregular wounds, hence promoting diabetic wound healing. − …”