Pig HDL-binding protein (HDLBP) genotype is associated with intramuscular fat percentage

Cánovas, E.; Quintanilla, Raquel; Badaoui, Bouabid; Porredón, C.; Gallardo, David; Pena, Ramona N.; Dı́az, Isabel; Amills, Marcel

doi:10.1016/j.livsci.2009.06.005

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…In pigs, peroxisome proliferator-activated receptor gamma coactivator-1α ( PGC1α ) is associated with IMF content [ 10 ]. HDL-binding protein ( HDLBP ) is also associated with IMF percentage [ 11 ]. In male Kazak sheep, the mRNA expression level of heart-type fatty acid binding protein ( FABP3 ) is highly and positively correlated with IMF content, but that of PPARγ is highly and negatively correlated with IMF content [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages

Lin¹,

Zhu²,

Wang³

et al. 2017

PLoS ONE

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Intramuscular fat (IMF) content and fatty acid composition of longissimus dorsi muscle (LM) change with growth, which partially determines the flavor and nutritional value of goat (Capra hircus) meat. However, unlike cattle, little information is available on the transcriptome-wide changes during different postnatal stages in small ruminants, especially goats. In this study, the sequencing reads of goat LM tissues collected from kid, youth, and adult period were mapped to the goat genome. Results showed that out of total 24 689 Unigenes, 20 435 Unigenes were annotated. Based on expected number of fragments per kilobase of transcript sequence per million base pairs sequenced (FPKM), 111 annotated differentially expressed genes (DEGs) were identified among different postnatal stages, which were subsequently assigned to 16 possible expression patterns by series-cluster analysis. Functional classification by Gene Ontology (GO) analysis was used for selecting the genes showing highest expression related to lipid metabolism. Finally, we identified the node genes for lipid metabolism regulation using co-expression analysis. In conclusion, these data may uncover candidate genes having functional roles in regulation of goat muscle development and lipid metabolism during the various growth stages in goats.

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Section: Introductionmentioning

confidence: 99%

Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages

Lin¹,

Zhu²,

Wang³

et al. 2017

PLoS ONE

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“…However, selection for leanness over the last 21 years in swine has decreased intramuscular fat and adversely influenced pork flavor and color ( Schwab et al, 2006 ). Recently, intramuscular adipose tissue has attracted more attentions of the researchers, in attempt to maintain or improve the meat quality, by the high demand for the marbling fat ( Gerbens et al, 2000 ; Cánovas et al, 2009 ; Cordero et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Thiazolidinedione Supplementation on Growth Performance, Intramuscular Fat and Related Genes mRNA Abundance in the Longissimus Dorsi Muscle of Finishing Pigs

Chen

Yuan

Yang

et al. 2013

Asian Australas. J. Anim. Sci

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The objective of this study was to investigate the effect of dietary supplementation with thiazolidinedione (TZD) on growth performance and meat quality of finishing pigs. In Experiment 1, 80 castrated finishing pigs (Large White×Landrace, BW = 54.34 kg) were randomly assigned to 2 treatments with 5 replicates of 8 pigs each. The experimental pigs in the 2 groups were respectively fed with a diet with or without a TZD supplementation (15 mg/kg). In Experiment 2, 80 castrated finishing pigs (Large White×Landrace, BW = 71.46 kg) were divided into 2 treatments as designed in Experiment 1, moreover, carcass evaluations were performed. The results from Experiment 1 showed that TZD supplementation could significantly decreased the average daily feed intake (ADFI) (p<0.05) during 0 to 28 d, without impairing the average daily gain (ADG) (p>0.05). In Experiment 2, the ADG was significantly increased by TZD supplementation during 14 to 28 d and 0 to 28 d (p<0.05) and the feed:gain ratio (F:G) was significantly decreased by TZD supplementation during 0 to 28 d (p<0.05). Compared with the control group, TZD group had significantly higher serum triglyceride (TG) concentration at 28h and serum high-density lipoprotein (HDL) levels at 14 d (p<0.05). Moreover, there was an apparent improvement in the marbling score (p<0.10) and intramuscular fat (IMF) content (p<0.10) of the longissimus dorsi muscle in pigs treated by TZD supplementation. Real-time RT-PCR analyses demonstrated that pigs of TZD group had higher mRNA abundance of PPARγ coactivator 1 (PGC-1) (p<0.05) and fatty acid-binding protein 3 (FABP3) (p<0.05) than pigs of control group. Taken together, these results suggested that dietary TZD supplementation could improve growth performance and increase the IMF content of finishing pigs through regulating the serum parameters and genes mRNA abundance involved in fat metabolism.

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“…The peak on BTA3 (120,425,644–120,435,644 bp) explains 1.65% and 2.22% of the genetic variation in the additive and Brahman dominance GWAS. This region overlaps the gene encoding for the high density lipoprotein binding protein ( HDLBP ), which is a candidate gene for intramuscular fat in pigs [ 49 ]. HDLBP was seen to be upregulated in tender meat in Nellore cattle [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Breed of origin analysis in genome-wide association studies: enhancing SNP-based insights into production traits in a commercial Brangus population

Zayas,

Rodriguez,

Hernandez

et al. 2024

BMC Genomics

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Background Carcass weight (HCW) and marbling (MARB) are critical for meat quality and market value in beef cattle. In composite breeds like Brangus, which meld the genetics of Angus and Brahman, SNP-based analyses have illuminated some genetic influences on these traits, but they fall short in fully capturing the nuanced effects of breed of origin alleles (BOA) on these traits. Focus on the impacts of BOA on phenotypic features within Brangus populations can result in a more profound understanding of the specific influences of Angus and Brahman genetics. Moreover, the consideration of BOA becomes particularly significant when evaluating dominance effects contributing to heterosis in crossbred populations. BOA provides a more comprehensive measure of heterosis due to its ability to differentiate the distinct genetic contributions originating from each parent breed. This detailed understanding of genetic effects is essential for making informed breeding decisions to optimize the benefits of heterosis in composite breeds like Brangus. Objective This study aims to identify quantitative trait loci (QTL) influencing HCW and MARB by utilizing SNP and BOA information, incorporating additive, dominance, and overdominance effects within a multi-generational Brangus commercial herd. Methods We analyzed phenotypic data from 1,066 genotyped Brangus steers. BOA inference was performed using LAMP-LD software using Angus and Brahman reference sets. SNP-based and BOA-based GWAS were then conducted considering additive, dominance, and overdominance models. Results The study identified numerous QTLs for HCW and MARB. A notable QTL for HCW was associated to the SGCB gene, pivotal for muscle growth, and was identified solely in the BOA GWAS. Several BOA GWAS QTLs exhibited a dominance effect underscoring their importance in estimating heterosis. Conclusions Our findings demonstrate that SNP-based methods may not detect all genetic variation affecting economically important traits in composite breeds. BOA inclusion in genomic evaluations is crucial for identifying genetic regions contributing to trait variation and for understanding the dominance value underpinning heterosis. By considering BOA, we gain a deeper understanding of genetic interactions and heterosis, which is integral to advancing breeding programs. The incorporation of BOA is recommended for comprehensive genomic evaluations to optimize trait improvements in crossbred cattle populations.

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Pig HDL-binding protein (HDLBP) genotype is associated with intramuscular fat percentage

Cited by 7 publications

References 13 publications

Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages

Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages

Effects of Dietary Thiazolidinedione Supplementation on Growth Performance, Intramuscular Fat and Related Genes mRNA Abundance in the Longissimus Dorsi Muscle of Finishing Pigs

Breed of origin analysis in genome-wide association studies: enhancing SNP-based insights into production traits in a commercial Brangus population

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