Pig islets for clinical islet xenotransplantation

Dufrane, Denis; Gianello, Pierre

doi:10.1097/mnh.0b013e328331a8e3

Cited by 22 publications

(8 citation statements)

References 76 publications

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“…However, there is a severe shortage of human donors . To overcome this obstacle, xenogeneic islet transplantation may be an alternative to allogeneic islet transplantation . For xenogeneic islet transplantation, pig is usually chosen as the donor, because human and pig insulin are similar, and pig insulin has a long history of use in humans confirming its efficacy .…”

Section: Introductionmentioning

confidence: 99%

Islet‐derived damage‐associated molecular pattern molecule contributes to immune responses following microencapsulated neonatal porcine islet xenotransplantation in mice

Itoh

Hata

Nishinakamura

et al. 2016

Xenotransplantation

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Section: Introductionmentioning

confidence: 99%

Islet‐derived damage‐associated molecular pattern molecule contributes to immune responses following microencapsulated neonatal porcine islet xenotransplantation in mice

Itoh

Hata

Nishinakamura

et al. 2016

Xenotransplantation

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“…Surface heparinization protected islets from IBMIR in an allogeneic setting (65). Encapsulation offers a means of protecting the xenograft from direct exposure to recipient blood and thus avoiding IBMIR altogether (66, 67), as does the use of alternative transplant sites (68–70). …”

Section: Treatment Options To Control Coagulation Dysregulationmentioning

confidence: 99%

Controlling coagulation dysregulation in xenotransplantation

Cowan

Robson

d’Apice

2011

Current Opinion in Organ Transplantation

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Purpose of review Deletion of the α1,3-galactosyltransferase (GalT) gene in pigs has removed a major xenoantigen but has not eliminated the problem of dysregulated coagulation and vascular injury. Rejecting GalT KO organ xenografts almost invariably show evidence of thrombosis and platelet sequestration, and primate recipients frequently develop consumptive coagulopathy (CC). This review examines recent findings that illuminate potential mechanisms of this current barrier to successful xenotransplantation. Recent findings The coagulation response to xenotransplantation differs depending on the type of organ and quite likely the distinct vasculatures. Renal xenografts appear more likely to initiate CC than cardiac xenografts, possibly reflecting differential transcriptional responses. Liver xenografts induce rapid and profound thrombocytopenia resulting in recipient death within days due to bleeding; ex vivo data suggest that liver endothelial cells and hepatocytes are responsible for platelet consumption by a coagulation-independent process. It has been proposed that expression of recipient tissue factor on platelets and monocytes is an important trigger of CC. Finally, pigs transgenic for human anticoagulants and antithrombotics are slowly but surely coming on line, but have not yet been rigorously tested to date. Summary Successful control of coagulation dysregulation in xenotransplantation may require different combinatorial pharmacological and genetic strategies for different organs.

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“…After in vitro culture (usually 4-9 d), tissue from one neonatal pancreas can yield about 50 000 NPI aggregates, consisting of fully differentiated pancreatic endocrine cells (approximately 35%) and endocrine precursor cells (approximately 57%) (Korbutt et al, 1996;Rajotte, 2008;Dufrane and Gianello, 2009). NPIs are able to functionally correct hyperglycemia in diabetic recipients, which is mainly due to β cell proliferation and/or striking differentiation of precursor cells into β cells (Korbutt et al, 1996;Yoon et al, 1999;Trivedi et al, 2001;Nielsen et al, 2003).…”

Section: Neonatal Pig Isletmentioning

confidence: 99%

异种胰岛移植中供体猪的筛选: 现状与进展

Zhu

Lyu

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xenoantigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.

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Pig islets for clinical islet xenotransplantation

Abstract: Pig islet xenotransplantation, however, must still overcome the selection of a suitable pig donor to translate preclinical findings into clinical applications. This review summarizes the actual acquired knowledge of pig islet transplantation in primates to select the 'ideal' pig donor.

Cited by 22 publications

References 76 publications

Islet‐derived damage‐associated molecular pattern molecule contributes to immune responses following microencapsulated neonatal porcine islet xenotransplantation in mice

Islet‐derived damage‐associated molecular pattern molecule contributes to immune responses following microencapsulated neonatal porcine islet xenotransplantation in mice

Controlling coagulation dysregulation in xenotransplantation

异种胰岛移植中供体猪的筛选: 现状与进展

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