Pigment Production by Filamentous Fungi on Agro-Industrial Byproducts: an Eco-Friendly Alternative

Lopes, Fernanda Cortez; Tichota, Deise Michele; Pereira, Jamile Queiroz; Segalin, Jéferson; Rios, Alessandro de Oliveira; Brandelli, Adriano

doi:10.1007/s12010-013-0392-y

Cited by 74 publications

(30 citation statements)

References 30 publications

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“…This strategy may represent an added value to the industry and also helps in solving pollution problems, reducing or preventing their disposal in the environment [1,66,67].…”

Section: Melaninmentioning

confidence: 99%

Production of Melanin Pigment by Fungi and Its Biotechnological Applications

Sponchiado¹,

Sousa²,

Andrade³

et al. 2017

Melanin

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Production of the microbial pigments is one of the emerging fields of research due to a growing interest of the industry for safer products, easily degradable and eco-friendly. Fungi constitute a valuable source of pigments because they are capable of producing high yields of the substance in the cheap culture medium, making the bioprocess economically viable on the industrial scale. Some fungal species produce a dark-brown pigment, known as melanin, by oxidative polymerization of phenolic compounds, such as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol or 1,8-dihydroxynaphthalene (DHN) or 3,4-dihydroxyphenylalanine (DOPA). This pigment has been reported to act as "fungal armor" due to its ability to protect fungi from adverse conditions, neutralizing oxidants generated in response to stress. Apart from the scavenging activity, melanin exhibits other biological activities, including thermoregulatory, radio-and photoprotective, antimicrobial, antiviral, cytotoxic, anti-inflammatory, and immunomodulatory. Studies have shown that the media composition and cultivation conditions affect the pigment production in fungi and the manipulation of these parameters can result in an increase in pigment yield for large-scale pigment production. This chapter presents a comprehensive discussion of the research on fungal melanin, including the recently discovered biological activities and the potential use of this pigment for various biotechnological applications in the fields of biomedicine, dermocosmetics, materials science, and nanotechnology.

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“…This strategy may represent an added value to the industry and also helps in solving pollution problems, reducing or preventing their disposal in the environment [1,66,67].…”

Section: Melaninmentioning

confidence: 99%

Production of Melanin Pigment by Fungi and Its Biotechnological Applications

Sponchiado¹,

Sousa²,

Andrade³

et al. 2017

Melanin

View full text Add to dashboard Cite

show abstract

“…Some of the compounds are applicable as food additives (pigments) or pharmaceuticals (mevinolin, monacolin) (Juzlova et al ., ). Monascus produces three types of pigment, yellow (ankaflavin and monascin), orange (monascorubin and rubropunctatin) and red‐purple (monascorubramine and rubropunctamine) and that can be useful as food colourant (Lopes et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the cultivation mode on red pigments production from Monascus ruber

Hajjaj

Goma

François

2015

Int J of Food Sci Tech

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Summary In submerged cultures performed in chemically defined fermentation medium containing glucose and glutamate, the growth and production of water‐soluble red pigments and citrinin by the filamentous fungus Monascus ruber were studied under various carbon/nitrogen (C/N) ratios. The specific production of the red pigments was optimal at a glucose/glutamate ratio of about 10 and then steadily decreased at higher C/N ratio. In contrast, the production of the mycotoxin increased with increased C/N with an optimum in the range of 30–45. In a fed‐batch mode, it was also found that the production of pigments was not favoured in fed‐batch mode by feeding the medium with glucose while keeping the C/N ratio lower than 10. This low production likely resulted from concurrent high accumulation of L‐malic acid that was reported to inhibit this production. In contrast, this mode of cultivation was rather favourable for the production of the mycotoxin.

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“…These pigments also possess the potential to act as antibiotics, anticancer, antiproliferative, and immunosuppressive compounds. Pigments from Fusarium graminearum [6] and Fusarium fujikuroi [7] have been studied. Bikaverin pigment productions by many Fusarium strains and its clinical applications have been carried out [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial Susceptibility of the Pigment by Fusarium chlamydosporum against Emerging Nosocomial and Opportunistic Pathogens

Thomas¹

2018

IJRASET

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The present study was carried out to evaluate the antimicrobial efficacy of the pigment produced by the fungus, Fusarium chlamydosporum against the emerging Nosocomial and Opportunistic pathogens which were procured from the , and Candida albicans ATCC®10231 TM. The fungus was procured from the National Fungal Culture Collection Institute (NFCCI), Pune with the Accession number, 3020, and was cultivated in an optimised media for its pigment production. The intracellular pigment produced by F. chlamydosporum was extracted using chloroform and subjected for partial purification via Thin Layer Chromatographic technique. The purified extracts of the fungus were assessed for the Minimum Inhibitory Concentration (MIC) using the Kirby Bauer method. Different dilutions of the extract ranging from the concentrations 5000 µg/ml to 9.7 µg/ml were used. Appropriate positive and negative controls were used in the analysis as per the CLSI standards. The pigment exhibited an excellent antimicrobial actiivty against MRSA (MIC at 39 µg/ml), ESBL E. coli (MIC at 625 µg/ml), A. baumanii (MIC at 312.5 µg/ml), S. marcescens (MIC at 39 µg/ml), and C. albicans (MIC at 312.5µg/ml whereas the pigment showed a negative response against P. aeruginosa. These results suggest that the pigment produced by F. chlamydosporum is a potent metabolite which can be used for various applications in the medical field against the emerging drug resistance and Nosocomial pathogens.

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Pigment Production by Filamentous Fungi on Agro-Industrial Byproducts: an Eco-Friendly Alternative

Cited by 74 publications

References 30 publications

Production of Melanin Pigment by Fungi and Its Biotechnological Applications

Production of Melanin Pigment by Fungi and Its Biotechnological Applications

Effect of the cultivation mode on red pigments production from Monascus ruber

Evaluation of Antimicrobial Susceptibility of the Pigment by Fusarium chlamydosporum against Emerging Nosocomial and Opportunistic Pathogens

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