Pigmented eccrine porocarcinoma: a mimic of malignant melanoma

Hara, Kazuo; Kamiya, Satoaki

doi:10.1111/j.1365-2559.1995.tb00298.x

Cited by 35 publications

(25 citation statements)

References 2 publications

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“…Examples of melanocytic colonization in skin tumors include pigmented squamous cell carcinoma, 12 adnexal neoplasms with pilar differentiation (pigmented basal cell carcinoma, 13 melanocytic matricoma, 14 and melanotrichoblastoma 15 ), and adnexal neoplasms with sweat gland differentiation, such as pigmented eccrine porocarcinoma. 16 In these tumors the melanocytes are usually highly pigmented, have a dendritic configuration, and lack cytologic atypia. In our cases the melanocytes present in the tumor nests were clearly atypical, their configuration was not particularly dendritic, and their degree of pigmentation was minimal.…”

Section: Discussionmentioning

confidence: 99%

Combined High-Grade Basal Cell Carcinoma and Malignant Melanoma of the Skin (???Malignant Basomelanocytic Tumor???)

Rodríguez¹,

Nonaka

Kuhn

et al. 2005

The American Journal of Dermatopathology

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We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.

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Section: Discussionmentioning

confidence: 99%

Combined High-Grade Basal Cell Carcinoma and Malignant Melanoma of the Skin (???Malignant Basomelanocytic Tumor???)

Rodríguez¹,

Nonaka

Kuhn

et al. 2005

The American Journal of Dermatopathology

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“…Given that the two types of tumor cells were intimately admixed, a collision of two distinct tumors or formation of a metastasis of one tumor into the other appeared highly unlikely. In contrast to a simple colonization of SCCs with melanocytes [12], which are cytologically unremarkable and show small nuclei, melanocytes in our case revealed the typical architecture of an aggressive neoplastic proliferation with a malignant, epithelioid cytomorphology and a high mitotic activity. On the other hand, identification of atypical squamoid cells with mitoses, hyperchromatic atypical nuclei, prominent nucleoli, and pronounced dyskeratosis were consistent with the diagnosis of SCC, ruling out pseudocarcinomatous hyperplasia, which has been described as a reactive process in melanomas [11].…”

Section: Introductionmentioning

confidence: 80%

“…Moreover, SMT should not be confused with a reactive colonization of only one malignant proliferation with another cell type, e.g. pseudocarcinomatous hyperplasia in melanoma [11] or colonization of SCC with cytologically unremarkable melanocytes [12]. Noteworthy, a case with two concurrent neoplasms involving different nails of the same hand has been reported [13].…”

Section: Introductionmentioning

confidence: 99%

Squamomelanocytic Tumor of the Nail Unit Metastasizing to a Sentinel Lymph Node: A Dermoscopic and Histologic Investigation

Haenssle¹,

Buhl²,

Holzkamp³

et al. 2012

Dermatology

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“…The problem is further compounded by the presence of pagetoid migration in Paget's disease or in amelanotic superficial spreading melanoma in situ; this is not, however, a feature that typifies porocarcinoma in situ. 149 Those tumors with dermal invasion must be distinguished from squamous cell carcinoma and other forms of malignant eccrine neoplasia. The eccrine porocarcinoma, like the eccrine poroma, is composed of small cuboidal cells manifesting intercellular bridges and eosinophilic cytoplasms with sharply defined cell borders.…”

Section: Differential Diagnosismentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Pigmented eccrine porocarcinoma: a mimic of malignant melanoma

Cited by 35 publications

References 2 publications

Combined High-Grade Basal Cell Carcinoma and Malignant Melanoma of the Skin (???Malignant Basomelanocytic Tumor???)

Combined High-Grade Basal Cell Carcinoma and Malignant Melanoma of the Skin (???Malignant Basomelanocytic Tumor???)

Squamomelanocytic Tumor of the Nail Unit Metastasizing to a Sentinel Lymph Node: A Dermoscopic and Histologic Investigation

Malignant adnexal neoplasms

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