Pigmented renal clear cell carcinoma with melanocytic differentiation

Jun, Lei; Middleton, Lavinia P.; Guo, Xiao Du; Duray, Paul H.; McWilliams, Glen; Linehan, W. Marston; Merino, María J.

doi:10.1053/hupa.2001.22009

Cited by 26 publications

(23 citation statements)

References 12 publications

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“…These tumors were entirely different both histologically and immunohistochemically (no pseudorosettes, no large eosinophilic cells, no small HMB45-positive lymphocyte-like cells) from the t(6;11) associated renal tumors presented herein and in previous studies. Another case report of melanotic CCRCC was published in 2001 by Lei et al [31]. However, besides HMB45 positivity, this tumor displayed characteristic histologic features of CCRCC.…”

Section: Discussionmentioning

confidence: 92%

A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases

et al. 2012

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Section: Discussionmentioning

confidence: 92%

A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases

et al. 2012

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“…There were, however, no described light microscopic or ultrastructural features corresponding to CRCC. Another case report of melaninpigmented clear (conventional) renal cell carcinoma was published in 2001 by Lei et al [26]. The occurrence of a lipochrome pigment is not unique to the PMCRC.…”

Section: Discussionmentioning

confidence: 98%

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Hes

Vaněček

Montiel³

et al. 2005

Virchows Arch

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We present clinical, morphological, immunohistochemical, ultrastructural and molecular genetic features of 20 cases of a peculiar form of chromophobe renal cell carcinoma (CRCC) with morphology differing from that of conventional CRCC. Microscopically, the typical features of the tumors were microcystic arrangement and formation of adenomatous structures. Microcystic areas were composed of smaller eosinophilic and bigger pale cells having cytological appearance typical of conventional CRCC. Cytological features of the adenomatous structures were mostly different from those of conventional CRCC. They had a typical columnar arrangement with nuclei positioned at the base of the glandular structures and a small amount of a deeply eosinophilic cytoplasm often endowed with brush border facing the lumen of the glands. In addition, all the tumors showed a brown pigmentation. The pigmentation was located mostly extracellularly, where it formed pools of heavy deposits. Microscopic calcifications present in all cases formed psammoma bodies or else the calcifications were more extensive and amorphous in shape. Ultrastructurally, the cells showed features characteristic of CRCC: typical cytoplasmic vesicles were 100-700 nm in size and mitochondria had tubulovesicular, lamellar or circular cristae. Some tumor cells contained dark, variously sized electron-dense pigment granules. Neither melanosomes nor membrane-bound neurosecretory granules were seen. Using fluorescence in-situ hybridization probes for chromosomes 1, 2, 6, 10, 13, 17 and 21, the tumors revealed massive loss of tested chromosomes typical for conventional CRCC. Monosomy of chromosomes 1, 2, 6, 10, 13 and 21 was found in 100, 36, 91, 82, 82, 82 and 64% of cases, respectively. None of the cases showed mutation of exons 9, 11, 13 and 17 of the c-kit gene. The important feature of pigmented microcystic chromophobe renal cell carcinoma is a relatively benign biological behavior and the absence of distant metastases and sarcomatoid transformation.

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“…28 In 2001, Lei and colleagues reported an unusual case of melanin-pigmented clear cell RCC with melanocytic differentiation. 29 In their case, upon gross examination, they found a solid yellow and tan tumour measuring 8 × 7 × 6 cm occupying the upper pole of the kidney. Upon light microscopic evaluation, they found abundant black pigment.…”

Section: Discussionmentioning

confidence: 96%

“…Upon light microscopic evaluation, they found abundant black pigment. 29 Moreover, many cases were melanocytic differentiation, which led to RCC.…”

Section: Discussionmentioning

confidence: 99%

Normal black kidney

Yarmohamadi

Rezayat

Memar

et al. 2014

CUAJ

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A black kidney has 3 major differential diagnoses: hemosiderosis, lipofuscin pigment and melanotic renal cell carcinoma. Excluding lipofuscin, the other 2 are accompanied by an abnormal renal function. We report on a 25-year-old man who intended to donate a kidney to his cousin. On the operating room table when we incised the left flank region and exposed the kidney, we found a firm and black kidney so the operation was cancelled due to potential vascular injuries. Days after the incomplete procedure, we reviewed the donor's biochemistry and imaging to reassess his renal function, but the results showed quite normal renal function again. The result of Ham test was also negative. Two weeks later, we began the operation, removed the same left kidney and found that it was in the same conditions as it was before. We took the opportunity to send needle biopsies of the kidney for histopathologic analysis. The analysis showed a melanotic kidney without pathological changes in glomeruli and interstitium and vessels. A black kidney may result in hemosiderin, lipofuscin or melanin deposits in the kidney, which can confirm the diagnosis; however, special tests for underlying disease and renal function should be considered. Some causes of black kidney lead to abnormal function, but our patients's kidney returned to normal.

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Pigmented renal clear cell carcinoma with melanocytic differentiation

Cited by 26 publications

References 12 publications

A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases

A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases

Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation—a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases

Normal black kidney

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