Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis

Bhatnagar, Kaneeka; As, Bawa; Narang,; Kaur, Prabhleen

doi:10.7860/jcdr/2017/28184.10099

Cited by 3 publications

(11 citation statements)

References 11 publications

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“…14 Unfortunately, those are do not undergo surgical excision or other treatments, risk continued joint damage as PVNS is a locally destructive lesion although it is considered to be benign. 15 Confirmation of the diagnosis is accomplished after surgical removal when histopathology testing is able to be performed. Histology reveals hypertrophy of the synovium with irregular protrusions and projections.…”

Section: Discussionmentioning

confidence: 99%

“…Nodules containing hemosiderin pigment, scattered multinucleated giant cells and foamy macrophages are also present. 15 Post-surgical restoration of joint function is accomplished via the rehabilitation process with physical therapy eventually culminating in return to pre-surgical activities like skiing. The initiation of physical therapy at an appropriate time, around 2 weeks post-operative, aligns with established protocols for gradual recovery and restoration of functional capacity.…”

Section: Discussionmentioning

confidence: 99%

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A High-Speed Ski Crash Leading to a Unique Synovial Cause for Knee Pain

Vomer,

York,

Abadin

et al. 2024

MRAJ

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The presented case involves the evaluation, diagnosis, and management of a 20-year-old male high-level skier who presented with persistent right knee pain following a ski crash. The patient reported hitting his right knee against a tree during the accident, resulting in intermittent swelling and a sensation of a mass within the knee. Despite some initial improvement in the sensation, the pain then became persistent and worsened by activity. Physical examination revealed limited symptoms during gait and functional movements, as well as restricted medial joint line tenderness and a mildly positive McMurray's test on the right knee. Magnetic resonance imaging findings prompted an orthopedic referral, leading to a right knee arthroscopy. The procedure involved resection of nodular synovitis and a diffuse synovectomy, with pathology confirming pigmented villonodular synovitis (PVNS). Despite post-operative complications, including methicillin-resistant Staphylococcus aureus bacteremia, ultimately, the patient's recovery was successful with the gradual restoration of pain-free range of motion through physical therapy. Follow-up assessments and magnetic resonance imaging scans indicated sustained improvement and no signs of pigmented villonodular synovitis recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A High-Speed Ski Crash Leading to a Unique Synovial Cause for Knee Pain

Vomer,

York,

Abadin

et al. 2024

MRAJ

View full text Add to dashboard Cite

show abstract

“…[4][5][6] One such case report of involvement of the temporomandibular joint by PVNS has been reported by Lu et al 6 PVNS is known to be affecting both genders and its average age of diagnosis is between 30-40 years. 2,6,7 One of the large retrospective multicentre studies of 237 cases of PVNS published by Xie et al 1 reports knee and hip as the commonest sites of occurrence of PVNS.…”

Section: Discussionmentioning

confidence: 99%

“…The present case is unique for the rarity of presentation wherein all the bones of the right wrist except pisiform bone and 2 nd , 3 rd , 4 th metacarpal bones were involved in the disease process. Such a rare occurrence of involvement of PVNS locally in the wrist bone along with involvement of metacarpal bones has not been reported in the search literature except for Luo et al 9 and Carpentiro et al 11 There are very few case reports which describe the diagnosis of PVNS on FNAC i.e., Lu et al, Bhatnagar et al, Luo et al and Choi et al 6,7,9,12 The FNAC of PVNS usually is brown coloured turbid aspirate. The present case which underwent FNAC at three sites yielded brown colour turbid fluidy material.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Giri Goswami,

Bhake,

Khan

et al. 2023

F1000Res

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Background Pigmented Villonodular Synovitis (PVNS) is a rare disease of osteoskeletal tissue. Cytodiagnosis of PVNS on fine needle aspiration (FNA) smears is therefore rarely reported. The PVNS usually affects the larger joints. The involvement of the smaller joints and bones are uncommon. Case presentation The reported case is one such rarity wherein the diagnosis of PVNS was carried out on the FNAC. The case showed the involvement of all carpal bones except for the pisiform. The 2nd- 5th metacarpal bases were also found to be involved in the disease process. The presence of sheets of synoviocytes with brown altered hue to the cytoplasm along with multinucleate giant cells and pigmented macrophages were characteristically present in the smears of FNA. The diagnosis was confirmed on the tissue biopsy. The present case is reported for its unusual multiosteotic involvement of wrist joint bones and the metacarpal bones simultaneously with radiological evidence. The cytomorphology of the lesion in the present case were noteworthy as a learning experience in reporting of PVNS of wrist joint on FNA smears.

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“…TNF-α stimulates the production of MMPs, which can lead to cartilage and bone destruction in PVNS (O'Keefe et al, 1998). In PVNS, the presence of macrophage, histiocyte, and plasma cell infiltration stimulates an inflammatory response (Bhatnagar et al, 2017).…”

Section: Aliasesmentioning

confidence: 99%

Exploration of comorbidity mechanisms and potential therapeutic targets of rheumatoid arthritis and pigmented villonodular synovitis using machine learning and bioinformatics analysis

Heng

Li²,

Su³

et al. 2023

Front. Genet.

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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease. Pigmented villonodular synovitis (PVNS) is a tenosynovial giant cell tumor that can involve joints. The mechanisms of co-morbidity between the two diseases have not been thoroughly explored. Therefore, this study focused on investigating the functions, immunological differences, and potential therapeutic targets of common genes between RA and PVNS.Methods: Through the dataset GSE3698 obtained from the Gene Expression Omnibus (GEO) database, the differentially expressed genes (DEGs) were screened by R software, and weighted gene coexpression network analysis (WGCNA) was performed to discover the modules most relevant to the clinical features. The common genes between the two diseases were identified. The molecular functions and biological processes of the common genes were analyzed. The protein-protein interaction (PPI) network was constructed using the STRING database, and the results were visualized in Cytoscape software. Two machine learning algorithms, least absolute shrinkage and selection operator (LASSO) logistic regression and random forest (RF) were utilized to identify hub genes and predict the diagnostic efficiency of hub genes as well as the correlation between immune infiltrating cells.Results: We obtained a total of 107 DEGs, a module (containing 250 genes) with the highest correlation with clinical characteristics, and 36 common genes after taking the intersection. Moreover, using two machine learning algorithms, we identified three hub genes (PLIN, PPAP2A, and TYROBP) between RA and PVNS and demonstrated good diagnostic performance using ROC curve and nomogram plots. Single sample Gene Set Enrichment Analysis (ssGSEA) was used to analyze the biological functions in which three genes were mostly engaged. Finally, three hub genes showed a substantial association with 28 immune infiltrating cells.Conclusion: PLIN, PPAP2A, and TYROBP may influence RA and PVNS by modulating immunity and contribute to the diagnosis and therapy of the two diseases.

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Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis

Cited by 3 publications

References 11 publications

A High-Speed Ski Crash Leading to a Unique Synovial Cause for Knee Pain

A High-Speed Ski Crash Leading to a Unique Synovial Cause for Knee Pain

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Exploration of comorbidity mechanisms and potential therapeutic targets of rheumatoid arthritis and pigmented villonodular synovitis using machine learning and bioinformatics analysis

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