Pilot Clinical Study of an Endoscopic, Removable Duodenal-Jejunal Bypass Liner for the Treatment of Type 2 Diabetes

Rodríguez, Leonardo; Reyes, Eliana; Fagalde, Pilar; Oltra, Maria Soledad; Saba, Jorge; Aylwin, Carmen Gloria; Prieto, Carolina; Ramos, Almino Cardoso; Galvão, Manoel; Gersin, Keith S.; Sorli, Christopher H.

doi:10.1089/dia.2009.0063

Cited by 123 publications

(73 citation statements)

References 21 publications

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“…FIGURE 2 Previously studies with obese patients that used the duodenojejunal bypass liner (DJBL) demonstrated a significant weight loss. In addition, an improvement in the control of T2DM was observed, which was statistically greater than that of the group treated with a lowcalorie diet [26][27][28][29][30][31][32][33].…”

Section: Metabolic Improvements With Duodeno Jejunal Bypass Linermentioning

confidence: 75%

Endoscopic Treatment of Metabolic Syndrome

Moura¹,

Orso²,

Martins³

et al. 2012

Lipoproteins - Role in Health and Diseases

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Section: Metabolic Improvements With Duodeno Jejunal Bypass Linermentioning

confidence: 75%

Endoscopic Treatment of Metabolic Syndrome

Moura¹,

Orso²,

Martins³

et al. 2012

Lipoproteins - Role in Health and Diseases

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“…In a prospective randomized trial by Rodriguez et al, lower mean fasting glucose and postprandial AUC of glucose were found in the endoluminal sleeve group compared with the group in which sham endoscopy was performed. However, the decrease in HbA1C was not significantly different between the two groups at either 12 or 24 weeks [76]. In a randomized study of endoluminal sleeve versus diet control, Schouten et al found that diabetes improved in 87.5% of the patients over 12 weeks, with one patient not needing diabetic medications at 12 weeks of follow-up.…”

Section: Effect Of Novel Bariatric Surgical Techniques On Diabetesmentioning

confidence: 98%

Diabetic and bariatric surgery: A review of the recent trends

Rao

Kini

2011

Surg Endosc

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RYGB and biliopancreatic diversion (BPD) are effective surgical options for diabetes in the long term (>5 yrs). The efficacy of sleeve gastrectomy on diabetes in the long term is not yet known. Gastrointestinal procedures for non morbidly obese and non obese patients have shown great promise as surgical optional for diabetes, though their efficacy and safety in the long term are unknown. Novel endoscopic techniques and TANTALUS have shown some promise in resolving diabetes in obese patients. Bariatric surgery is very effective is resolving adolescent diabetes.

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“…Obesity is the consequence of the imbalance between energy intake and expenditure. To manage obesity, several approaches have been taken including diet modifi cation, exercise regiment, bariatric surgery ( 87 ), and intestinal sleeve implantation ( 88 ). Although diet and exercise are the most widely accepted recommendation to combat obesity, many people still struggle to reduce their body weight with this approach.…”

Section: Cars Imaging Of Intestinal Lipid Absorptionmentioning

confidence: 99%

Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy

Yue

Cheng

2010

Journal of Lipid Research

148

130

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Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive techniques and population measurements. The molecular profi les of the lipid-rich structures are evaluated by measurements of total lipid extracts with liquid or gas chromatography coupled to mass spectrometry ( 8 ). This approach is inexact because it measures lipid molecules from areas other than the structures of interest. Furthermore, spatial information, which is critical to understanding the function of lipids ( 9 ), is inaccessible with the bulk measurement techniques. To visualize the lipid-rich structures, fl uorescently tagged lipid molecules, which intercalate with the lipidrich structures, are used ( 10, 11 ). Nevertheless, the use of the fl uorescent lipid molecules to label lipid-rich structures is problematic for several reasons. First, to facilitate the transport of the fl uorescent lipid molecules into cells, cell fi xation procedures are often performed ( 12 ). This procedure prevents monitoring the dynamic responses of lipid-rich structures to stimuli or the disease processes. Second, labeling effi ciency is highly dependent on the type of fl uorescent lipid molecules ( 12 ), thus posing a signifi cant problem to the quantitation of lipid-rich structures. Third, the intercalation of fl uorescent lipid molecules can lead to changes in the properties of lipidrich structures. For instance, incorporation of fl uorescent lipid molecules into the cell membrane can induce membrane phase separation and membrane microdomain formation, which can perturb critical cellular processes including signal transduction and endocytosis ( 13 ).As an alternative to fl uorescence, signals from molecular vibration provide an attractive means for label-free chemical imaging. In particular, Raman scattering has been widely used for spectroscopic study of biomolecules ( 14 ). The Raman-scattered photons exhibit frequency Abstract Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive techniques, population measurements, or nonspecifi c labeling. Such diffi culties can be circumvented by a label-free imaging technique known as coherent anti-Stokes Raman (CARS) microscopy, which is capable of chemically selective, highly sensitive, and high-speed imaging of lipid-rich structures with submicron three-dimensional spatial resolution. We review the broad applications of CARS microscopy to studies of lipid biology in cell cultures, tissue biopsies, and model organisms. Recent technical advances, limitations of the technique, and perspectives are discussed. Lipids play a critical role in human health and diseases. Phospholipids, glycolipids, and sterol lipids are the major components of the cell membrane ( 1 ). Sphingolipids constitute up to 80% of the myelin sheaths, which are the membranous structures that wrap around the axons for insulation and for proper propagation of electrical impulses ( 2 ). Glycerolipids or triglycerides serve as the cytoplasmic energy depots ( 3 ). Bioactive lip...

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Pilot Clinical Study of an Endoscopic, Removable Duodenal-Jejunal Bypass Liner for the Treatment of Type 2 Diabetes

Abstract: The DJBL rapidly normalized glycemic control in obese T2DM subjects, a promising development in the search for novel therapies less invasive than bariatric surgery.

Cited by 123 publications

References 21 publications

Endoscopic Treatment of Metabolic Syndrome

Endoscopic Treatment of Metabolic Syndrome

Diabetic and bariatric surgery: A review of the recent trends

Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy

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