Pilot Plants for Industrial Nanoparticle Production by Flame Spray                    Pyrolysis

Wegner, Karsten; Schimmöller, B.; Thiébaut, Bénédicte; Fernández, C.; Rao, Tata N.

doi:10.14356/kona.2011025

Cited by 82 publications

(67 citation statements)

References 35 publications

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“…At the nanoscale, inorganic metal oxides are potentially highly efficient agents for binding ions such as arsenic or some pollutants and today's challenge is the translation of these achievements into an industrial production environment which requires scale-up to a continuous and safe nanoparticle 4 manufacturing process as reported elsewhere [17][18][19]. By tailoring the composition of the metal oxides, selective adsorption of different ions can be introduced.…”

Section: Introductionmentioning

confidence: 99%

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Morillo

Uheida

Pérez

et al. 2015

Journal of Colloid and Interface Science

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In the present work, superparamagnetic iron oxide nanoparticles (SPION) surface-coated with 3-mercaptopropanoic acid (3-MPA) were prepared and their feasibility for the removal of arsenate from dilute aqueous solutions was demonstrated. The synthesized 3-MPA-coated SPION was characterized using transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Fourier transform infra-red spectrometry (FTIR). Separation efficiency of the coated nanoparticles and the equilibrium isotherm of arsenate adsorption were investigated. The obtained results reveal the arsenate adsorption to be highly pH-dependent, and the maximum adsorption was attained in less than 60 minutes. The resulting increase of 3-MPA-coated SPION adsorption capacity to twice the adsorption capacity of SPION alone under the same conditions is attributed to the increase of active adsorption sites. An adsorption reaction is proposed. On the other hand, efficient recovery of arsenate from the loaded nanoparticles was achieved using nitric acid (HNO 3 ) solution, which also provides a concentration over the original arsenate solution. HIGHLIGHTS• Feasibility of using SPION modified with 3MPA for the removal of As(V).• The adsorbent system results in an effective sorption for selective As(V) removal.• The adsorption capacity for As(V) is higher comparing with other adsorbent systems.• Adsorption mechanism has been proposed as the most suitable considering the results.

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Section: Introductionmentioning

confidence: 99%

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Morillo

Uheida

Pérez

et al. 2015

Journal of Colloid and Interface Science

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“…Finally, the process has been shown to be scalable and products are already available commercially (Nanocerox). 14 The NPs synthesized here were shown to be between 7.9 and 11.7 nm in diameter (Table 1) with anatase particles being smaller than rutile particles, and the presence of the gadolinium dopant was confirmed by EDX ( Figure 1C). The gadolinium-doped NPs prepared by FSP were subsequently confirmed to act as radiosensitizers in cell culture, showing a large reduction in both clonogenic survival ( Figure 2) and cell proliferation (Figure 3).…”

Section: Np Synthesis and Characterizationmentioning

confidence: 63%

Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle

Morrison¹,

Rybak-Smith²,

Thompson

et al. 2017

IJN

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The aim of this study was to develop a manufacturing protocol for large-scale production of doped titania radiosensitizing nanoparticles (NPs) to establish their activity under hypoxia and to produce a multimodal radiosensitizing embolic particle for cancer treatment. We have previously shown that radiosensitizing NPs can be synthesized from titania doped with rare earth elements, especially gadolinium. To translate this technology to the clinic, a crucial step is to find a suitable, scalable, high-throughput method. Herein, we have described the use of flame spray pyrolysis (FSP) to generate NPs from titanium and gadolinium precursors to produce titania NPs doped with 5 at% gadolinium. The NPs were fully characterized, and their capacity to act as radiosensitizers was confirmed by clonogenic assays. The integrity of the NPs in vitro was also ascertained due to the potentially adverse effects of free gadolinium in the body. The activity of the NPs was then studied under hypoxia since this is often a barrier to effective radiotherapy. In vitro radiosensitization experiments were performed with both the hypoxia mimetics deferoxamine and cobalt chloride and also under true hypoxia (oxygen concentration of 0.2%). It was shown that the radiosensitizing NPs were able to cause a significant increase in cell death even after irradiation under hypoxic conditions such as those found in tumors. Subsequently, the synthesized NPs were used to modify polystyrene embolization microparticles. The NPs were sintered to the surface of the microparticles by heating at 230°C for 15 minutes. This resulted in a good coverage of the surface and to generate embolization particles that were shown to be radiosensitizing. Such multimodal particles could therefore result in occlusion of the tumor blood vessels in conjunction with localized reactive oxygen species generation, even under hypoxic conditions such as those found in the center of tumors.

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“…The precursor should be fed into the reactor at low pulsation rates as sprays are sensitive to oscillations in the liquid fuel supply which can affect nanoparticle growth conditions. When the flow rate of the precursor is increased, the particle diameter also increases but decreases when the dispersion gas flow rate is increased as a result of rapid mixing reactants and oxidizers [29].…”

Section: Spray Pyrolysismentioning

confidence: 99%

Synthetic Methods for Titanium Dioxide Nanoparticles: A Review

Nyamukamba¹,

Okoh²,

Mungondori³

et al. 2018

Titanium Dioxide - Material for a Sustainable Environment

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Titanium dioxide (TiO 2 ) semiconductor nanoparticles are one kind of important and promising photocatalysts in photocatalysis because of their unique optical and electronic properties. Their properties, which are determined by the preparation method, are very crucial in photocatalysis. In this chapter, an overview was carried out on the different methods that are used or have been used to prepare titanium dioxide nanoparticles. There are various methods that can be used to synthesize TiO 2 and the most commonly used methods include sol-gel process, chemical vapor deposition (CVD) and hydrothermal method among others. This review will focus on selected preparation methods of titanium dioxide photocatalyst.

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Pilot Plants for Industrial Nanoparticle Production by Flame Spray Pyrolysis

Cited by 82 publications

References 35 publications

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle

Synthetic Methods for Titanium Dioxide Nanoparticles: A Review

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