Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

Crandall, Jill P.; Oram, V; Trandafirescu, Georgeta G.; Reid, Migdalia; Kishore, Preeti; Hawkins, Meredith; Cohen, Hillel W.; Barzilai, Nir

doi:10.1093/gerona/glr235

Cited by 261 publications

(237 citation statements)

References 34 publications

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“…Although these trials have used different subject groups (e.g., type 2 diabetics or older adults with glucose intolerance) and different resveratrol doses, they have indicated that resveratrol may improve insulin sensitivity. [16][17][18] Moreover, other studies have shown that resveratrol can treat organic injuries to tissues including the retina and liver by resisting oxidative stress. 19,20 To investigate the effects of resveratrol in diabetes-induced ED, we used a model of STZ-induced diabetes in rats.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Yao¹,

Wan²,

Qiu³

et al. 2013

Asian J Androl

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The high incidence of erectile dysfunction (ED) in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin (65 mg kg 21 )-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), p53 and forkhead transcription factor O 3a (FOXO3a), superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was downregulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SIRT1 and restored erectile function. In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Yao¹,

Wan²,

Qiu³

et al. 2013

Asian J Androl

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“…Our moderators were unable to describe the origin of this heterogeneity, perhaps because minor experimental factors may make animals more or less sensitive to resveratrol depending on their condition. Resveratrol has shown some indication of positive effects on insulin and metabolic function in humans [17,18]. However, at a time when human trials testing for health benefits from resveratrol are in their early days, we believe it is inappropriate for resveratrol to be marketed as a lifeextending health supplement when our analysis of the current knowledge provides such varied results.…”

Section: Discussionmentioning

confidence: 99%

The effect of resveratrol on longevity across species: a meta-analysis

2012

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Resveratrol has shown evidence of decreasing cancer incidence, heart disease, metabolic syndrome and neural degeneration in animal studies. However, the effects on longevity are mixed. We aimed to quantify the current knowledge of life extension from resveratrol. We used meta-analytic techniques to assess the effect resveratrol has on survival, using data from 19 published papers, including six species: yeast, nematodes, mice, fruitflies, Mexican fruitflies and turquoise killifish. Overall, our results indicate that resveratrol acts as a life-extending agent. The effect is most potent in yeast and nematodes, with diminished reliability in most higher-order species. Turquoise killifish were especially sensitive to life-extending effects of resveratrol but showed much variation. Much of the considerable heterogeneity in our analysis was owing to unexplained variation between studies. In summary, we can report that few species conclusively show life extension in response to resveratrol. As such, we question the practice of the substance being marketed as a life-extending health supplement for humans.

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“…Ten patients, aged 60-80 with impaired glucose tolerance, were treated with resveratrol for 4 wk. Fasting glucose was unchanged, but postprandial glucose levels were lowered without an increase in insulin production, indicating improved insulin sensitivity [59]. Notably, the doses in the Sirtris trials (2.5-5 g/day) were in the range where gastrointestinal side effects have been reported [30], and the doses in the Crandall trial (1-2 g/day) were very close, meaning that a thorough evaluation of both the efficacy and the side effects is needed to determine the potential of resveratrol as an anti-diabetic in humans.…”

Section: Obesity and Diabetesmentioning

confidence: 96%

“…In early 2008, Sirtris Pharmaceuticals announced that their proprietary formulation of resveratrol, SRT501, had improved glucose tolerance in type II diabetics in a Phase 1b clinical trial, in the absence of serious adverse events [58]. In mid-2010, Crandall et al presented preliminary findings supporting an insulinsensitizing effect of resveratrol in humans [59]. Ten patients, aged 60-80 with impaired glucose tolerance, were treated with resveratrol for 4 wk.…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Resveratrol and health – A comprehensive review of human clinical trials

Smoliga

Baur

Hausenblas

2011

Molecular Nutrition Food Res

502

308

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In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well-tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.

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Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

Abstract: At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.

Cited by 261 publications

References 34 publications

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

The effect of resveratrol on longevity across species: a meta-analysis

Resveratrol and health – A comprehensive review of human clinical trials

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