To observe the clinical effect of preoperative oral carbohydrate(POC) combined with individualized medication (oral hypoglycemic agents or/and insulin) that has been used steadily in patients with type 2 diabetes mellitus. Patients undergoing elective laparoscopic non-gastrointestinal surgery were studied. Thirty type 2 diabetic patients with good glycemic control were selected as diabetic group (Group D) and 31 non-diabetic patients were recruited as control group(Group C). In both groups, 400mL carbohydrate drink was taken orally 2 hours before anesthesia. Anti-diabetes medication was given individually in the diabetic group(Group D) according to their daily use. Blood glucose was detected and recorded at the time of fasting (T0), 1 hour after POC (T1), before anesthesia(T2), 15min after pneumoperitoneum(T3), 30min after pneumoperitoneum (T4), and in recovery room (T5) for both groups. Ultrasound of gastric antrum was assessed and semi-quantification of gastric contents(Perlas A scale) was performed. Perioperative hunger, nausea, vomiting and postoperative exhaust time were also recorded. There was no statistically significant difference between two groups above in blood glucose at T0 and T5(P> 0.05);at T1,T2,T3 and T4, compared with Group C, patients in Group D had significantly higher blood glucose (P<0.05), but within 250mg/dl(13.9mmol/L). No additional hypoglycemic intervention implemented; no symptoms of discomfort was reported as well. For gastric antrum Perlas A grading before general anesthesia, there was no statistically significant difference in the scores between the two groups (P> 0.05), and no reflux aspiration was observed in both groups. There was no statistically significant difference in perioperative hunger, nausea and vomiting, and postoperative exhaust time between the two groups (P> 0.05). Preoperative oral carbohydrate (POC) can be applied to well glucose-controlled type 2 diabetic patients.