2016
DOI: 10.1016/j.ijcard.2016.03.181
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Pin1 in cardiovascular dysfunction: A potential double-edge role

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Cited by 13 publications
(4 citation statements)
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“…Furthermore, although the eNOS protein expression in the high glucose-cultured HUVECs was upregualted more obviously by vitamin D than by Juglone, the NO production showed little difference between the two active drugs. The disproportionate change of eNOS protein expression and NO production by Juglone may be ascribed to higher NO bioavailability caused by isomerization of the phosphorylated Ser-116 residue in eNOS by Pin1 [ 9 ] or reduced iNOS degradation through the calpain pathway [ 27 , 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, although the eNOS protein expression in the high glucose-cultured HUVECs was upregualted more obviously by vitamin D than by Juglone, the NO production showed little difference between the two active drugs. The disproportionate change of eNOS protein expression and NO production by Juglone may be ascribed to higher NO bioavailability caused by isomerization of the phosphorylated Ser-116 residue in eNOS by Pin1 [ 9 ] or reduced iNOS degradation through the calpain pathway [ 27 , 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the results obtained with juglone are not necessarily due to Pin1 inhibition and may account for the discrepant results described above. Wang et al advocated that the involvement of iNOS be investigated because Pin1 regulates iNOS by promoting both its induction and its degradation [ 98 ]. Despite the discrepant results, it seems certain that Pin1 is involved in NO production in the aorta and we anticipate that elucidating of precise mechanism(s) will contribute to developing treatments for hypertension.…”
Section: The Role Of Pin1 In Hypertensionmentioning
confidence: 99%
“…Pin1 is the only known isomerase that regulates cis-trans structural transition and phosphorylation of many signaling proteins (pThr/pSer-Pro motifs) [18,19]. Previously, it is well known that amyloid-β deposition and tau aggregation are two major molecular pathologies in cerebral disorders especially AD, but Pin1 regulates processing of amyloid precursor protein and reduces amyloid-β and tau aggregates [19][20][21].…”
Section: A New Pin1-based Hypothesis For Cerebrovascular Pathology and Ischemia-related Neurological Disordersmentioning
confidence: 99%