Pineal anlage tumor: a case report and review of the literature

Cambruzzi, Eduardo; Medeiros, Mateus Scarabelot; Silva, José Nathan Andrade Muller da; Nascimento, Gabriella Bezerra Cortês; Zandoná, Natália Brandelli; Kus, Willian Pegoraro

doi:10.1007/s00381-021-05441-z

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Furthermore, patient stratification according to tumor molecular characteristics may show that optimal treatment strategies differ by molecular subgroup, but due to the lack of data this remains to be seen. As we sought to include tumors classified by the World Health Organization in the initial screening for this review, relatively rare entities, such as pineal anlage tumors [ 73 , 74 ], were not included. It is also possible that with contemporary molecular neuropathologic techniques, some of the patients included in the current study, especially older adults reported in studies prior to 2007, would have had their tumors reclassified [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Nandoliya,

Sadagopan,

Thirunavu

et al. 2023

Cancers

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Most of the literature on pineoblastoma consists of case reports and single-institution series. The goal of this systematic review and individual patient data (IPD) analysis was to summarize the existing literature, identify factors associated with overall survival (OS), and provide a contemporary update on prognosis for patients with pineoblastoma. Forty-four studies were identified with 298 patients having IPD. Kaplan–Meier analyses were used to report survival outcomes based on age, tumor metastases, extent of resection (EOR), adjuvant therapy, and publication year. Cox regression was performed to identify independent predictors of time to mortality. Multivariable recursive partitioning analysis was used to identify the most important subgroups associated with mortality. Patients were classified based on publication year before and after the last systematic review on this topic (pre-2012 and 2012 onwards) and compared using univariate and multivariable analyses. This study demonstrates that EOR less-than-gross total resection, metastatic presentation, adjuvant chemotherapy without radiation, and tumor presentation in children less than three years old are associated with poorer prognosis. Since 2012, the 5-year actuarial OS has improved from 32.8% to 56.1%, which remained significant even after accounting for EOR, age, and adjuvant therapy. Pineoblastoma remains a severe rare disease, but survival outcomes are improving.

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Section: Discussionmentioning

confidence: 99%

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Nandoliya,

Sadagopan,

Thirunavu

et al. 2023

Cancers

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Pineal anlage tumor: a case report and the literature review

Ying

Yang

et al. 2022

Childs Nerv Syst

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Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment

Obrecht-Sturm,

Pfaff,

Mynarek

et al. 2024

J Neurooncol

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Purpose To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT). Methods Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases. Results Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2 ± 7.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection/biopsy: 9, extent of resection unknown: 2). 15/20 patients were alive at last follow-up. Median follow-up for 10/15 surviving patients with available follow-up and treatment data was 2.4 years (0.3–6.5). Relapse was reported for 3 patients within 0.8 years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2 ± 12.7% and 49.2 ± 18.2%, respectively. All 4 patients who received intensive chemotherapy including high-dose chemotherapy combined with radiotherapy (2 focal, 2 craniospinal [CSI]) had no recurrence. Focal radiotherapy- and CSI-free survival rates in 13 evaluable patients were 46.2% (6/13) and 61.5% (8/13), respectively. Conclusion PAT is an aggressive disease mostly affecting young children. Therefore, adjuvant therapy using intensive chemotherapy and considering radiotherapy appears to comprise an appropriate treatment strategy. Reporting further cases is crucial to evaluate distinct treatment strategies.

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Pineal anlage tumor: a case report and review of the literature

Cited by 3 publications

References 11 publications

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time

Pineal anlage tumor: a case report and the literature review

Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment

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