Pinguecula and Diabetes Mellitus

Mimura, Tatsuya; Obata, Hiroto; Usui, Tomohiro; Mori, Mikiro; Yamagami, Satoru; Funatsu, Hideharu; Noma, Hidetaka; Amano, Shiro

doi:10.1097/ico.0b013e3182254170

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…It follows that pinguecula protrusion may affect tear film stability and therefore TBUT, but we also found that tear film production improved postoperatively. This finding is supported by evidence in the literature of lower tear osmolarity after pterygium excision surgery [14]. Pinguecula and pterygium may influence aqueous tear production via friction against the tarsus causing local inflammation and decreasing accessory lacrimal gland secretion.…”

Section: Discussionsupporting

confidence: 71%

The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue

Jeong

Rand

Kwon

et al. 2019

Journal of Ophthalmology

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Purpose. To evaluate the association between pinguecula excision and subsequent improvement in dry eye syndrome. Methods. We included 30 consecutive patients with primary nasal pinguecula and dry eye symptoms undergoing ocular surgery for the first time. Criteria for pinguecula excision surgery were nasal location, yellowish color, and protrusion of conjunctiva at least 2 times thicker than adjacent normal conjunctiva as measured by anterior segment optical coherence tomography. Our primary outcomes were 3-month postoperative changes in tear film breakup time (TBUT), Schirmer test, and a dry eye symptom score. Results. 30 eyes from 30 different patients (12 men and 18 women) underwent pinguecula excision and conjunctival autografting using fibrin glue. The mean age was 42.5 ± 8.35 (range 28–63) years. The preoperative protrusion ratio of pinguecula was 2.33 ± 0.28 (range 2.00–2.90). Mean preoperative TBUT, Schirmer test, and dry eye symptom scores were 5.10 ± 1.27 seconds, 6.07 ± 2.27 mm, and 2.80 ± 0.76 points. Mean postoperative 3-month TBUT, Schirmer test, and dry eye symptom scores were 7.80 ± 1.13 seconds, 7.27 ± 2.02 mm, and 0.30 ± 0.47 points, respectively. The median pre- and postoperative changes were found to be statistically significant by Wilcoxon signed-rank tests for TBUT, Schirmer test score, and dry eye symptom score. Conclusion. Surgical excision of pinguecula and conjunctival autograft using fibrin glue is an effective and safe method to improve symptoms of dry eye syndrome.

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Section: Discussionsupporting

confidence: 71%

The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue

Jeong

Rand

Kwon

et al. 2019

Journal of Ophthalmology

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“…None of the population-based studies on the prevalence of pinguecula that included DM in the assessment found a relationship between the two [ 3 , 4 , 15 ]. However, results from the hospital-based study by Mimura et al [ 13 ] suggested that DM may be associated with the development of pinguecula, possibly due to deposition of AGEs, diabetic microvascular damage of conjunctival blood vessels, and diabetes-related eye dryness. We could not find a significant association between diabetes and the presence of pinguecula, nor between the severity of pinguecula and diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Pinguecula was diagnosed when present in either eye. The severity of pinguecula was graded according to a scheme based on slit lamp examination findings ( Table 1 ) [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

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The Relationship between Pinguecula and Diabetes Mellitus: A Comparative Cross‐Sectional Study

Jammal

Abu‐Ameerh

Hiasat

et al. 2023

Journal of Ophthalmology

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Purpose. To assess the relationship between diabetes mellitus (DM) and the presence of pinguecula and to identify other risk factors associated with pinguecula in patients attending the eye clinic at two tertiary university hospitals in Jordan. Methods. This was a comparative cross-sectional hospital-based study of 241 consecutive patients (122 patients with DM and 119 patients with no diabetes). All patients underwent complete ophthalmic examination, and data were collected regarding age, sex, occupational activity, presence and grade of pinguecula, glycosylated hemoglobin (HbA1c), and presence of diabetic retinopathy. Results. The mean (standard deviation, SD) ages of the DM and non-DM groups were 59.5 (10.8) years and 59.0 (11.6) years ( p -value = 0.729), respectively. There was no significant difference in the prevalence of pinguecula between the diabetic and nondiabetic groups (66.4% vs. 66.5%, p = 0.998 ). Multivariate logistic regression analysis revealed that only outdoor occupational activity (OR = 5.16, 95% CI: 1.98–13.44, p = 0.001 ) was associated with increased prevalence of pinguecula. DM was not significantly associated with pinguecula (OR = 0.96, 95% confidence interval (CI): 0.55–1.67, p = 0.873 ). Neither age nor sex were significantly associated with pinguecula ( p -value = 0.808, p -value = 0.390), respectively. Conclusion. DM was not significantly associated with the development of pinguecula in this Jordanian population. The prevalence of pinguecula was significantly associated with an outdoor occupational activity.

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“…Pterygium is a multifactorial condition that is mainly associated with aging and exposure to UVR. Because diabetes accelerates the aging process, it may contribute to the development of diseases typical of aging and that ocular aging may lead to the progression of pterygium (13).…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of pterygium patients with type 2 diabetes mellitus

Eroğul¹

2020

Beyoglu Eye J

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The aim of this study was to histopathologically compare patients with and without diabetes mellitus who underwent pterygium excision. Methods: In this retrospective case-control study, 60 patients with a history of pterygium excision were divided into 2 groups: those with DM and those without DM. Histopathological findings (squamous metaplasia, dysplasia, inflammation, fibrinoid changes, and vascularization) were compared. Results: The mean age of the 60 patients (females, 54.5%) included in the study was 58.6±12.8 years. The mean age was 53.7±13.7 years in the patients with DM and 63.6±9.6 years in the patients without DM. There were no significant differences in the excised pterygium tissues in terms of squamous metaplasia, dysplasia, fibrinoid changes, inflammation, or vascularization. Conclusion:There was no histopathological difference in the pterygium tissue in patients with DM.

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Pinguecula and Diabetes Mellitus

Abstract: This is the first assessment of the relationship between pinguecula and diabetes mellitus. Our results suggest that diabetes mellitus may be a factor associated with the development of pinguecula.

Cited by 7 publications

References 28 publications

The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue

The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue

The Relationship between Pinguecula and Diabetes Mellitus: A Comparative Cross‐Sectional Study

Histopathological evaluation of pterygium patients with type 2 diabetes mellitus

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