Pinitol from Soybeans Reduces Postprandial Blood Glucose in Patients with Type 2 Diabetes Mellitus

Abstract

The effect of 3-O-methyl-D-chiro-inositol (D-pinitol), purified from soybean, on the postprandial blood glucose response in patients with type 2 diabetes mellitus was examined. Fifteen Korean subjects with type 2 diabetes mellitus (seven men, eight women; 60.3 +/- 3.1 years old) ingested cooked white rice containing 50 g of available carbohydrate with or without prior ingestion of soy pinitol. Pinitol was given either as a 1.2 g dose at 0, 60, 120, or 180 minutes prior to rice ingestion, or as a 0.6 g dose at 60 minutes prior to rice ingestion. Capillary blood glucose levels were monitored for 4 hours after rice consumption. The ingestion of 1.2 g of pinitol 60 minutes prior to rice consumption controlled postprandial capillary blood glucose most effectively, significantly diminishing the postprandial increase in plasma glucose levels measured at 90 and 120 minutes after rice consumption (P < .05). The incremental area under the plasma glucose response curve for subjects who consumed both pinitol and rice was significantly lower than that for subjects who consumed only rice (P < .05), but pinitol had no apparent effect on postprandial insulin levels. Therefore, soybean-derived pinitol may be useful in controlling postprandial increases in blood glucose in patients with type 2 diabetes.

Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

“…for 20 days (15). In human subjects with type 2 diabetes mellitus, when administered at 1.2 g/d to examine the postprandial blood glucose response, pinitol was found to be well tolerated (51). Thus, these reports suggest that pinitol is quite safe compound.…”

Potential of the Common Ice Plant,Mesembryanthemum crystallinumas a New High-Functional Food as Evaluated by Polyol Accumulation

“…Narayanan et al (1987) showed that administration of pinitol decreased plasma glucose in normal and diabetic albino mice, and Kang et al (2006) suggested that soybean-derived pinitol was useful in controlling the increase in blood glucose in type 2 diabetic patients who were poorly controlled with hypoglycemic drugs, such as sulfonylurea, metformin and/or insulin. Myo-inositol has been implicated in a variety of cellular processes including growth regulation, membrane biogenesis, signal transduction, ion channel physiology, and membrane dynamics (Loewus and Murthy, 2000).…”

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

“…[150] However, another study has reported that postprandial blood glucose is reduced in patients with type 2 diabetes when given pinitol 60 minutes prior to a meal. [151] Patients with type 2 diabetes that was poorly controlled by hypoglycaemic drugs were treated with pinitol at a dosage of 20mg kg -1 day -1 for twelve weeks after which they had decreased fasting and postprandial glucose levels but unchanged lipid profiles and adipocytokine levels. [152] A 6g dose of pinitol, when coadministered with glucose, reduced serum glucose and insulin at 45 and 60 minutes compared with controls.…”