Pinniped Communication

Eaton, Taryn

doi:10.1007/978-3-319-55065-7_935

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Changing cutoff levels must be done carefully so that false positive screens are maintained at reasonable levels. To keep cutoff levels relatively stable, some programs have recently refined their methods to exclude certain specimens with characteristics known to be associated with higher IRT values (e.g., those that were collected within 48 h of a transfusion and those collected from very low birth weight infants) from the calculation of the percentile used for the cutoff [ 14 ]. Because many states that utilize a floating cutoff in this study are the same states that have the lowest IRT cutoffs, it is hard to be confident that a floating cutoff by itself is driving this finding.…”

Section: Discussionmentioning

confidence: 99%

Missed Cystic Fibrosis Newborn Screening Cases due to Immunoreactive Trypsinogen Levels below Program Cutoffs: A National Survey of Risk Factors

Kharrazi

Sacramento

Comeau

et al. 2022

IJNS

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Testing immunoreactive trypsinogen (IRT) is the first step in cystic fibrosis (CF) newborn screening. While high IRT is associated with CF, some cases are missed. This survey aimed to find factors associated with missed CF cases due to IRT levels below program cutoffs. Twenty-nine states responded to a U.S-wide survey and 13 supplied program-related data for low IRT false screen negative cases (CFFN) and CF true screen positive cases (CFTP) for analysis. Rates of missed CF cases and odds ratios were derived for each factor in CFFNs, and two CFFN subgroups, IRT above (“high”) and below (“low”) the CFFN median (39 ng/mL) compared to CFTPs for this entire sample set. Factors associated with “high” CFFN subgroup were Black race, higher IRT cutoff, fixed IRT cutoff, genotypes without two known CF-causing variants, and meconium ileus. Factors associated with “low” CFFN subgroup were older age at specimen collection, Saturday birth, hotter season of newborn dried blood spot collection, maximum ≥ 3 days laboratories could be closed, preterm birth, and formula feeding newborns. Lowering IRT cutoffs may reduce “high” IRT CFFNs. Addressing hospital and laboratory factors (like training staff in collection of blood spots, using insulated containers during transport and reducing consecutive days screening laboratories are closed) may reduce “low” IRT CFFNs.

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Section: Discussionmentioning

confidence: 99%