Piper genus: source of natural products with anti-tyrosinase activity favored in phytocosmetics

Almeda, Fabiana; Astorga, Laura; Orellana, Andrea C.; Sampuel, Ligia; Sierra, Paola; Gaitán, Isabel; Cáceres, Armando

doi:10.15171/ijpni.2015.06

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…30 In a complementary research, anti-tyrosinase activity was studied in the same Piper species, demonstrating that two species (P. psilorhachis and P. umbellatum) have anti-tyrosinase activity, as well as two other species (P. jacquemontianum and P. variabile) that does not demonstrated urease inhibitory activity in this study. 31 It can be concluded that there are two compounds in P. psilorhachis, which act as inhibitors since they have different Rf values, although it is not necessarily an imidazole, but the Rf is close to omeprazole, the control compound (Rf 5.0). It is demonstrated that three species of Piper genus could have a potential application in the control of H. pylori and other chronic infections with urease-producing bacteria in the gastrointestinal and urinary tracts.…”

Section: Resultsmentioning

confidence: 99%

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

Cáceres¹,

Almeda²,

Astorga³

et al. 2018

Int J Phytocos Nat Ingred

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Introduction: Urease is an enzyme that catalyzes the hydrolysis of urea in the gastrointestinal and urinary systems, related with chronic bacterial infection. Piper is a basal angiosperm genus with ethnobotanical application. The aim of this study was to determine urease inhibitory activity of extracts from ten Guatemalan Piper species. Methods: Leaves from 7 species were collected in Suchitepequez (P. amalago, P. auritum, P. hispidum, P. jacquemontianum, P. oradendron, P. retalhuleuense, and P. umbellatum), and 3 in Alta Verapaz (P. psilorhachis, P. sempervirens, and P. variabile), shade-dried and milled. Dichloromethane (DCM) and methanol (MeOH) extracts were prepared by percolation and concentrated by rotavapor. The inhibitory effect was determined by enzymatic assays, qualitative by thin layer chromatography developed by phenol red; and quantitative by spectrophotometric kinetic method evaluated by microcolorimetry at 630 nm with phenol red. Results: Seventeen extracts out of 20 demonstrated anti-urease activity by TLC, showing one discoloration band with Rf 1.4-5.8; P. psilorhachis showed 2 discolorations bands at Rf 5.3 and 5.8, and the best activity (IC 50 MeOH 1.9 ± 0.08 μg/mL and DCM 2.1 ± 06 μg/mL), similar to positive control (hydrocyclohexanone IC 50 1.4 ± 0.05 µg/mL). Two other species, P. umbellatum (IC 50 MeOH 2.5 ± 0.06 µg/mL) and P. retalhuleunse (IC 50 MeOH 4.1 ± 0.7 µg/mL, DCM 4.8 ± 0.06 µg/mL) showed a moderate activity. Conclusion: Three species showed interesting anti-urease activity that deserves future studies by bioguided fractionation. Literature review demonstrated that this is the first report about the urease activity of these Piper species.

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Section: Resultsmentioning

confidence: 99%

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

Cáceres¹,

Almeda²,

Astorga³

et al. 2018

Int J Phytocos Nat Ingred

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“…This report is the first of an antifungal effect of P. neesianum against F. equiseti and F. oxysporum. The dichloromethane extract from leaves of P. neesianum has been reported to have various biological activities as an antioxidant (IC 50 = DPPH 0.071 mg/mL) [ 54 ], anti-tyrosinase (IC 50 = 6.6 µg/mL [ 55 ] and anti-urease (IC 50 = 12.9 µg/mL) [ 56 ]. Essential oil from P. neesianum leaves collected in the northern region of Guatemala contained bicyclogermacrene (28%), germacrene D (11.7%) and β-caryopyllene (7.5%) as major compounds among 19 detected in a gas chromatography with flame ionization detection- mass spectrometry analysis [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense

et al. 2020

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Fusarium equiseti strain FCHE and Fusarium oxysporum strain FCHJ were isolated from the roots of wilting habanero pepper (Capsicum chinense Jacq.) seedlings with root rot. Toward developing a biorational control of these serious phytopathogenic strains, ethanolic (EE) and aqueous (AE) extracts of different vegetative parts of 40 tropical native plants of the Yucatán Peninsula were screened for antifungal activity. Extracts of six out of 40 assayed plants were effective, and the most inhibitory extracts were studied further. EEs from Mosannona depressa (bark from stems and roots), Parathesis cubana (roots), and Piper neesianum (leaves) inhibited mycelial growth of both strains. Each active EE was then partitioned between hexane and acetonitrile. The acetonitrile fraction from M. depressa stem bark (MDT-b) had the lowest minimum inhibitory concentration of 1000 µg/mL against both pathogens and moderate inhibitory concentration (IC50) of 462 against F. equiseti and 472 µg/mL against F. oxysporum. After 96 h treatment with EE from M. depressa stem bark, both strains had distorted hyphae and conidia and collapsed conidia in scanning electron micrographs. Liquid chromatography–ultraviolet–high resolution mass spectrometry analysis revealed that the major component of the fraction was α-asarone. Its antifungal effect was verified using a commercial standard, which had an IC50 of 236 µg/mL against F. equiseti and >500 µg/mL against F. oxysporum. Furthermore, the P. cubana hexane fraction and P. neesianum acetonitrile fraction had antifungal activity against both Fusarium pathogens. These compounds provide new options for biorational products to control phytopathogenic fungi.

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“…The search for natural melanogenesis inhibitors in recent years has demonstrated that plant extracts could be potential sources of new whitening ingredients as potent as synthetic whitening agents but not associated with cytotoxicity or mutagenicity (Figure 2) [19,55,67,152]. Classification of these whitening components, based on their structure and the mechanism by which they interfere with melanogenesis, is difficult, notably because of their huge number, the fact that some of them act at several levels, and the variety of tests used to assess their whitening potency [79].…”

Section: State Of the Artmentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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Abstract:With the public's growing interest in skin whitening, lightening ingredients only used under dermatological supervision until recently, are more and more frequently incorporated into cosmetic formulas. The active agents that lighten skin tone are either natural or synthetic substances, and may act at various levels of melanogenesis. They are used to treat various skin pigmentation disorders or simply to obtain a lighter skin tone as whiter skin may be synonymous of wealth, health, youth, and/or beauty in different cultures. However, recent studies demonstrated the adverse effects of some of these ingredients, leading to their interdiction or restricted use under the European Directive and several other international regulations. After an overview of skin whitening practices and the associated risks, this article provides insight into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients. The legislation dealing with the use of skin lighteners is then discussed. As traditional depigmenting agents such as hydroquinone and corticosteroids are of safety concern, the potential of natural extracts has been investigated more and more; finally, a synthesis of three years of research in our laboratory for such plant extracts will be given.

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Piper genus: source of natural products with anti-tyrosinase activity favored in phytocosmetics

Cited by 7 publications

References 21 publications

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

Anti-urease activity of native species of genus Piper from Guatemala with potential application in infection control

Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

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