Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties

Tan, Li Ying; Yin, Wai‐Fong; Chan, Kok‐Gan

doi:10.3390/s130303975

Cited by 49 publications

(36 citation statements)

References 42 publications

(34 reference statements)

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“…Additionally, the extracts used in the study did not have any antibacterial activity against all test strains. The present data is supported well with the findings of Tan et al (2013) who reported the anti-QS activity of methanolic extracts of Pip. nigrum against Chr.…”

Section: Discussionsupporting

confidence: 93%

Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains

et al. 2016

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The present study investigated plant extracts for their anti-quorum-sensing (QS) potential to inhibit the biofilm formation in Cronobacter sakazakii strains. The bioassay based on loss of pigment production by Chromobacterium violaceum 026 and Agrobacterium tumefaciens NTL4 (pZLR4) was used for initial screening of the extracts. Further, the effect of extracts on the inhibition of QS-mediated biofilm in C. sakazakii isolates was evaluated using standard crystal violet assay. The effect on biofilm texture was studied using SYTO9 staining and light and scanning electron microscopy. Among the tested extracts, Piper nigrum and Cinnamomum verum at 100 ppm resulted in 78 and 68 % reduction in the production of violacein as well as blue-green colour in both biosensor strains. A higher inhibitory activity (>50 %) on biofilm formation in C. sakazakii was observed for Pip. nigrum and Cin. verum, whereas the other extracts possessed moderate (25-50 %) and minimal (<25 %) inhibitory activities. Further, the fluorescent and scanning electron microscopic images indicated a major disruption in the architecture of biofilms of tested strains by Pip. nigrum. This study points to the possibility of using Pip. nigrum and Cin. verum as inhibitor of QS-mediated biofilm formation by C. sakazakii that could be further explored for novel bioactive molecules to limit the emerging infections of C. sakazakii.

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Section: Discussionsupporting

confidence: 93%

Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains

et al. 2016

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“…On account of the importance of such quorum-sensing-inhibitor (QSI) compounds, many studies have recently shown that AHLmediated mechanism could be considered as a promising target on achieving some novel pathways for paralyzing the QS such as Eugenol isolated from clove 7,11,29 . It has been found that the extract from Melicope lunu-ankenda inhibited QS-controlled virulence factors of the human pathogen, P. aeruginosa PAO1 22 . The ethanolic extract isolated from Scutellaria baicalensis Georgi was confirmed to be able to suppress the QS-dependent virulence determinant in Pectobacterium 20 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition to D. pulchra, various higher plants including Medicago truncatula seedlings 9 , garlic, clove 24 , Tremella fuciformis, water lily (Nymphaea sp. ), and pepper extracts 22 were also shown to secrete AHL signal mimic substances and were found to possess anti-QS activity. The finding of QS inhibitor compounds in plants raises the possibility that interfering bacterial quorum sensing using AHL mimic compounds might be of considerable medical and agricultural interest in controlling of bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

Anti-quorum Sensing Effetcs of Ethanolic Crude Extract ofAnethum graveolensL.

Makhfian

Hassanzadeh

Mahmoudi

et al. 2015

Journal of Essential Oil Bearing Plants

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In the recent years, effort to interfere with the quorum sensing (QS) has taken researchers consideration into the discovery and identification of bioactive compounds secreted by prokaryotes and eukaryotes. In this research, the anti-QS activity of thirty one plant species was detected through the inhibition of the QS related behaviors, violacein pigmentation in Chromobacterium violaceum CV026 and plant tissue maceration in Pectobacterium carotovorum. The results revealed that the arial parts extract of seven plant species interfered quorum sensing phenotypes in bacteria which amoung them, the dill (Anethum graveolens L.) extract effectively inhibited violacein production in CV026 and singificantly reduced tissue maceration in test plants. The result substantiates that the dill extract has decreased (>13 mm) violacein production in biosensor besides possessing slight antimicrobial property (<7.5 mm). Both potato tubers and calla-lily slices inoculated with Pcc-extract showed significant reduction in tissue maceration, while the tubers and slices inoculated with Pcc and Pcc-DMSO were strongly macerated. GC-MS analysis of the A. graveolens extract indicated that the oil was consisted eight phytocompounds of which the Eugenol (49.62 %) as major component. This results suggest that plants have mimic quorum-sensing signals which could be serving as potential sources to disrupt quorum sensing in associated bacteria.

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“…Adonizio et al [13] highlighted antiquorum sensing (AQS) compounds that may be very promising in the treatment of chronic infections caused by biofilm forming microorganisms. AQS properties of natural compounds are well documented in the literature [13][14][15][16][17]. AQS treatment may be a reliable way to reduce bacterial virulence and attenuate the acquisition of drug resistance by pathogenic bacteria [12].…”

mentioning

confidence: 99%

Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa

Bukvički

Ćirić

Soković

et al. 2016

Natural Product Communications

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The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was tested against six bacterial and seven fungal strains and high antimicrobial potential was noticed. Minimum inhibitory concentration varied from 0.031 mg/mL to 0.5 mg/mL for bacterial and 0.062 mg/mL to 0.5 mg/mL for fungal strains. The antiquorum properties of the essential oil were evaluated on Pseudomonas aeruginosa PAO1. The oil was tested at subMIC concentrations for anti-quorum sensing activity. The analyses on quorum-sensing functions have been carried out by evaluating twitching and swarming of bacterial cultures and the total amount of pyocyanin production produced by P. aeruginosa. This study showed that M. thymifolia essential oil exhibited antiquorum sensing activity and may be used as an antipathogenic drug.

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Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties

Cited by 49 publications

References 42 publications

Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains

Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains

Anti-quorum Sensing Effetcs of Ethanolic Crude Extract ofAnethum graveolensL.

Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa

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