Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus

Khalili-Fomeshi, Mohsen; Azizi, Mohammad Golparvar; Esmaeili, Mohammad; Gol, Mohammad; Kazemi, Sohrab; Ashrafpour, Manouchehr; Moghadamnia, Ali Akbar; Hosseinzadeh, Soheila

doi:10.1016/j.bbr.2017.09.031

Cited by 33 publications

(9 citation statements)

References 30 publications

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“…The results of cognitive function were consistent with a reduced level of malondialdehyde in cerebrospinal fluid (CSF) and hippocampus (HC) of the treated rats. Based on the described results, the cognitive-enhancing effect of piperine was attributed to its positive effects on the redox balance of CSF and HC neurons [114]. In a pilocarpine-induced rat model of epilepsy, administration of piperine reduced oxidative stress and inflammation and ameliorated memory impairment [91].…”

Section: Neuroprotective and Other Neurological Effects Of Piperinementioning

confidence: 98%

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

et al. 2019

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Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs.

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Section: Neuroprotective and Other Neurological Effects Of Piperinementioning

confidence: 98%

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

et al. 2019

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“…Piper nigrum, or black pepper, has been widely utilized in several traditional medicine systems such as the Unani and Ayurvedic systems [24]. Black pepper has been reported as a potential treatment for cognitive dysfunction and neurodegeneration in AD [25][26][27]. Centella asiatica has been used for a long time in Ayurvedic traditions as a brain tonic and a memory enhancer [28].…”

Section: Introductionmentioning

confidence: 99%

Multitarget Activities of Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Against Alzheimer’s Disease

et al. 2020

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The Kleeb Bua Daeng formula (KBD) is a Thai traditional medicine for brain health promotion. On the basis of the activities of its individual components, the KBD could have good potential for the treatment of Alzheimer’s disease (AD). Herein, we investigated the KBD as an AD treatment. The ethanol extracts of KBD and its components, i.e., Nelumbo nucifera (NN), Piper nigrum fruits (BP), and the aerial part of Centella asiatica (CA) exhibited antioxidant activity, as determined by both ABTS and DPPH assays. The Ellman’s assay revealed that the KBD, NN, and BP showed an ability to inhibit acetylcholinesterase. The thioflavin T assay indicated that the KBD, NN, BP, and CA inhibited beta-amyloid aggregation. The neuroprotection and Western blot analysis revealed that the KBD reduced H2O2-induced neuronal cell death by inhibiting the expression of pro-apoptotic factors, i.e., cleaved caspase-9 and -3, p-P65, p-JNK, and p-GSK-3β, as well as by inducing expression of anti-apoptotic factors, i.e., MCl1, BClxl, and survivin. Furthermore, the KBD could improve scopolamine induced memory deficit in mice. Our results illustrate that the KBD with multimode action has the potential to be employed in AD treatment. Thus, the KBD could be used as an alternative novel choice for the prevention and treatment of patients with AD.

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“…In clinical trials, also improvement in cognition has been reported in patients with mild-to-moderate AD treated with C. sativus extract (Akhondzadeh et al, 2010). Moreover, Piperine, (main alkaloid constituent of P. nigrum) and P. nigrum extract exhibited beneficial effects in various models of memory impairment (Chonpathompikunlert, Wattanathorn, & Muchimapura, 2010;Khalili-Fomeshi et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative damage following cerebral ischemia in rat hippocampus has been reported to attenuate with Safranal treatment, an active constituent of C. sativus (Hosseinzadeh & Sadeghnia, 2005). Studies have also demonstrated that P. nigrum and its active constituent Piperine reduce oxidative stress in the brain and periphery (Hritcu et al, 2014;Khalili-Fomeshi et al, 2018;Srinivasan, 2007;Vijayakumar, Surya, & Nalini, 2004).…”

Section: Discussionmentioning

confidence: 99%

The effects of the combination ofCyperus rotundus,Crocus sativus,Piper nigrum,andBoswellia serrataon learning and memory deficit and oxidative damage in brain tissue of hypothyroid rats

et al. 2020

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In the present study, the impact of a combination of four memory‐enhancer herbs on cognitive impairment and brain tissue oxidative damage due to hypothyroidism was evaluated. Propylthiouracil (PTU; 0.05%) was administrated in drinking water. Rats were treated with a combination of four herbal products (Cyperus rotundus, Crocus sativus, Piper nigrum, and Boswellia serrata) mixed with honey at two doses (640 and 1,280 mg/kg) or donepezil (0.5 mg/kg), for 6 weeks. Memory performance on the Morris water maze (MWM) and avoidance behavior in passive avoidance was impaired by hypothyroidism, and brain tissue oxidative damage occurred. Herbal combination and donepezil significantly improved memory impairment, reduced malondialdehyde concentration, and nitric oxide metabolites while increased the thiol contents and catalase and superoxide dismutase enzymes activity in the brain. Our findings suggest that the mixture of herbal products improves learning and memory deficits caused by hypothyroidism, probably by reducing the brain tissue oxidative damage. Practical applications Learning and memory impairment is a common feature of thyroid hormones deficiency. Several studies are showing that hypothyroidism in juvenile and mature rats induces significant cognitive impairment. Likewise, in humans, a close relationship between thyroid hormone deficiency and cognitive impairment has been reported. We used a mixture of herbal products, including Cyperus rotundus, Crocus sativus, Piper nigrum, and Boswellia serrata, to treat hypothyroidism‐induced memory impairment. All these herbs are widely used as a food additive across the world. In Iranian traditional medicine, this herbal combination traditionally used to treat cognitive impairments. Numerous studies have indicated that these herbs show neuroprotective and memory‐enhancing properties. Our finding indicated that a traditionally used herbal combination could potentially use as a treatment of cognitive impairment induced by thyroid hormone deficiency.

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Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus

Cited by 33 publications

References 30 publications

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Multitarget Activities of Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Against Alzheimer’s Disease

The effects of the combination ofCyperus rotundus,Crocus sativus,Piper nigrum,andBoswellia serrataon learning and memory deficit and oxidative damage in brain tissue of hypothyroid rats

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