Piperine, the potential functional food for mood and cognitive disorders

Wattanathorn, Jintanaporn; Chonpathompikunlert, Pennapa; Muchimapura, Supaporn; Priprem, Aroonsri; Tankamnerdthai, Orathai

doi:10.1016/j.fct.2008.06.014

Cited by 159 publications

(106 citation statements)

References 19 publications

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“…Piperine has been found to enhance the therapeutic efficacy of many drugs, vaccines and nutrients by increasing oral bioavailability by inhibiting various metabolising enzymes [8]. It is also known to enhance cognitive action and Fertility [9]. Piperine also found to stimulate the pancreatic and intestinal enzymes which aid to digestion.…”

Section: Introductionmentioning

confidence: 99%

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri

Ahmad²

2014

Medicinal Aromatic Plants

159

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Section: Introductionmentioning

confidence: 99%

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri

Ahmad²

2014

Medicinal Aromatic Plants

159

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“…4) The results from animal experiments showed that PIP possesses antidepression hyphen like activity and cognitive-enhancing effect after chronic oral administration. 5) It was demonstrated that the antidepressant properties of PIP are mediated via the regulation of serotonergic system; chronic treatment of PIP enhances the serotonin levels in the hypothalamus and hippocampus. 6) It is also reported that up regulation of progenitor cell proliferation of hippocampus and cytoprotective activity might be mechanisms involved in the antidepressantlike effect of PIP, which may be closely related to elevation of hippocampal brain-derived neurotrophic factor (BDNF) level.…”

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confidence: 99%

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Sun

Zuo

2010

Biological & Pharmaceutical Bulletin

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It was previously reported that piperine (PIP) significantly blocks convulsions induced by intracerebroventricular injection of threshold doses of kainate, but had no or only slight effects on convulsions induced by L-glutamate, N-methyl-D-aspartate and guanidinosuccinate. In traditional Chinese medicine, black pepper has been used for epileptic treatment; however, the exact mechanism is still unclear. We reported here in that appropriate concentration of PIP effectively inhibites the synchronized oscillation of intracellular calcium in rat hippocampal neuronal networks and represses spontaneous synaptic activities in terms of spontaneous synaptic currents (SSC) and spontaneous excitatory postsynaptic currents (sEPSC). Moreover, pretreatment with PIP expects protective effect on glutamate-induced decrease of cell viability and apoptosis of hippocampal neurons. These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca 2؉ overloading.

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“…Liet in his study says that antidepressant potential of piperine was to be mediated via the regulation of serotonergic system, whereas antilepsirine antidepressant action might be mediated via dual regulation of both serotonergic and dopaminergic systems [108]. In another study, piperine shows antidepressant like activity and cognitive effect during entire duration of treatment in Wister male rats at various doses ranging from 5, 10 and 20 mg/kg/day [62].…”

Section: Antidepressant Potentialmentioning

confidence: 99%

“…Another study shows that piperine posseess promising CNS action when it fed to rats decreases the pain perception relieving β-endophins in brain [61]. Recently, an interesting study shows that piperine was also effective in mood and cognitive disorder [62]. Piperine and their derivatives showed anticonvulsant action which had been demonstrated in mice and rats [63,64].…”

Section: Effects On Cns and Nerve Conductivitymentioning

confidence: 99%

Piperine and Its Various Physicochemical and Biological Aspects: A Review

Chopra¹,

Dhingra²,

Kapoor³

et al. 2016

CHEM

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Abstract:Piper nigrum L. is examined as the king of species worldwide by virtue of its principle piperine. In Ayurveda, since from the ancient times, it is known as "Yogvahi". It is one of the important alkaloids of Pepper fruits (Family Piperaceae) and has been found to have numerous medicinal properties such as antioxidant, antiplatelet, anti-inflammatory, antihypertensive, hepatoprotective, antithyroid, antitumor, antiasthmatic activity and also have significant role as fertility enhancer. The present review discusses the biosynthetic pathway, extraction process, chemistry and various analytical methods of piperine. It also describes the structural modification of piperine and its various effects on biological system. The utility of piperine as a bioenhancer for certain antibacterialantibiotics and a potent inhibitor of drug metabolism are also discussed. Thus, review provides knowledgeable erudition on the piperine which paves way for further work.

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Piperine, the potential functional food for mood and cognitive disorders

Cited by 159 publications

References 19 publications

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Piperine and Its Various Physicochemical and Biological Aspects: A Review

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