Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer

Huang, Jingmin; Wang, Sheng-Te; Wei, Meng-Ning; Liu, Kun; Fu, Jingwen; Xing, Zihao; Shi, Zhi

doi:10.3389/fphar.2020.586885

Cited by 11 publications

(4 citation statements)

References 22 publications

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“…The positive group and the EO dose group could reduce the damage of colon epithelia caused by DSS, also could inhibit inflammatory cell infiltration, and could maintain the integrity of intestinal epithelia and crypt glands. Huang et al found similar results [ 52 ]. The histological score of mice in DSS group was significantly higher than that in normal group ( P < 0.01).…”

Section: Resultssupporting

confidence: 61%

Extraction, Chemical Composition, and Protective Effect of Essential Oil from Chimonanthus nitens Oliv. Leaves on Dextran Sodium Sulfate-Induced Colitis in Mice

Zhang

Ouyang

et al. 2022

Oxidative Medicine and Cellular Longevity

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In this study, the essential oil (EO) was extracted by steam distillation from Chimonanthus nitens Oliv, and the extraction process was optimized by response surface methodology. The optimum process conditions are as follows: extraction time of 4.57 h, soaking time of 1.33 h, and solid-liquid ratio of 1 : 21.4. Under these conditions, the theoretical yield of EO is 1.5624%. The EO compounds were analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 52 chemical components were detected, among which the content of 3-(4,8-dimethylnona-3,7-dienyl)-furan was the highest, accounting for 21.43% of the total peak area. The EO showed good antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 ′ -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and reducing power. In this study, we observed the protective effect of EO on ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) in mice. EO effectively delayed weight loss and reduced DAI score. Histological examination also observed a significant reduction in damage in the EO group. The colon length of mice in DSS group was the shortest, and the colon length of mice in EO treatment group was longer than that in model group, but shorter than that in normal group ( NOR : 8.17 ± 0.39 cm ; DSS : 5.57 ± 0.93 cm ; L − EO : 6.47 ± 0.78 cm ; M − EO : 5.98 ± 0.58 cm ; and H − EO : 6.1 ± 0.52 cm ). The GSH activity in the L-EO and SASP groups was significantly higher than that in the DSS group ( P < 0.01 ). SOD activity in L-EO and M-EO groups was also significantly higher than that in DSS treatment group ( P < 0.01 ). MDA was decreased in the EO treatment groups and the SASP group (L-EO, H-EO, SASP: P < 0.01 ; M-EO: P < 0.05 ). MPO of EO treatment group was lower than that of model group (the L-EO group was not significant, M-EO: P < 0.05 , H-EO: P < 0.05 ). This study shows that EO can effectively improve the symptoms of colitis.

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Section: Resultssupporting

confidence: 61%

Extraction, Chemical Composition, and Protective Effect of Essential Oil from Chimonanthus nitens Oliv. Leaves on Dextran Sodium Sulfate-Induced Colitis in Mice

Zhang

Ouyang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…To improve the prognosis of HBV-HCC patients, we screened 13 small molecule compounds using the CMap database. Piperlongumine can reduce colitis-associated colorectal cancer ( 40 ) and relieve sepsis by attenuating the activation of inflammasomes ( 41 ). From the enrichment results, piperlongumine acts on the HIF-1 signaling pathway and lyase activity, while fisetin regulates NF-kB transcription factor activity.…”

Section: Discussionmentioning

confidence: 99%

Genomic analysis quantifies pyroptosis in the immune microenvironment of HBV-related hepatocellular carcinoma

Zhang

et al. 2022

Front. Immunol.

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Pyroptosis, a way of pro-inflammatory death, plays a significant part in the tumor microenvironment (TME). A recent study has shown that the hepatitis C virus changes the TME by inducing pyroptosis against hepatocellular carcinoma (HCC). However, compared to TME in hepatitis C virus-infected HCC, the exploration of immune characteristics and response to immunotherapy associated with the pyroptosis phenotype is still insufficient in hepatitis B virus-related HCC (HBV-HCC). Our study constructed pyroptosis-score (PYS) via principal-component analysis (PCA) to unveil the link between pyroptosis and tumor immunity in 369 HBV-HCC patients. Compared with the low-PYS group, subjects with higher PYS were associated with poor prognosis but were more susceptible to anti-PD-L1 treatment. In addition, we found that PYS can serve independently as a prognostic factor for HBV-HCC, making it possible for us to identify specific small molecule drugs with a potential value in inhibiting tumors via targeting pyroptosis. Also, the target genes predicted by the Weighted gene co-expression network analysis (WGCNA) and pharmacophore model were enriched in the HIF-1 signaling pathway and NF-kB transcription factor activity, which were related to the mechanism of inflammation-driven cancer. The PYS is extremely important in predicting prognosis and responses to immunotherapy. New treatment strategies for inflammation-driven cancers may be found by targeting pyroptosis.

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“…These doses of PLM were shown to have therapeutic effects against tumor growth in mice without causing obvious adverse effects. 27,28 Meanwhile, mice in the Sham and OVX groups were treated with vehicle solution in the same manner as described above. All injections were given once daily for 6 weeks.…”

Section: Ovariectomy (Ovx)-induced Osteoporosismentioning

confidence: 99%

Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling

Luo,

Zhang,

Xiu

et al. 2024

Food Funct.

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Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer

Cited by 11 publications

References 22 publications

Extraction, Chemical Composition, and Protective Effect of Essential Oil from Chimonanthus nitens Oliv. Leaves on Dextran Sodium Sulfate-Induced Colitis in Mice

Extraction, Chemical Composition, and Protective Effect of Essential Oil from Chimonanthus nitens Oliv. Leaves on Dextran Sodium Sulfate-Induced Colitis in Mice

Genomic analysis quantifies pyroptosis in the immune microenvironment of HBV-related hepatocellular carcinoma

Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling

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