Pipradrol and Pipradrol Derivatives

White, Michael; Archer, John R. H.

doi:10.1016/b978-0-12-415816-0.00010-9

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…[84] There has been one poisons information service case series describing cases of acute pipradrol toxicity, this complements reports from clinical toxicology services. A number of pipradrol derivatives have been reported including desoxypipradrol (2-diphenylmethylpiperidine, 2-DPMP) and the pyrrolidine derivatives, diphenylprolinol and 2-(diphenylmethyl)pyrrolidine.…”

Section: Benzofuransmentioning

confidence: 99%

Using poisons information service data to assess the acute harms associated with novel psychoactive substances

Wood

Hill

2014

Drug Testing and Analysis

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Novel psychoactive substances (NPS) can cause significant acute toxicity but usually little is known about their toxicity when they enter the recreational drug scene. Current data sources include online user forums, user questionnaires, case reports/series, and deaths; however, these are limited by their focus on sub-populations and generally include severe cases and specific geographical areas. Approximately 54% of countries have at least one poisons information service (in 2012 there were 274 worldwide) providing advice to healthcare professionals and/or the public on poisoning. They provide advice on recreational drug and NPS toxicity. In 2012, 2.5% of telephone enquiries to the UK National Poisons Information Service and 2.4% of enquiries to US poisons centres related to recreational drugs. Data are collected at population level and can be used to complement other data sources with clinical details on acute NPS toxicity and geographical/time patterns of toxicity. Like other acute NPS toxicity data, poisons centre data should be interpreted within their limitations, notably the absence of analytical confirmation and reliance on secondary reporting of clinical features. This manuscript demonstrates the breadth and depth of poisons information service data in the literature with a focus on mephedrone and synthetic cannabinoid-receptor agonists. In our opinion it would be possible to develop a more robust and systematic reporting system using a network of poisons information services both within and across countries that would be complimentary to other datasets on acute NPS toxicity and allow more accurate data triangulation.

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Section: Benzofuransmentioning

confidence: 99%

Using poisons information service data to assess the acute harms associated with novel psychoactive substances

Wood

Hill

2014

Drug Testing and Analysis

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Chemoinformatic Consideration of Novel Psychoactive Substances: Compilation and Preliminary Analysis of a Categorised Dataset

Firman

Belfield

Jackson

et al. 2019

Molecular Informatics

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This paper is dedicated to Prof. Paola Gramatica on the occasion of her retirement.Abstract: Recent years have seen the emergence into circulation of a growing array of novel psychoactive substances (NPS). Knowledge of the pharmacological profiles and risk liability of these compounds is typically very scarce. Development of chemoinformatic tools enabling prediction of properties within uncharacterised analogues has potential be of particular use. In order to facilitate this, compilation of a chemical inventory comprising known NPS is a necessity. Sourcing a variety of published governmental and analytical reports, a dataset composed of 690 distinct acknowledged NPS, complete with defined chemical structures, has been constructed. This is supplemented by a complementary series of 155 established psychoactive drugs of abuse (EPDA). Classification was performed in accordance with their key molecular structural features, subjective effect profiles and pharmacological mechanisms of action. In excess of forty chemical groupings, spanning seven subjective effect categories and six broad mechanisms of pharmacological action, were identified. Co-occurrence of NPS and EPDA within specific classes was common, showcasing inherent scope both for chemical read-across and for the derivation of structural alerts.

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Treatment with Metal-Organic Frameworks (MOFs) elicits secondary metabolite accumulation inAquilaria crassna(Agarwood) callus culture

Overmans,

Alflayyeh,

Gutiérrez

et al. 2024

Preprint

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Thymelaceaous trees are prized for accumulating fragrant resins composed of hundreds of secondary metabolites in their woody tissues. Slow growth and increasing consumer demand have stretched natural sources of agarwood trees to being endangered and alternative production modes, including silviculture and tissue culture, are currently being investigated. Dedifferentiated tissue culture of agarwood trees provide a means of cell propagation independent of environmental context. However, secondary metabolite accumulation as found in fragrant resins, occurs largely in response to wounding. Here, we investigated the application of metal-organic frameworks (MOFs) as potential elicitors of secondary metabolite formation in Aquilaria crassna tissue culture samples. Callus cultures were exposed to five commercially available MOFs: UiO-67, MOF-808, HKUST-1, ZIF-67, and MOF-74, and ethanol extracts were used to quantify secondary metabolite accumulation compared to untreated cultures. Samples that were exposed to Zr-based MOFs exhibited similar metabolite production profiles, (trans-2-Carboxy-cyclo-hexyl)-acetic acid was reduced in the presence of all MOFs, the Cu-containing HKUST-1 MOF increased palmitic acid levels, and MOF-808 and ZIF-67 were found to elicit the highest accumulation of secondary metabolites with potential fragrance applications. These results demonstrate the possibility of eliciting secondary metabolites from dedifferentiated agarwood tree cell culture and may provide an alternative means of sourcing fragrant specialty chemicals from these plants.

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Pipradrol and Pipradrol Derivatives

Cited by 3 publications

References 50 publications

Using poisons information service data to assess the acute harms associated with novel psychoactive substances

Using poisons information service data to assess the acute harms associated with novel psychoactive substances

Chemoinformatic Consideration of Novel Psychoactive Substances: Compilation and Preliminary Analysis of a Categorised Dataset

Treatment with Metal-Organic Frameworks (MOFs) elicits secondary metabolite accumulation inAquilaria crassna(Agarwood) callus culture

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