Pirenzepine Blunts the Pulmonary Parenchymal Response to Inhaled Methacholine

Sly, Peter D.; Willet, Karen E.; Kano, Sohei; Lanteri, Celia J.; Wale, Janet

doi:10.1006/pulp.1995.1015

Cited by 16 publications

(14 citation statements)

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“…However, in our previous report, 6 we demonstrated that the degree of inhibition of the parenchymal response by the relatively selective M1 subtype muscarinic receptor antagonist, pirenzepine, was identical in the two groups of animals, despite the differences in their Mch sensitivity. This finding suggests that up-regulation of the expression of muscarinic receptors is not responsible, at least for the differences in parenchymal responsiveness.…”

Section: Discussioncontrasting

confidence: 46%

“…Neither the present study nor our previous report 6 can determine the mechanism for the increased Mch responsiveness reported in animals exposed to an external environment. However, in our previous report, 6 we demonstrated that the degree of inhibition of the parenchymal response by the relatively selective M1 subtype muscarinic receptor antagonist, pirenzepine, was identical in the two groups of animals, despite the differences in their Mch sensitivity.…”

Section: Discussionmentioning

confidence: 52%

“…However, in that study, 6 the two groups of pups were of different breeds; the animal house pups were foxhound-beagle cross, whereas the external pups were mongrels. Thus, we could not exclude a genetic basis for the differences in Mch responsiveness reported.…”

Section: Discussionmentioning

confidence: 96%

“…In a previous study, we noticed differences in Mch responsiveness between puppies born and raised in a clean animal house environment and those born and raised in an external environment, 6 raising the possibility that environmental factors may have been responsible for these differences. However, in that study, 6 the two groups of pups were of different breeds; the animal house pups were foxhound-beagle cross, whereas the external pups were mongrels.…”

Section: Discussionmentioning

confidence: 97%

“…For example, in the puppy model, hypertonic saline alters lung function by an action purely in the airways, 5 histamine alters lung function by an action predominantly in the parenchyma, 2 whereas Mch acts on both the airways and parenchyma. 1 In a recent study, 6 we observed unexpected differences in the Mch responsiveness of the parenchyma, but not of the airways, in two breeds of puppies. In that study, the parenchyma of foxhound-beagle cross puppies was significantly less responsive to Mch than that of mongrel puppies.…”

Section: Introductionmentioning

confidence: 84%

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Environmental effects on pulmonary mechanics and the response to inhaled methacholine

Sly¹,

Willet²,

Habre³

1998

Pediatr. Pulmonol.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 84%

See 3 more Smart Citations

Environmental effects on pulmonary mechanics and the response to inhaled methacholine

Sly¹,

Willet²,

Habre³

1998

Pediatr. Pulmonol.

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Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets

1998

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The aim of our study was to determine the effects of pulmonary vascular engorgement on airways and pulmonary tissues in juvenile animals before and after methacholine (Mch)‐induced changes in lung function. Five anesthetized, paralyzed, and thoracotomized piglets were studied before and during pulmonary vascular engorgement, induced by inflating a left atrial balloon catheter and by calculating respiratory mechanics from measurements of airway opening (Pao) and alveolar pressures (PA), respiratory flow (V′), and volume (V) recorded during mechanical ventilation, using the multilinear regression technique. A maximal increase of 15 mmHg in pulmonary artery pressure (Ppa) resulted in a mean increase in total lung elastance (EL) of 28.6% and in total lung resistance (RL) of 14.9%. Mch increased EL by 21.7% and RL by 29.0%. Inflation of the left atrial balloon with an associated increase in Ppa by 15 mmHg in the presence of Mch resulted in an increase in EL by a further 12.4% (to 135.4% of baseline) and in RL by a further 9.0% (to 139.5% of baseline). The change in RL was associated with a qualitatively similar change in both tissue resistance (Vti) and airway resistance (Raw) before and after Mch‐induced changes in lung function. We conclude that increasing pulmonary vascular pressures, by increasing left artial pressure, alters lung function in juvenile animals by altering the mechanical properties of both airways and lung tissues. The methods used in the present study allow a direct assessment of the site of action of vascular engorgement in the lungs and provide a useful model for studying this phenomenon further. Pediatr. Pulmonol. 1998; 25:45–51. © 1998 Wiley‐Liss, Inc.

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