piRNA-mediated transposon regulation and the germ-line mutation rate in Drosophila melanogaster males

Simmons, Michael; Peterson, Mark P.; Thorp, Michael W.; Buschette, Jared T.; DiPrima, Stephanie; Harter, Christine L.; Skolnick, Matthew J.

doi:10.1016/j.mrfmmm.2015.01.011

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…We can therefore conclude that some chromatin-organizing proteins, such as HP1, act upstream or downstream of piRNAs to regulate transposons. Mutations in Aub, PIWI, and Su(var)205 are known to increase the activity of transposable elements in germline cells (37,38) (Fig. 1).…”

Section: Epigenetic Functions Of Specific Transposable Elementsmentioning

confidence: 99%

Epigenetic roles of PIWI‑interacting RNAs (piRNAs) in cancer metastasis (Review)

2018

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P‑element‑induced wimpy testis (PIWI)‑interacting RNAs (piRNAs) are epigenetic‑related short ncRNAs that participate in chromatin regulation, transposon silencing, and modification of specific gene sites. These epigenetic factors or alterations are also involved in the growth of a variety of human cancers, including lung, breast, and colon cancer. Accumulating evidence has revealed that tumor metastasis and invasion involve genetic and epigenetic factors. Cancer metastasis is characterized by epigenetic alterations including DNA methylation and histone modification. Changes in DNA methylation, H3K9me3 heterochromatin and transposable elements have been detected in several cancers. piRNAs may function in gene silencing and gene modification upstream or downstream of oncogenes in cancer cell lines or cancer tissues. In addition to piRNAs, PIWI proteins can be used as biomarkers for prognosis, diagnosis and clinical evaluation and may be factors in cancer metastasis. Here, we elucidated the possible mechanisms by which piRNAs regulate cancer metastasis, including but not restricted to influencing DNA and histone methylation and transposable elements.

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Section: Epigenetic Functions Of Specific Transposable Elementsmentioning

confidence: 99%

Epigenetic roles of PIWI‑interacting RNAs (piRNAs) in cancer metastasis (Review)

2018

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“…Because these RNAs are found in complexes that contain members of the Piwi family of proteins, they have been called repeat-associated (ras) RNAs or Piwi-interacting (pi) RNAs [41][42][43]. In D. melanogaster, Piwi proteins are encoded by the genes aubergine (aub) and piwi from chromosome 2 and agonaute3 (ago3) from chromosome 3 [44]. It has been shown that mutant alleles of aub and piwi disrupt the regulation of the P element [40,45].…”

Section: Stock Of Mutationmentioning

confidence: 99%