Piroxicam-Collagen-Based Sponges for Medical Applications

Abstract

Depending on the concentration of the drug and/or the method of administration, drugs could be used in various ways. To take full advantage of the drug beneficial properties in oral medical interventions but also in other types of surgery, like plastic surgery, general surgery, or gynecological surgery, the drug concentration as well as the administration method itself will depend on the wound, type of surgery, and severity of the postoperative pain which can be very different. Generally, the local administration methods are recommended. Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, is generally used to relieve the symptoms of pain and inflammation. Starting from the idea of the special benefit of the interference between collagen-based materials and drug beneficial properties, our work was focused on the synthesis and characterization of new collagen-piroxicam materials. These new collagen-based materials present a good water absorption, and the piroxicam release suggests a biphasic drug release profile whereas the obtained values for the release exponent revealed a complex release mechanism including swelling, diffusion, and erosion.

Fabrication of gentamicin loaded Col-I/HA multilayers modified titanium coatings for prevention of implant infection

“…However, the micropores formed by alkali treatment were interconnected and had open porous structure, and do not have a controlled release effect. Many literatures have proved that both type I collagen and hyaluronic acid have excellent drug-loaded release properties ( Ray et al, 2013 ; Ioan et al, 2019 ; Bayer, 2020 ). Compared with TC-A-G, TC-AAC-G can load more drugs and has a better sustained release effect due to the grafted collagen.…”

Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

“…Collagen-based sponges were prepared starting from a collagen gel of 1.91% and acidic pH. This gel was obtained from bovine derma using a current technology at INCDTP—Division Leather and Footwear Research Institute, Collagen Department (Bucharest, Romania) [ 40 , 41 ]. Ciprofloxacin Hydrochloride (MP Biomedicals, LCC, Solon, OH, USA) was added in concentration of 0.5; 0.75 and 1 g/g to a collagen solution (1%, pH 7.4) prepared from the initial gel with 1 M sodium hydroxide.…”

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

“…The degree of swelling of the CCA biocomposite films in different solutions is presented in Figure 4. It can be seen that CCA biocomposite films were swelled in distilled water and in pH 2.0 and pH 7.4 buffer solutions due to the swelling of carrageenan and collagen in the films [9,27,28]. The films prepared by 3D printing method have a less compact structure as compared to those prepared by solution casting, resulting these films to absorb water more easily.…”

“…Collagen has been known as a drug carrier with many advantages such as nontoxicity, high biocompatibility, and good interactions with drugs [4,5,8,9]. Collagen has been used alone or in combination with other polymers (chitosan, polycaprolactone, carboxymethyl chitosan, hyaluronic acid, etc.)…”