Pitiriasis liquenoide y varioliforme aguda (enfermedad de Mucha-Haberman)

Gómez, M.T. Bordel; Durán, J.C. Santos; Estella, Juan Sánchez; Chaves, Mariana; Pablo, M.T. Alonso San

doi:10.1016/s1695-4033(07)70310-7

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Pitiariasis Liquenoide1

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“…Se la ha asociado a infección por VIH, Toxoplasma gondii, portación faríngea de Streptococcus, parvovirus B19, varicela zóster, entre otros. 2,3 En el caso de nuestro paciente, el resultado de las serologías reveló infección reciente por Mycoplasma.…”

Section: Pitiariasis Liquenoideunclassified

¿Cuál es su diagnóstico?

2018

Arch Argent Pediatr

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Section: Pitiariasis Liquenoideunclassified

¿Cuál es su diagnóstico?

2018

Arch Argent Pediatr

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Mucha‐Habermann disease: a pediatric case report and proposal of a risk score

et al. 2021

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Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare inflammatory dermatological disease. A case of a 13-year-old boy with FUMHD possibly triggered by mycoplasma infection is presented. Based on FUMHD cases identified in a MEDLINE literature search, demographic, treatment, and outcome data were analyzed. An FUMHD mortality risk score is proposed based on the likelihood ratios of risk factors for a fatal outcome. Our FUMHD case had marked leukopenia and thrombocytopenia at admission. He recovered without systemic immunosuppressive treatment. Literature review revealed 119 FUMHD cases. Overall lethality was 14/119 (12%, CI 6-17%), and lethality in children was lower (1/54, 2%, CI 0-6%) compared to adults (13/65, 20%, CI 11-31%). Risk factors for a fatal outcome (likelihood ratio; P) were sepsis (24.97, P < 0.001), adult vs. pediatric patient age (11.19; P = 0.001), systemic involvement (19.97, P < 0.001), and mucosal involvement (4.58; P = 0.032). The proposed FUMHD mortality risk score = Age/ 10 + 4 + 4 (if systemic involvement) + 1 (if mucosal involvement) was discriminative (sensitivity 93%, specificity 77%). In FUMHD, immune-suppressive treatment intensity should be balanced against the mortality risk, as infectious complications are a frequent cause of death.

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