Pittsburgh Registry of Infant Multiplets (PRIM)

Strassberg, Melissa; Peters, Katherine; Marazita, Mary L.; Ganger, Jennifer; Watt-Morse, Margaret; Murrelle, Lenn; Tarter, Ralph E.; Vanyukov, Michael

doi:10.1375/136905202320906363

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…The algorithm for determining zygosity has been described elsewhere. 41 It has been previously demonstrated that this short questionnaire has an accuracy of 94% for zygosity determination when compared with molecular genetic results [41,42]. All aspects of this study were approved by an Institutional Review Board (IRB).…”

Section: Methodsmentioning

confidence: 99%

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

Weinberg¹,

Parsons²,

Marazita³

et al. 2013

d3000

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Introduction Previous research suggests that aspects of facial surface morphology are heritable. Traditionally, heritability studies have used a limited set of linear distances to quantify facial morphology and often employ statistical methods poorly designed to deal with biological shape. In this preliminary report, we use a combination of 3D photogrammetry and landmark-based morphometrics to explore which aspects of face shape show the strongest evidence of heritability in a sample of twins. Methods 3D surface images were obtained from 21 twin pairs (10 monozygotic, 11 same-sex dizygotic). Thirteen 3D landmarks were collected from each facial surface and their coordinates subjected to geometric morphometric analysis. This involved superimposing the individual landmark configurations and then subjecting the resulting shape coordinates to a principal components analysis. The resulting PC scores were then used to calculate rough narrow-sense heritability estimates. Results Three principal components displayed evidence of moderate to high heritability and were associated with variation in the breadth of orbital and nasal structures, upper lip height and projection, and the vertical and forward projection of the root of the nose due to variation in the position of nasion. Conclusions Aspects of facial shape, primarily related to variation in length and breadth of central midfacial structures, were shown to demonstrate evidence of strong heritability. An improved understanding of which facial features are under strong genetic control is an important step in the identification of specific genes that underlie normal facial variation.

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Section: Methodsmentioning

confidence: 99%

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

Weinberg¹,

Parsons²,

Marazita³

et al. 2013

d3000

View full text Add to dashboard Cite

show abstract

“…Each family member independently completed anonymous paper-and-pencil questionnaires. A brief zygosity questionnaire developed by Nichols and Bilbro (1966), with the corresponding zygosity determination algorithm developed by Eley and colleagues for the Twins Early Development Study (TEDS) in London [personal communication (Strassberg et al 2002; Jenkins et al 2006)] was used for zygosity determination. The questionnaire is composed of 15 items to evaluate the similarity and differences between members of the twin pair.…”

Section: Methodsmentioning

confidence: 99%

Measurement of the Risk for Substance Use Disorders: Phenotypic and Genetic Analysis of an Index of Common Liability

et al. 2009

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The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI’s phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.

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“…Most volunteer-based registers rely on advertising to recruit participants, and this is achieved using various media outlets, referrals by health professionals, and contact through twins clubs, parishes, schools and hospitals (Baker et al, 2002;Boomsma et al, 2002b;Hayakawa et al, 2002;Hopper, 2002;Jang et al, 2002;Spector & MacGregor, 2002;Spinath et al, 2002;Strassberg et al, 2002).…”

mentioning

confidence: 99%

The Western Australian Register of Childhood Multiples: Effects of Questionnaire Design and Follow-up Protocol on Response Rates and Representativeness

Hansen¹,

Alessandri

Croft

et al. 2004

Twin Res

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Pittsburgh Registry of Infant Multiplets (PRIM)

Cited by 6 publications

References 4 publications

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

Measurement of the Risk for Substance Use Disorders: Phenotypic and Genetic Analysis of an Index of Common Liability

The Western Australian Register of Childhood Multiples: Effects of Questionnaire Design and Follow-up Protocol on Response Rates and Representativeness

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