Pituitary adenoma, primary parathyroid hyperplasia and papillary (non-medullary) thyroid carcinoma

Abstract

An acidophilic pituitary adenoma associated with primary nodular parathyroid hyperplasia and a small papillary thyroid carcinoma was discovered at the autopsy of a 44 year old female acromegalic. The thyroid carcinoma showed evidence of lymphatic spread. Several etiopathogenetic mechanisms for the non-medullary thyroid carcinomata associated with Multiple Endocrine Neoplasia (MEN) have been postulated, since the follicular epithelium of the thyroid does not belong to the neural ectoderm derivates unlike the C-cells of the thyroid, the adenohypophysis and probably the parathyroid glands. Apart from genetic influence, or coincidence, one has to rule out carcinogenic exposure or hormonal influence. Clinically speaking, one should always consider whether malignant thyroid disease coexists with hyperplastic or neoplastic parathyroid tissue.

Death from Neglected Pituitary Adenoma: A Case Report

“…Clinical presentations may range from acromegaly or gigantism [21], Cushing's syndrome [22], Nelson syndrome, hyperprolactinaemia, and other rare endocrine syndromes. Most cases are sporadic, but some occur as part of multiple endocrine neoplasia1 [23,24], or other inheritable tumour syndromes [25], and may occur with other tumours [26,27].…”

Thyroid Pathology

“…It is believed that this is likely to be a random event of location and does not indicate a casual relationship [143]. Several authors have described the association of PTC and parathyroid adenoma and/or hyperplasia [180,181]. Both types of lesions are associated with a history of low-dose external radiation to the neck.…”