Pituitary apoplexy following combination chemotherapy - a case report

Davies, John Stephen; Rees, D. A.; Evans, L. M.; Scanlon, M. F.

doi:10.1677/erc.0.0050151

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…To our knowledge, only two cases of pituitary apoplexy related to cytotoxic chemotherapy have been reported [ 4 5 ]. Pituitary apoplexy was reported in the second cycle of cisplatin, methotrexate, and vinblastine chemotherapy in a 70-year-old man with penile squamous cell carcinoma [ 5 ]. The patient had sudden, severe headache and diplopia due to left third-nerve palsy.…”

Section: Discussionmentioning

confidence: 99%

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Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer

Jang

Hong

et al. 2018

Brain Tumor Res Treat

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Surgery, anticoagulation therapy, pregnancy, and hormone treatments, such as bromocriptine, are well-characterized precipitating factors for pituitary apoplexy. However, whether cytotoxic chemotherapy for systemic cancer could cause pituitary apoplexy has not been investigated. Here, we present a case of a 41-year-old woman who developed a severe headache with decreased visual acuity after intravenous cytotoxic chemotherapy to treat metastatic breast cancer. Preoperative neuroimaging revealed pituitary adenoma with necrosis. Operative findings and pathologic examination concluded extensive necrosis with a small intratumoral hemorrhage in a pre-existing pituitary adenoma. We reviewed two additional previously published cases of pituitary apoplexy after systemic chemotherapy and suggest that cytotoxic chemotherapy may induce pituitary apoplexy.

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Section: Discussionmentioning

confidence: 99%

“…Most cases of pituitary apoplexy occur in the absence of any precipitating factor. Cytotoxic chemotherapy for systemic cancer has not been considered as a cause of apoplexy; however, there have been two previously reported cases of pituitary apoplexy following systemic chemotherapy [ 4 5 ].…”

Section: Introductionmentioning

confidence: 99%

Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer

Jang

Hong

et al. 2018

Brain Tumor Res Treat

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“…To our knowledge, there are only four other cases of PA associated with the administration of systemic chemotherapies [ 4 - 7 ] (Table 1 ). Consistent with the broad epidemiology of PA in general, these prior reports include two male and two female patients who ranged in age from 41 to 70 years.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there have been only four prior case reports of PA temporally associated with the administration of systemic chemotherapy [ 4 - 7 ]. We add to this literature by reporting the case of a patient who experienced PA one week after initiation of chemotherapy for metastatic testicular cancer.…”

Section: Introductionmentioning

confidence: 99%

Pituitary Apoplexy Precipitated by Systemic Chemotherapy

Hamrick¹,

Findlay²,

Rennert³

et al. 2022

Cureus

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Pituitary apoplexy often occurs in patients with previously undiagnosed pituitary adenomas and no predisposing factors. Among patients with precipitating events, there are very few cases of pituitary apoplexy occurring in the setting of systemic chemotherapy treatment. A 31-year-old man with newly diagnosed metastatic testicular cancer developed headaches, nausea, and a right-sided visual field deficit one week after initiation of bleomycin, etoposide, and cisplatin chemotherapy. Computed tomography and magnetic resonance imaging revealed hemorrhage within a pituitary macroadenoma consistent with pituitary apoplexy, and he underwent urgent transnasal resection. We also review the four prior cases of pituitary apoplexy temporally associated with the administration of systemic chemotherapy.

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