Pituitary Diseases and Bone

Mazziotti, Gherardo; Chiavistelli, Silvia; Giustina, Andrea

doi:10.1016/j.ecl.2014.10.014

Cited by 50 publications

(42 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Treatment of GHD with GH increases vertebral and femoral BMD over time. Recombinant human GH has a biphasic effect on bone; an initial phase associated with an increase in bone resorption and a decrease in BMD and a second phase characterized by an increase in bone formation and in BMD, usually after six to twelve months of treatment (109) .…”

Section: Introductionmentioning

confidence: 99%

“…Acromegaly is associated with increased bone remodeling, and patients with acromegaly have a significantly higher prevalence of vertebral fractures, which correlate with the duration of the disease and serum IGF-1 levels (109, 110) . Radiological vertebral fractures occur in as many as a third of the patients with acromegaly without changes in BMD, so that BMD has limited value in the assessment of these patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

Mirza

Canalis

2015

European Journal of Endocrinology

267

164

View full text Add to dashboard Cite

Osteoporosis is a skeletal disorder characterized by decreased bone mineral density and compromised bone strength predisposing to an increased risk of fractures. Although idiopathic osteoporosis is the most common form of osteoporosis, secondary factors may contribute to the bone loss and increased fracture risk in patients presenting with fragility fractures or osteoporosis. Several medical conditions and medications significantly increase the risk for bone loss and skeletal fragility. This review focuses on some of the common causes of osteoporosis, addressing the underlying mechanisms, diagnostic approach and treatment of low bone mass in the presence of these conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

Mirza

Canalis

2015

European Journal of Endocrinology

267

164

View full text Add to dashboard Cite

show abstract

“…Because only about one-third of VFs are clinically recognized [16], the radiological and morphometric approach has emerged as the method of choice for evaluating the true prevalence and incidence of these fractures in population and clinical studies [19]. Different from other pituitary diseases [20], VFs have not been so far investigated in patients with TSH-oma.…”

mentioning

confidence: 99%

High Prevalence of Radiological Vertebral Fractures in Patients With TSH-Secreting Pituitary Adenoma

Frara

Losa

Doga

et al. 2018

Journal of the Endocrine Society

Self Cite

View full text Add to dashboard Cite

BackgroundBone loss and high risk of fractures have been reported in patients with primary hyperthyroidism, whereas data on skeletal health in TSH-secreting adenoma (TSH-oma) are scant, and the risk of fractures in this specific clinical context has not been investigated so far. In this cross-sectional study, we aimed at evaluating for the first time, to our knowledge, the prevalence and determinants of radiological vertebral fractures (VFs) in patients with TSH-oma.MethodsTwenty-two patients (10 males, 12 females; median age 47 years) with TSH-oma and 44 patients (20 males, 24 females; median age 49 years) with nonfunctioning pituitary adenoma (NFPA) were retrospectively evaluated for thoracic VFs using a morphometric approach on lateral chest X-ray routinely performed in the presurgical diagnostic workup.ResultsThe prevalence of VFs was significantly higher in TSH-oma vs NFPA (59.1% vs 22.7%; P = 0.003), the difference being still significant (odds ratio, 10.5; P = 0.005) after correction for the size of pituitary adenomas and biochemical parameters. In TSH-oma, the prevalence of VFs was significantly associated with older age (P = 0.007) and higher serum free T4 values (P = 0.02). In 20 patients, data on presurgical medical therapies of TSH-oma were available. All patients not treated with somatostatin receptor ligands were fractured compared with 25% of those who were treated with these drugs (P = 0.001). No significant (P = 0.25) association between VFs and treatment with methimazole was found.ConclusionsThis study provides the first evidence, to our knowledge, that patients with TSH-oma may develop VFs in close relationship with severity of hyperthyroidism.

show abstract

“…Several lines of evidence, including in vitro, experimental and clinical studies, support the direct relevance of the GH and insulin-like growth factor 1 (IGF-1) axis in skeletal physiology [7]. Lack of GH leads to decreased bone turnover and decreased bone mineral density (BMD) in patients with GH deficiency of adult onset [7]. Whether GH deficiency of childhood onset is similarly associated with decreased BMD in adult life is controversial [8].…”

mentioning

confidence: 99%

“…In addition to GH deficiency, these patients may often have other hormone deficiencies, which may influence bone health, either directly (hypogonadism) or indirectly as a consequence of excess replacement therapies (hypoadrenalism and hypothyroidism) [7]. Several lines of evidence, including in vitro, experimental and clinical studies, support the direct relevance of the GH and insulin-like growth factor 1 (IGF-1) axis in skeletal physiology [7]. Lack of GH leads to decreased bone turnover and decreased bone mineral density (BMD) in patients with GH deficiency of adult onset [7].…”

mentioning

confidence: 99%

Skeletal health in adult growth hormone deficiency

Tritos

2016

Endocrine

View full text Add to dashboard Cite

Pituitary Diseases and Bone

Cited by 50 publications

References 50 publications

MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

High Prevalence of Radiological Vertebral Fractures in Patients With TSH-Secreting Pituitary Adenoma

Skeletal health in adult growth hormone deficiency

Contact Info

Product

Resources

About