Pituitary disorders and osteoporosis

Bolanowski, Marek

doi:10.1530/endoabs.35.mte10

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Hypercortisolism affects bone metabolism with various mechanisms. It is known that glucocorticoid excess inhibits bone formation, reduces the replication of bone forming cells, prevents the differentiation of osteoblasts, induces apoptosis of osteoblasts by activating caspase 3 and inhibits collagen type I synthesis [54]. Treatment of pituitary hormone excess such as surgery of pituitary adenomas improve skeletal health in some patients, whereas others seem to remain a high risk of fractures.…”

Section: Cushing's Syndrome and Sarcopenic Obesitymentioning

confidence: 99%

Sarcopenia – Endocrinological and Neurological Aspects

Stangl

Böcker²,

Chubanov³

et al. 2018

Exp Clin Endocrinol Diabetes

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Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance. These patients are typically younger and suffer from conditions caused by a known molecular disease mechanism and a peculiar sarcopenic phenotype. Therefore, these sequelae can serve as prototypic disease models to study isolated endocrinological and neurodegenerative causes for sarcopenia. This review focuses on diseases whose etiopathogenesis of muscle impairment is known. The idea is to use these diseases as proof of principles to develop a classification algorithm of sarcopenia in the elderly to make a more mechanism-oriented therapy be possible.

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Section: Cushing's Syndrome and Sarcopenic Obesitymentioning

confidence: 99%

Sarcopenia – Endocrinological and Neurological Aspects

Stangl

Böcker²,

Chubanov³

et al. 2018

Exp Clin Endocrinol Diabetes

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“…Повышение уровня ПРЛ часто ассоциировано с увеличением массы тела, что подтверждено в ряде исследований [11][12][13]. В настоящее время известно, что ПРЛ влияет на обмен костной ткани, а также водноэлектролитный, липидный и углеводный обмен [14][15][16][17]. Наряду с влиянием ПРЛ на массу тела представляет интерес его влияние на липидный состав крови.…”

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Особенности Липидного Обмена У Больных С Пролактиномами На Этапах Супрессивной Терапии Агонистами Дофамина

Hohitidze¹

2021

Mìžnarodnij endokrinologìčnij žurnal

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The article presents the data of lipid metabolism at the stages of long-term (12 months) suppressive therapy with dopamine agonist cabergoline in 61 patients with prolactinoma. It is proved that the normalization of prolactin levels during therapy reduces the risk of development and progression of atherogenesis through reduction of total cholesterol content and increase in high-density lipoprotein cholesterol. Suppressive pharmacotherapy with cabergoline reduces the total cholesterol level in both men and women. Men had most pronounced improvement in the ratio of pro-and antiatherogenic lipid fractions.

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“…La enfermedad presenta diversas y frecuentes comorbilidades producto de la afectación sistémica; 25 al 50 % de los pacientes muestran alteración en el metabolismo de los carbohidratos 2 , 18 al 60% presentan hipertensión arterial crónica 5 , 30% poseen afectación cardiaca [6][7][8][9] (20% dilatación biventricular y 10% insuficiencia cardiaca congestiva), 4% presenta enfermedad tiroidea 11 y 20 % presentan osteoporosis u osteoartritis [12][13] . Además, estos pacientes tienen un mayor riesgo de desarrollar panhipopituitarismo.…”

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