Pituitary Function Assessment in Short Stature by a Combined Hormonal-Stimulation Test

Pugliese, M; Lifshitz, Fima; Fort, Pavel; Cervantes, Cecilia; Recker, Bridget; Ginsberg, L

doi:10.1001/archpedi.1987.04460050098040

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Two venous cannulas were placed in the forearms: one for infusion of arginine and insulin, and one for blood sampling. The AITT followed the standard procedure used to study growth hormone (GH) secretion and hypoglycaemic stress response 12. After an overnight fast, an intravenous arginine infusion (0.5 mg/kg body weight over 30 minutes) was given at 08:30 and insulin (0.10 U/kg) was given one hour later as an intravenous bolus injection.…”

Section: Methodsmentioning

confidence: 99%

Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue

Kamel

Norgren

Persson

et al. 1999

Archives of Disease in Childhood

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Aims-To investigate the dynamics between plasma and dialysate glucose during hypoglycaemia in children. Study design-Six children in prepuberty or early puberty were investigated by multiple blood sampling and microdialysis of subcutaneous adipose tissue during a standard arginine-insulin tolerance test. Glucose and glycerol, as an index of lipolysis, were measured in samples from both compartments. Plasma concentrations of insulin and the main counterregulatory hormones were also measured. Results-Plasma and dialysate glucose concentrations were very similar at baseline and increased in concert after infusion of arginine, probably in response to glucagon release. After insulin injection, glucose in both plasma and dialysate fell in parallel. The subsequent hypoglycaemic stress response induced a rapid rebound in the plasma concentration with a mean (SD) delay in the dialysate of 16 (3) minutes. Plasma glycerol was approximately fivefold lower than in the dialysate and did not fluctuate significantly. Dialysate glycerol decreased with arginine infusion and reached a nadir immediately following insulin administration. Subsequently, the antilipolytic eVect of insulin was overcome by the hypoglycaemic stress response, and lipolysis prevailed in spite of hyperinsulinaemia. Conclusion-After rapidly induced hypoglycaemia, rebound of interstitial glucose concentrations is significantly delayed compared with plasma concentrations, and the antilipolytic eVect of hyperinsulinaemia is opposed possibly by the hypoglycaemic stress response. (Arch Dis Child 1999;80:42-45)

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Section: Methodsmentioning

confidence: 99%

Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue

Kamel

Norgren

Persson

et al. 1999

Archives of Disease in Childhood

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Body Weight Progression and Nutritional Status of Patients With Familial Short Stature With and Without Constitutional Delay in Growth

Solans

Lifshitz²

1992

Arch Pediatr Adolesc Med

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Hypothalamic-pituitary function assessment in children by a combined stimulation test

Cong

Jiang

Wang

et al. 1992

Journal of Tongji Medical University

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We utilized a combined stimulation test using insulin, thyrotropin-releasing hormone, gonadotropin-releasing hormone and levodopa to assess multiple pituitary hormones including growth hormone, thyrotropin, prolactin and gonadotropins in 32 children of short stature and 18 girls with early appearance of puberty. It was found that this combined stimulation test can assess multiple hormone responses with satisfactory results in a single 90-min test. Compared with any of those laborious classic stimulation tests alone, it is easier to be carried out and willingly accepted by children.

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Pituitary Function Assessment in Short Stature by a Combined Hormonal-Stimulation Test

Cited by 4 publications

References 19 publications

Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue

Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue

Body Weight Progression and Nutritional Status of Patients With Familial Short Stature With and Without Constitutional Delay in Growth

Hypothalamic-pituitary function assessment in children by a combined stimulation test

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