Pituitary luteinising and follicle-stimulating hormones

Bishop, William H.; Nureddin, Aida; Ryan, Robert J.

doi:10.1007/978-1-349-02718-7_14

Cited by 6 publications

(4 citation statements)

References 119 publications

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“…The biological effects of these polypeptides are different despite extensive sequence homologies of their subunits. They undergo post-translational glycosylation after assembly of the α and β-subunits [45][46][47][48].…”

Section: Glycoprotein Hormonesmentioning

confidence: 99%

Hormones

Sandow¹,

Scheiffele²,

Haring³

et al. 2000

Ullmann's Encyclopedia of Industrial Chemistry

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Section: Glycoprotein Hormonesmentioning

confidence: 99%

Hormones

Sandow¹,

Scheiffele²,

Haring³

et al. 2000

Ullmann's Encyclopedia of Industrial Chemistry

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“…The α-subunit is essentially identical to the α-subunits of follicle stimulating hormone (FSH, follitropin), thyroid stimulating hormone (TSH, thyrotropin), and human chorionic gonadotropin (hCG) [5][6][7][8]. The β-subunit is considerably different from that of FSH and TSH [5,8,9]. However, the β-subunits of LH and hCG are very similar [5,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The β-subunit is considerably different from that of FSH and TSH [5,8,9]. However, the β-subunits of LH and hCG are very similar [5,9,10]. LH, together with FSH, is secreted by the gonadotroph cells in the pituitary [9,11] in response to the secretion of the gonadotropin releasing hormone from the medial basal hypothalamus [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…However, the β-subunits of LH and hCG are very similar [5,9,10]. LH, together with FSH, is secreted by the gonadotroph cells in the pituitary [9,11] in response to the secretion of the gonadotropin releasing hormone from the medial basal hypothalamus [12][13][14]. Ovarian steroids, principally estrogens, modulate the secretion of LH and FSH which in turn regulate the menstrual cycle in females.…”

Section: Introductionmentioning

confidence: 99%

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Performance Evaluation of an Improved ARCHITECT LH Assay for the Quantitative Determination of Luteinizing Hormone in Human Serum and Plasma

Oer¹,

Beckert²,

Heinrich³

et al. 2012

BIO

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Determination of the concentration of human luteinizing hormone plays an important role for the prediction of ovulation, evaluation of infertility, diagnosis of pituitary and gonadal disorders and in the differential diagnosis of puberty disorders. The ARCHITECT LH chemiluminescent-immunoassay for the quantitative determination of luteinizing hormone in human serum and plasma serves this clinical utility. The assay was redesigned to improve robustness in terms of better lot-to-lot consistency, allowing users to discontinue current practice of matching reagent, calibrators and controls. The redesigned ARCHITECT LH assay was evaluated on the ARCHITECT instrument-platform and compared to the predicate device: the previously marketed ARCHITECT LH assay. Total imprecision of the assay was 2.4-8.9%CV across the claimed measuring interval (0.09-250.00 mIU/mL). Detection Limits were determined as Limit of Quantitation with 0.09 mIU/mL, Limit of Blank 0.01 mIU/mL and Limit of Detection 0.03 mIU/mL. Correlation slope to the predicate ARCHITECT LH assay was 1.04. Linearity was demonstrated in the claimed measuring interval. Mean recovery was determined to be 101.0 %. Process capability indices demonstrated excellent (>6 Sigma) lot-to-lot reproducibility. The redesigned ARCHITECT LH assay showed excellent performance and good correlation to the predicate device. The high lot-to-lot reproducibility demonstrates excellent process capability and allows more flexibility in managing inventory for end-users. Matching of reagents, calibrators and controls is no longer required. The ARCHITECT LH assay is a valuable tool in clinical laboratories for the accurate and precise quantitation of human luteinizing hormone.

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Hormones, 1. Hormone Systems

Sandow¹

2011

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 1.1. Definitions and Classification 1.2. Hormone‐Producing Systems 1.3. Structural Analysis and Synthesis 1.4. Receptors and Mechanisms of Action 1.5. Therapeutic Use of Hormones 2. Peptide and Protein Hormones 2.1. Hypothalamic Hormones 2.2. Proopiomelanocortin Hormones 2.3. Glycoprotein Hormones 2.4. Growth Hormone, Prolactin, and Placental Lactogen 2.5. Calcium‐Regulating Hormones 2.6. Glucose‐Regulating Hormones 2.7. Gastrointestinal Hormones 2.8. Growth Factors and Related Peptides 2.9. Cardiovascular Hormones 3. Amino Acid Derivatives 3.1. Catecholamines and Indolamines 3.2. Thyroid Hormones 3.3. Thyromimetics 4. Steroid Hormones 4.1. Estrogens, Gestagens 4.2. Androgens 4.3. Adrenal Steroids 5. Prostaglandins 6. Hormone Analogs and Antagonists

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Pituitary luteinising and follicle-stimulating hormones

Cited by 6 publications

References 119 publications

Hormones

Hormones

Performance Evaluation of an Improved ARCHITECT LH Assay for the Quantitative Determination of Luteinizing Hormone in Human Serum and Plasma

Hormones, 1. Hormone Systems

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