Pityriasis lichenoides: Long‐term follow‐up study

Zang, Julie B.; Coates, Sarah J.; Huang, Jin; Vonderheid, Eric C.; Cohen, Bernard A.

doi:10.1111/pde.13396

Cited by 21 publications

(21 citation statements)

References 25 publications

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“…50 Only some studies compared treatment responses of patients with PL in a long-term follow-up to assess how are durable the results after the cessation of treatment. Zang et al 51 reviewed treatment responses of 75 children with PL (50 PLC and 25 PLEVA) and conducted a long-term follow-up via telephone interviews but did not report relapse rates for each treatment. There were no differences in terms of response to treatment between patients with PLC and PLEVA.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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Section: Discussionmentioning

confidence: 99%

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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“…Pityriasis lichenoides chronica (PLC) is a chronic inflammatory skin disorder of unknown etiology (Maranda et al, 2016). It is considered a therapeutic challenge because of its frequently relapsing course (Zang et al, 2018). Clinical and therapeutic information of cutaneous inflammatory disorders in dark skin, including PLC, is scarce (Charrow et al, 2017).…”

Section: Dear Editormentioning

confidence: 99%

“…Nineteen Hispanic patients with PLC were included. Clinical and demographic characteristics are shown in Table 1 (Maranda et al, 2016;Zang et al, 2018). Currently, data regarding the role of skin phototype in the clinical response to NB-UVB phototherapy is contradictory.…”

Section: Dear Editormentioning

confidence: 99%

Efficacy of phototherapy in pityriasis lichenoides chronica of dark skin: A retrospective study from a tertiary center in Mexico

Cuéllar-Barboza

Garza

Villarreal-Villarreal

et al. 2018

Dermatologic Therapy

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“…PLEVA). Poznato je da PL tri puta češće zahvaća muškarce nego žene i da se PLEVA pojavljuje šest puta rjeđe od PLC-a, no uzrok ovih razlika u pojavnosti i točna prevalencija PLEVA-e u općoj populaciji nisu poznati 1,2 . PLE-VA ili Mucha-Habermannova bolest rijetka je idiopatska stečena dermatoza obilježena eritematoskvamoznim papulama, često popraćenim hemoragičnim, papulovezikularnim i papulonekrotičnim lezijama s varioliformnim ožiljkavanjem.…”

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Uspješno liječenje pityriasis lichenoides et varioliformis acuta u pacijenta s kroničnom hiperuricemijom

Gašparini

Kaštelan

2019

Med. Flum. (Online)

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Sažetak. Cilj: Prikazati slučaj pacijenta s pityriasis lichenoides et varioliformis acuta, s predstavljanjem dijagnostičkih i terapijskih izazova ovog kliničkog entiteta. Prikaz slučaja: Tridesetogodišnji pacijent upućen je na Kliniku za dermatovenerologiju zbog kožnih promjena popraćenih svrbežom u trajanju od mjesec i pol dana. Crvene papule i papulokruste bile su prisutne na trupu, gornjim i donjim ekstremitetima, no na gornjim i donjim ekstremitetima bile su brojnije i jače izražene nego na trupu. Pacijent je naveo da je povremeno uzimao febuksostate za liječenje kronične hiperuricemije tijekom posljednje četiri godine. Započeta je lokalna terapija kombinacijom betametazona i gentamicina te peroralnim desloratadinom. U krvnoj slici uočene su neutropenija, povišene vrijednosti kolesterola lipoproteina niske gustoće i povišene vrijednosti urata. Učinjena je biopsija kožne promjene, a pacijentu je preporučen doksiciklin uz nastavak liječenja betametazonom i gentamicinom. Patohistološki nalaz opisivao je ulcerirani epidermis s edemom, granulacijskim tkivom i ekstravazacijom eritrocita u dnu ulceracije. Prema bazi ulceracije i subepidermalno nalazili su se infiltrati limfocita i histiocita, a epidermis je na rubovima ulceracije bio nepravilno hiperplastičan s izraženom spongiozom. Time je potvrđena dijagnoza pityriasis lichenoides et varioliformis acuta. Po završetku liječenja doksiciklinom došlo je do potpune regresije kožnih promjena i sniženja vrijednosti urata. Zaključci: U pacijenata s dijagnozom pityriasis lichenoides et varioliformis acuta potreban je povećan oprez u dijagnosticiranju i liječenju te redovito praćenje stanja zbog širokog spektra diferencijalnih dijagnoza i mogućnosti postavljanja krive dijagnoze. Nužna su daljnja istraživanja o etiopatogenetskoj osnovi ove bolesti s ciljem upotrebe tih znanja u uspješnijem liječenju. Abstract. Aim: To report a case of a patient with pityriasis lichenoides et varioliformis acuta, emphasising the challenges in the diagnosis and treatment of this clinical entity. Case report:A 30-year-old patient was referred to the Department of Dermatology and Venereology due to skin changes accompanied by itching persisting for one and a half month. Red papules and papulocrusts were found on the trunk, upper and lower limbs, but in a larger number and more severely affecting the trunk than the limbs. The patient stated the occasional use of febuxostat for the treatment of chronic hyperuricemia that has been diagnosed four years prior. Treatment with desloratadine and a combination of bethametasone and gentamicin was started. The laboratory results showed neutropenia, high levels of low density lipoprotein cholesterol and high levels of urate. The biopsy of the skin lesion has been done. Doxycycline treatment and continuing treatment with bethametasone and gentamicin were recommended to the patient. Pathohistological finding described ulcerated epidermis with oedema, granulation tissue and erythrocyte extravasation in the floor of the ulceration. Lymphocytic and histiocytic i...

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Pityriasis lichenoides: Long‐term follow‐up study

Cited by 21 publications

References 25 publications

A systematic review of treatments for pityriasis lichenoides

A systematic review of treatments for pityriasis lichenoides

Efficacy of phototherapy in pityriasis lichenoides chronica of dark skin: A retrospective study from a tertiary center in Mexico

Uspješno liječenje pityriasis lichenoides et varioliformis acuta u pacijenta s kroničnom hiperuricemijom

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