Pityriasis Lichenoids Chronica as a Paraneoplastic Dermatosis for Primary Splenic Diffuse Large B Cell Lymphoma

Abstract

Paraneoplastic dermatosis is defined as both benign skin lesions and internal malignancy existing at the same time with parallel clinical courses. Herein, we report a 91-year-old male who presented as pityriasis lichenoids chronica (PLC) concomitantly with a primary splenic diffuse large B cell lymphoma. Surgical removal of the spleen cleared his skin lesions dramatically. However, seven months later, the splenic lymphoma relapsed in concordance with the recurrence of the skin lesions of PLC. To our knowledge, he is the first case that PLC is the leading presentation and paraneoplastic manifestation of primary splenic large B-cell lymphoma.

Pityriasis lichenoides chronica in a patient on tafasitamab and lenalidomide therapy for diffuse large B-cell lymphoma

“…1 More rarely, PLC may be seen as a paraneoplastic phenomenon or a reaction to a medication. 3 , 4 Some researchers label PLC as a lymphoproliferative disorder given that these patients have demonstrated T-cell clonality, but this is highly debated in the literature. 1 , 2 , 5 Herein, we present a case of PLC in a patient with diffuse large B-cell lymphoma (DLBCL) who developed a rash after initiating tafasitamab/lenalidomide therapy.…”