Pityriasis rotunda. A cutaneous sign of malignant disease in two patients

Leibowitz, Michael R.; Weiß, Robert M.; Smith, Eric H.

doi:10.1001/archderm.119.7.607

Cited by 29 publications

(17 citation statements)

References 2 publications

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“…There is however little practical purpose in distinguishing between the two types since both may be found in different parts of the same tumor and the clinical course are similar. Skin features documented with PLCC include cutaneous porphyria [7,8], pityriasis rotunda [9,10], papules and nodules to the skin from metastasis [11,12]. Some features found in this study point to possible underlying or background liver cirrhosis (LC) before the transformation to malignancy.…”

Section: Discussionmentioning

confidence: 70%

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

George¹,

Otegbayo²,

Ogunbiyi³

et al. 2008

African Journal of Health Sciences

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SUMMARYPrimary liver cell carcinoma (PLCC), predominantly hepatocellular carcinoma is a killer. In the southwestern region of Nigeria it occupies the second position, behind prostate cancer in males. Females account for about a third of diagnosed cases. Children are not spared. Over 80 % of PLCC cases present to the hospital at an advanced stage in Nigeria and some die within weeks of admission to the wards. A prospective hospital based study was carried out to determine muco-cutaneoeus features associated with the entity as a possible aid to diagnosis cutaneous features being considered a cheap tool that can help diagnosis in a developing country-at an affordable cost. 80 of 84 patients seen during the study period had data that were adequate for analysis. The age range was 18-76 years with a mean of 56.2 years. The male female ratio was 17:3 indicating that males remain the more affected gender. No skin feature was found to be specific to PLCC. Jaundice (63.75 %), pallor 43.75 %), peripheral oedema (32.50 %), palmoplantar macular hyperpigmentation (47.5 %/25.0% -plantar /palmar) however were the common features documented in the study. Moderate to severe pityriasis versicolor was found in 18.75 % of cases. 61.25 % had core temperature less than 36 0 C. Amongst non-cutaneous features found on examination, right sided upper abdominal pain/discomfort and swelling were common. While none of the features documented in this study are specific to PLCC (and most are likely related to underlying liver cirrhosis) it may be helpful to realize that Jaundice and marked palmoplantar macular pigmentation, the complaint of pain /mass, and the presence of a tender nodular mass in the right hypochondrium should make one to consider the localization of the disease to the liver. Pain/tenderness in the right hypochondrium suggest rapid growth of the liver from increased mitosis in the hepatocytes and a stretching of the liver capsule. Metastasis to the liver accounts for a very small percentage in Nigerians. A nodular liver is thus likely to be from a primary liver pathology.

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Section: Discussionmentioning

confidence: 70%

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

George¹,

Otegbayo²,

Ogunbiyi³

et al. 2008

African Journal of Health Sciences

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“…Yap›lan bas›l› materyal ve online veri taramas›nda ülkemizden bildirilen bir olguya rastlanmam›flt›r. PR'n›n etyolojisi bilinmemekle birlikte genetik predispozisyon, malnutrisyon, infeksiyonlarla ve malinite ile iliflkisi bildirilmifltir 8,14 . Morfolojik olarak lezyonlar›n yüzeyel yerleflimi ve eritemin periferde daha belirgin olmas› nedeniyle tinea korporise benzerlik gösterir, ancak yap›lan tetkiklerde etken gösterilme-mifltir 10 .…”

Section: Tart›flmaunclassified

Pityriasis Rotunda

Gençoğlan¹,

Karaarslan²,

Kazandi³

et al. 2010

turkderm

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ÖzetPitriyazis rotunda (PR), gövde ve ekstremitelerde yuvarlak-oval yamalarla karakterize nadir bir deri hastal›¤›d›r. ‹nce skuaml› bu yamalar genellikle çevredeki deriden daha aç›k renkli, bazen de daha koyu renktedir. Beyaz ›rkta oldukça nadir olan klinik tablo Japonlar, Güney Afrika ve Bat› Hindistan zencilerinde daha s›k gözlenmektedir. Akdeniz bölgesinde yo¤un olarak Sardunya adas›ndan olgular bildirilmifl olmakla birlikte Avrupa'da çok nadir görülmektedir. Burada ülkemizden tan› alan ilk iki olgu sunulmaktad›r. On befl yafl›nda k›z ve 4 yafl›nda erkek çocukta gövdenin tamam› ile ekstremitelerin proksimal k›s›mlar›n-da iyi s›n›rl›, dairesel, pitriyazik skuaml› merkezi hipopigmente, periferi eritematöz plaklar mevcuttu. Hastalar›n deri foto tipi II idi. Histopatolojik incelemede granüler tabaka izlenmedi sadece orta derecede kompakt hiperkeratoz mevcuttu. Yaln›z emolient kullan›lan hastalarda lezyonlarda tam silinme sa¤land›. (Türkderm 2010; 44: 99-101) Anahtar Kelimeler: Pitriyazis rotunda, iktiyozis SummaryPityriasis rotunda is a rare skin disease characterized by round or oval patches, localized mainly on the trunk, arms, and legs. The patches are usually lighter than the surrounding skin, but sometimes may be darker, and are covered by fine, adherent scales. It is very rare in caucasoids, common in Japanese and is also seen in South African blacks and West Indian black and Mediterrean area predominantly in Sardinia have been reported but it is seldom observed in Europe. We present the first two cases diagnosed from Turkey. There were well-demarcated circumscribed scaly plaques with a erythematous periphery and hypopigmented center on the trunk and proximal parts of upper limbs. Their skin phototype was III. Histopathologic examination revealed a moderate degree of compact hyperkeratosis without a granular layer. Complete clearing was observed with only emollients. (Turkderm 2010; 44: 99-101)

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“…Pityriasis rotunda (PR) is a rare disease characterized by perfectly round or oval, sharply defined, scaly, hypo-or hyperpigmented patches of variable number and size located mainly over the trunk and proximal extremities. It has a predilection for populations of some ethnic origins; >95% of the reported cases in literature have been from three countries/ethnic populations, namely Japan (1,2), South Africa (Bantu) (3)(4)(5), and Italy (Sardinian Islanders) (6)(7)(8)(9). Other countries/ethnic populations with reported cases of PR include the West Indies (Negro) (10), Korea (11), Manchuria (11), USA (Blacks) (12), Britain (Blacks) (10), Israel (13,14), Egypt (15), Portugal (Blacks) (16), and Tanzania (17).…”

Section: Introductionmentioning

confidence: 99%

“…, cirrhosis of the liver(18), dysentery (18) hepatocellular carcinoma(4,17), squamous cell carcinoma (8) esophageal carcinoma(8), stomach car-51 Hypopigmented, dry scaly, well-defined, round to oval patches of Pityriasis rotunda. Note confluence of the lesions in the groin and axillae, giving it the appearance of tinea /erythrasma.…”

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confidence: 99%

Pityriasis Rotunda Mimicking Tinea Cruris/Corporis and Erythrasma in an Indian Patient

Gupta

2001

The Journal of Dermatology

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Pityriasis rotunda is a rare disease characterized by perfectly round to oval, sharply defined, scaly, hypo/hyperpigmented patches of variable number and size located mainly over the trunk and proximal extremities. More than 95% of the reported cases in medical literature are from three countries/ethnic populations, namely Japan, South Africa (Bantu), and Italy (Sardinian islanders). To the best of my knowledge, no patient with the characteristic clinico-pathologic features has been reported from the Indian subcontinent. I report a 44-year-old man with eighteen pityriasis rotunda patches, persistent for nearly 20 years. The lesions in the groin and axillae closely resembled erythrasma and tinea, and he had received treatment for these conditions several times in the past. Histopathology of the skin biopsy showed thinning of the epidermis with a thinned-out granular layer and a sparse lymphomononuclear infiltrate in the dermis. A review of literature suggests that there are two subsets of the disease. The type I subset is comprised of pityriasis rotunda associated with systemic illness and is seen in Black or Oriental patients with no family history of the disease. The lesions tend to subside on treatment of the underlying illness. The type II subset patients are Caucasians as well as Blacks and Orientals with no underlying systemic illness. Familial occurrence is possible; lesions tend to be persistent and unresponsive to therapy.

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Pityriasis rotunda. A cutaneous sign of malignant disease in two patients

Cited by 29 publications

References 2 publications

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

Pityriasis Rotunda

Pityriasis Rotunda Mimicking Tinea Cruris/Corporis and Erythrasma in an Indian Patient

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