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Summary.-Seventy patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP).The complete remission rate of 75-7 % compares well with that produced by other combinations. The combination is non-toxic, easily administered and can be given safely to outpatients. Its main advantage is that it is far less upsetting to patients than combinations containing nitrogen mustard.

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The term pityriasis rotunda refers to strikingly circular scaly lesions, with the histologic appearance of ichthyosis vulgaris. Pityriasis rotunda has been described in the Japanese, South African blacks, and West Indian blacks. The condition occurs only in association with certain serious systemic illnesses, usually tuberculosis, or malignant neoplasms or less severe diseases of the female genital tract (eg, fibroids, ovarian cyst). We describe two South African blacks with pityriasis rotunda and neoplasms. The cutaneous lesions cleared when the primary neoplasm was treated.

To correlate neuroer~docrine changes with clinical response, 4 girls (4-7 yrs) and 1 boy age 6 with central precocious puberty were treamd with D-His-A subcutaneously. D-His-A was given at a dose of 4 pglkglday for 4 mos; then, the dose was increased to 8 pglkglday. The children were serially studied at 0, 3, and 6 mos. Blood was analyzed for GH, LH, FSH q 20 min (1800-0600). GnRH (2.5 pglkg IV) tests and response to D-His-A (usual treatment dose sc) were followed. Gonadal steroids fell to prepubertal range in the first 3 mos. Results of mean growth velocity (GV), GH. Somatomedin C, LH and FSH, GnRH and D-His-A Tests are shown: Pretherapy 3 mos. 6 mos.