2024
DOI: 10.3390/ijms25126778
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Pivotal Role of mTOR in Non-Skin Manifestations of Psoriasis

Ka Joo,
Claudio Karsulovic,
Milisa Sore
et al.

Abstract: Psoriasis is a chronic inflammatory condition affecting 2% of the Western population. It includes diverse manifestations influenced by genetic predisposition, environmental factors, and immune status. The sustained activation of mTOR is a key element in psoriasis pathogenesis, leading to an uncontrolled proliferation of cytokines. Furthermore, mTOR activation has been linked with the transition from psoriasis to non-skin manifestations such as psoriatic arthritis and cardiovascular events. While therapies targ… Show more

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