PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier

Li, Jingyan; Sabliov, Cristina M.

doi:10.1515/ntrev-2012-0084

Cited by 74 publications

(32 citation statements)

References 43 publications

(172 reference statements)

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“…We also tested QDs-loaded PLGA particles (PLGA 3-QD) to identify how zeta potential affects cellular uptake of particles. The behavior of cellular uptake assessed by fluorescence microscopy and flow cytometry indicated that the uptake of FPN 3-QD was inferior to that of PLGA 3-QD which is possibly correlated with the higher degree of negative zeta potential and hydrophilicity of FPN 3-DTX [53,54]. Without DTX drug loading, it was found that FPN-3 displayed high biocompatibility in the absence of DTX compared to the PLGA-3.…”

Section: Discussionmentioning

confidence: 97%

Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

et al. 2020

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Fucoidan, a natural sulfated polysaccharide, which can activate the immune response and lessen adverse effects, is expected to be an adjuvant agent in combination with chemotherapy. Using natural hydrophilic anticancer polysaccharides to simultaneously encapsulate hydrophobic anticancer drugs is feasible, and a reduced side effect can be achieved to amplify the therapeutic efficacy. In this study, a novel type of fucoidan-PLGA nanocarrier (FPN-DTX) was developed for the encapsulation of the hydrophobic anticancer drug, docetaxel (DTX), as a drug delivery system. From the comparison between FPN-DTX and the PLGA particles without fucoidan (PLGA-DTX), FPNs–DTX with fucoidan were highly stable with smaller sizes and dispersed well without aggregations in an aqueous environment. The drug loading and release can be further modified by modulating relative ratios of Fucoidan (Fu) to PLGA. The (FPN 3-DTX) nanoparticles with a 10:3 ratio of Fu:PLGA displayed uniform particle size with higher encapsulation efficiency than PLGA NPs and sustained drug release ability. The biocompatible fucoidan-PLGA nanoparticles displayed low cytotoxicity without drug loading after incubation with MDA-MB-231 triple-negative breast cancer cells. Despite lower cellular uptake than that of PLGA-DTX due to a higher degree of negative zeta potential and hydrophilicity, FPN 3-DTX effectively exerted better anticancer ability, so FPN 3-DTX can serve as a competent drug delivery system.

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Section: Discussionmentioning

confidence: 97%

Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

et al. 2020

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“…Different strategies, such as the use of nanotechnology, have emerged to tackle these problems. In general, nanoparticles-based drug delivery systems present important advantages, such as a long lifetime circulation, ability to improve the drug’s aqueous solubility as well the bioavailability, and the capacity to overcome physiological barriers [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Formulations of Curcumin Nanoparticles for Brain Diseases

et al. 2019

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Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms “curcumin” and “curcumin brain diseases”, which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.

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“…The obtained NPs were first characterized and compared to control empty NPs, both with and without PEI. All NPs produced showed hydrodynamic diameter ranging from 230 to 280 nm (Table 1), which is suitable for potential in vivo applications [34,35,36], and indicates that the presence of PEI and BSA does not affect the outcome of nanoprecipitation in terms of size. Conversely, PEI strongly affects the surface charge of NPs and leads to cationic NPs, as expected.…”

Section: Resultsmentioning

confidence: 99%

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles

2019

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Therapeutic proteins and enzymes are a group of interesting candidates for the treatment of numerous diseases, but they often require a carrier to avoid degradation and rapid clearance in vivo. To this end, organic nanoparticles (NPs) represent an excellent choice due to their biocompatibility, and cross-linked enzyme aggregates (CLEAs)-loaded poly (lactide-co-glycolide) (PLGA) NPs have recently attracted attention as versatile tools for targeted enzyme delivery. However, PLGA NPs are taken up by cells via endocytosis and are typically trafficked into lysosomes, while many therapeutic proteins and enzymes should reach the cellular cytosol to perform their activity. Here, we designed a CLEAs-based system implemented with a cationic endosomal escape agent (poly(ethylene imine), PEI) to extend the use of CLEA NPs also to cytosolic enzymes. We demonstrated that our system can deliver protein payloads at cytoplasm level by two different mechanisms: Endosomal escape and direct translocation. Finally, we applied this system to the cytoplasmic delivery of a therapeutically relevant enzyme (superoxide dismutase, SOD) in vitro.

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PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier

Cited by 74 publications

References 43 publications

Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

Formulations of Curcumin Nanoparticles for Brain Diseases

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles

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