Placebo-Controlled Study of the Effects of Atomoxetine on Bladder Control in Children With Nocturnal Enuresis

Sumner, Calvin R.; Schuh, Kory; Sutton, Virginia K.; Lipetz, Robert S.; Kelsey, Douglas K.

doi:10.1089/cap.2006.16.699

Cited by 56 publications

(26 citation statements)

References 23 publications

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“…Recent studies, including a double-blind randomized placebo-controlled trial, have noted that atomoxetine, a medication that is approved for the treatment of ADHD, has been found to decrease frequency of bedwetting among children with enuresis with or without ADHD 51,52. Interestingly, an earlier study found that the presence of ADHD predicted worse outcome for treatment of enuresis with alarm, DDAVP, or imipramine 53.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study

Shreeram

Kalaydjian

et al. 2009

Journal of the American Academy of Child & Adolescent Psych

146

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Objective-There are no published nationally representative prevalence estimates of enuresis among children in the United States using standardized diagnostic criteria. This study sets out to describe the prevalence, demographic correlates, comorbidities, and service patterns for enuresis in a representative sample of U.S. children.Method-The diagnosis of enuresis was derived from parent-reported data for "enuresis, nocturnal" collected using the computerized version of the Diagnostic Interview Schedule for Children (C-DISC 4.0) from a nationally representative sample of 8-to 11-year-old children (n = 1,136) who participated in the 2001-2004 National Health and Nutrition Examination Surveys.Results-The overall 12-month prevalence of enuresis was 4.45%. The prevalence in boys (6.21%) was significantly greater than that in girls (2.51%). Enuresis was more common at younger ages and among black youth. Attention-deficit/hyperactivity disorder (ADHD) was strongly associated with enuresis (odds ratio 2.88; 95% confidence interval 1.26-6.57). Only 36% of the enuretic children had received health services for enuresis.Conclusions-Enuresis is a common condition among children in the United States. Few families seek treatment for enuresis despite the potential for adverse effects on emotional health. Child health care professionals should routinely screen for enuresis and its effects on the emotional health of the child and the family. Assessment of ADHD should routinely include evaluation for enuresis and vice versa. Research on the explanations for the association between enuresis and ADHD is indicated. Keywords enuresis; prevalence; health care use; comorbidities; ADHD Enuresis is a distressing condition that involves repeated voiding of urine into clothes or bedclothes that persists beyond the normative age of maturation of urinary control. The prevalence estimates of enuresis are highly variable, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] with a range of 3.8% 19 to 24%. 5 The Correspondence to Srirangam Shreeram, M.D., Genetic Epidemiology, Branch, National Institute of Mental Health, 35 Convent Drive, 1A-202, MSC 3720, Bethesda, MD 20892-3720; s.shreeram@dc.gov. Disclosure: Dr. Shreeram has served on the speakers' bureau of Pfizer and serves as a consultant to Capital Clinical Research Associates, which conducts clinical trials for GlaxoSmithKline, Wyeth, Cephalon, Jazz Pharmaceuticals, Sanofi-Aventis, Takeda, Abbott, Forest, Novartis International AG, Pfizer, Bristol-Myers Squibb, Eli Lilly, Pherin Pharmaceuticals, Avera Pharmaceuticals, BrainCells, and AstraZeneca PLC. The other authors report no conflicts of interest.The National Health and Nutrition Examination Survey data are collected by the National Center for Health Statistics (NCHS). All analyses, interpretations, and conclusions expressed in this article are those of the authors and not the NCHS, which is responsible only for the initial data. 22 The DSM-III 23 and ICD-10 require a bed-wetting frequency of twice per month i...

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Section: Discussionmentioning

confidence: 99%

Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study

Shreeram

Kalaydjian

et al. 2009

Journal of the American Academy of Child & Adolescent Psych

146

View full text Add to dashboard Cite

show abstract

“…History of fecal incontinence was negative after toilet training. The patient's enuresis was unresponsive to multiple trials of pharmacologic agents, with evidence supporting their use for enuresis: Imipramine (Glazener et al 2003) up to 2 mg/kg for 6 weeks, desmopressin (Glazener and Evans 2002) in doses up to 40 lg as nasal spray as well as 0.4 mg orally plus a trial of atomoxetine (Sumner et al 2006). All had failed to produce even a single dry night.…”

Section: Case Reportmentioning

confidence: 99%

Corn Silk Tea and Enuresis

Kruesi

2016

Journal of Child and Adolescent Psychopharmacology

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“…Conditions whose standard therapy has been shown to be no better than placebo e e.g. primary nocturnal enuresis [32]. 3.…”

Section: The Logic Of Clinical Purposementioning

confidence: 99%

Placebo-controlled trials in pediatric urology: A cautionary view from an ethical perspective

Braga

Bägli

Lorenzo

2010

Journal of Pediatric Urology

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Placebo-Controlled Study of the Effects of Atomoxetine on Bladder Control in Children With Nocturnal Enuresis

Abstract: Compared with placebo, atomoxetine treatment was associated with a significant increase in dry nights in children with nocturnal enuresis.

Cited by 56 publications

References 23 publications

Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study

Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study

Corn Silk Tea and Enuresis

Placebo-controlled trials in pediatric urology: A cautionary view from an ethical perspective

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